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1. BR122019023930 - anticorpo anti-cmet, seu uso e processo de preparação, ácido nucleico isolado que o codifica, composição que o compreende, vetor, bem como método de diagnóstico in vitro de doença

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Application Number 122019023930
Application Date 02.12.2009
Publication Number 122019023930
Publication Date 04.05.2021
Grant Number 122019023930
Grant Date 04.05.2021
Publication Kind B1
IPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
Applicants PIERRE FABRE MEDICAMENT
Inventors CÉDRIC BES
LILIANE GOETSCH
THIERRY WURCH
Agents DANNEMANN, SIEMSEN, BIGLER & IPANEMA MOREIRA
Priority Data PI0923231 02.12.2009 BR
61/184,502 05.06.2009 US
PCT/IB2008/055663 02.12.2008 WO
Title
(PT) anticorpo anti-cmet, seu uso e processo de preparação, ácido nucleico isolado que o codifica, composição que o compreende, vetor, bem como método de diagnóstico in vitro de doença
Abstract
(PT) a presente invenção refere-se a um anticorpo capaz de se ligar especificamente ao receptor c-met humano e/ou capaz de inibir especificamente a atividade de tirosina cinase do dito receptor, com uma atividade antagonística aperfeiçoada, o dito anticorpo compreendendo uma região de dobra modificada. uma composição compreen-dendo tal antagonista de anticorpo para c-met e seu uso como um medicamento para tratamento de câncer.
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