CA2863018 A TABLET COMPRISING .ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTHYMIDINE AND 5-CHLORO-6-(2-IMINOPYRROLIDINE-1-YL)METHYL-2,4(1H,3H)-PYRIMIDINE DIONE HYDROCHLORIDE

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Application Number 2863018

Application Date

Publication Number 2863018

Publication Date 22.08.2013

Grant Number

Grant Date 07.01.2020

Publication Kind C

IPC

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Applicants TAIHO PHARMACEUTICAL CO., LTD.

Priority Data 2012-031144 15.02.2012 JP

Title

(EN) A TABLET COMPRISING .ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTHYMIDINE AND 5-CHLORO-6-(2-IMINOPYRROLIDINE-1-YL)METHYL-2,4(1H,3H)-PYRIMIDINE DIONE HYDROCHLORIDE

(FR) COMPRIME COMPRENANT DE L'.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTHYMIDINE ET DU CHLORHYDRATE DE 5-CHLORO-6-(2-IMINOPYRROLIDINE-1-YL)METHYL-2,4(1H,3H)-PYRIMIDINE DIONE

Abstract

(EN)

The present invention provides an FTD and
TPI-containing oral pharmaceutical composition which can be
orally administered and is stable even under high
humidity conditions.
An oral pharmaceutical composition comprising .alpha.,.alpha.,.alpha.-
trifluorothymidine and 5-chloro-6-(2-iminopyrrolidine-1-yl)
methyl-2,4(1H,3H)-pyrimidine dione hydrochloride as an
active ingredient; and being substantially free of an
additive comprising a metal salt.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof
7042	Compounds having saccharide radicals and heterocyclic rings
7052	having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706	containing six-membered rings with nitrogen as a ring hetero atom
7064	containing condensed or non-condensed pyrimidines
7068	having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
20	Pills, lozenges or tablets

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
20	Pills, lozenges or tablets
28	Dragees; Coated pills or tablets
30	Organic coatings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513	having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

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1. CA2863018 - A TABLET COMPRISING .ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTHYMIDINE AND 5-CHLORO-6-(2-IMINOPYRROLIDINE-1-YL)METHYL-2,4(1H,3H)-PYRIMIDINE DIONE HYDROCHLORIDE

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08	containing oxygen
10	Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08	containing oxygen
10	Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26	Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36	Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin