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1. (CA2934049) CRYSTALLINE FORMS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE

Office : Canada
Application Number: 2934049 Application Date:
Publication Number: 2934049 Publication Date: 02.07.2015
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS2014071310 ; Publication Number: Click to see the data
IPC:
C07K 5/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
12
Cyclic peptides
Applicants: GILEAD SCIENCES, INC.
Inventors:
Priority Data: 61/920,427 23.12.2013 US
Title: (EN) CRYSTALLINE FORMS OF A MACROCYCLIC HCV NS3 INHIBITING TRIPEPTIDE
(FR) FORMES CRISTALLINES D'UN COMPOSE ANTIVIRAL
Abstract: front page image
(EN) Crystalline forms of the anti-HCV compound (1R,5S,8S,9S,10R,22aR )-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6] dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state. Also provided are processes of manufacture and methods of using the crystalline forms.


Also published as:
UY0001035918EP3087086JP2017503016AU2014370124ES2708993WO/2015/100144