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218. (BRPI0710656) ÁCIDOS BIFENIL CARBOXÍLICOS SUBSTITUÍDOS E DERIVADOS DOS MESMOS

Application Number: PI0710656 Application Date: 20.04.2007
Publication Number: PI0710656 Publication Date: 01.07.2011
Publication Kind : A2
IPC:
C07C 59/68
C07C 229/42
A61K 31/192
A61K 31/196
A61P 25/28
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
40
Unsaturated compounds
58
containing ether groups, groups, groups, or groups
64
containing six-membered aromatic rings
66
the non-carboxylic part of the ether containing six-membered aromatic rings
68
the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
229
Compounds containing amino and carboxyl groups bound to the same carbon skeleton
40
having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
42
with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants: Cellzome Limited
Ortho-Mcneil-Janssen Pharmaceuticals, Inc.
Inventors: Adeline Morel
Alison Jones
Andrew Cansfield
Chih Yung Ho
Cyrille Boussard
Francis Wilson
Jeremy Major
Agents: Dannemann ,Siemsen, Bigler & Ipanema Moreira
Priority Data: 06112938 21.04.2006 EP
Title: (PT) ÁCIDOS BIFENIL CARBOXÍLICOS SUBSTITUÍDOS E DERIVADOS DOS MESMOS
Abstract:
(PT) ÁCIDOS BIFENIL CARBOXÍLICOS SUBSTITUIDOS E DERIVADOS DOS MESMOS. A presente invenção refere-se a compostos tendo a fórmula geral (I) com as definições de X, Y, R^ 1^,R^ 2^, R^ 3^, R^ 4^, R^ 9^, e R^ 10^ dadas abaixo, e/ou um sal ou áster dos mesmos. Além disso a invenção refere-se ao uso dos referidos compostos para o tratamento do mal de Alzheimer e uso dos mesmos para a modulação da atividade da -secretase.