CA2985547 SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

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Application Number 2985547

Application Date 13.05.2016

Publication Number 2985547

Publication Date 24.11.2016

Publication Kind A1

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Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED

Inventors KOTRABASAIAH UJJINAMATADA, RAVI
PANDIT, CHETAN

Priority Data 2448/CHE/2015 15.05.2015 IN

Title

(EN) SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

(FR) COMPOSES TETRAHYDROQUINOLINONE SUBSTITUES EN TANT QUE MODULATEURS DE ROR GAMMA

Abstract

(EN) The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as ROR? modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by ROR? receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

(FR) La présente invention concerne des composés de tétrahydroquinolinone substitués et des composés apparentés de formule (I), qui sont thérapeutiquement utiles en tant que modulateurs de récepteurs orphelins apparentés (ROR) au récepteur de l'acide rétinoïque, plus particulièrement en tant que modulateurs ROR?. Ces composés sont destinés au traitement et à la prévention de maladies et/ou d'un trouble, en particulier destinés à des maladies et/ou à un trouble induits par récepteur ROR?. L'invention concerne également la préparation des composés et des formulations pharmaceutiques comprenant la tétrahydroquinolinone substituée et/ou des composés apparentés de formule (I), ensemble avec un vecteur, diluant, ou excipient pharmaceutiquement acceptable correspondant.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36	Sulfur atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
04	directly linked by a ring-member-to-ring-member bond

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
487	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

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1. CA2985547 - SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19	Drugs for skeletal disorders
02	for joint disorders, e.g. arthritis, arthrosis

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines
472	Non-condensed isoquinolines, e.g. papaverine
4725	containing further heterocyclic rings