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1. (CA2906198) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS

Office : Canada
Application Number: 2906198 Application Date:
Publication Number: 2906198 Publication Date: 25.09.2014
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS2014029606 ; Publication Number: Click to see the data
IPC:
A61K 31/7088
C12N 15/113
A61P 35/00
A61P 35/04
C12N 15/11
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
CPC:
C12N 15/113
A61K 31/7088
A61K 31/7105
A61K 45/06
C12N 5/0693
C12N2310/113
C12N2320/30
C12N2320/31
C12N2501/65
C12N2501/999
C12N2510/00
Applicants: ANDES BIOTECHNOLOGIES S.A.
Inventors:
Priority Data: 61/785,269 14.03.2013 US
61/790,072 15.03.2013 US
61/937,438 07.02.2014 US
Title: (EN) ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER STEM CELLS
(FR) OLIGONUCLEOTIDES ANTISENS POUR LE TRAITEMENT DE CELLULES SOUCHES CANCEREUSES
Abstract: front page image
(EN) The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating and preventing metastasis or relapse of a cancer in an individual previously treated for cancer with a therapy. The invention also provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating a refractory cancer (e.g., a refractory HPV-associated cancer).


Also published as:
EP2970970CN105229150US20160138015BR112015022308ES2708650WO/2014/153209