BRPI0517398 proteína isolada jak2, sequência nucleotídica, vetor de clonagem e/ou de expressão viral, sondas ou iniciadores, oligonucleotídeo, métodos ex vivo ou in vitro para determinar a presença ou a ausência da variante g1849t do gene jak2, anticorpo monoclonal, hibridoma, kit, sirna, processos in vitro permitindo determinar a inibição específica de jak2 v617f, de triagem, utilização de sirna, e, composição

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Application Number PI0517398

Application Date 26.10.2005

Publication Number PI0517398

Publication Date 02.03.2021

Grant Number PI0517398

Grant Date 25.05.2021

Publication Kind B8

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Applicants Assistance Publique - Hopitaux De Paris
Institut Gustave-Roussy
Institut National De La Sante Et De La Recherche Medicale (INSERM)
Universite Paris-Sud
Universite de Versailles-St Quentin en Yvelines

Inventors Chloé James
Jean-Pierre Le Couedic
Nicole Casadevall
Valérie Ugo
William Vainchenker

Agents Momsen, Leonardos & Cia

Priority Data 0411480 27.10.2004 FR

Title

(PT) proteína isolada jak2, sequência nucleotídica, vetor de clonagem e/ou de expressão viral, sondas ou iniciadores, oligonucleotídeo, métodos ex vivo ou in vitro para determinar a presença ou a ausência da variante g1849t do gene jak2, anticorpo monoclonal, hibridoma, kit, sirna, processos in vitro permitindo determinar a inibição específica de jak2 v617f, de triagem, utilização de sirna, e, composição

Abstract

(PT) proteína isolada, sequência nucleotídica, vetor, célula de mamífero, animal transgênico não humano, sondas ou iniciadores, métodos para determinar a presença ou a ausência da variante g1849t do gene jak2, para detectar a presença ou a ausência da variante jak2 v617f, anticorpo monoclonal, hibridoma, kit, sirna, processos permitindo determinar a inibição específica de jak2 v617f, de triagem, para a identificação de candidatos medicamentos, utilização de sirna, e, composição. a presente invenção refere-se à variante v617f da proteína tirosina cinase jak2, a referida variante sendo responsável pela poliglobulia de vaquez. a invenção refere-se igualmente a um método de diagnóstico em primeira intenção da eritrócitos e da trombocitoses permitindo as relacionar com as síndromes mieloproliferativas ou à detecção nas síndromes mieloproliferativas da variante jak2 v617f permitindo reclassificar as mesmas em um novo grupo nosológico e à identificação de inibidores específicos e de sirna.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients

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A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
574	for cancer
57407	Specifically defined cancers
57426	leukemia

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53	Immunoassay; Biospecific binding assay; Materials therefor
574	for cancer
57484	involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
57496	involving intracellular compounds

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333	Assays involving biological materials from specific organisms or of a specific nature
90	Enzymes; Proenzymes
91	Transferases (2.)
912	transferring phosphorus containing groups, e.g. kinases (2.7)
91205	Phosphotransferases in general
9121	with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
91215	with a definite EC number (2.7.1.-)

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500	Screening for compounds of potential therapeutic value
04	Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)