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1. BR112018005936 - inibidores de isoindolinona da interação de mdm2-p53 que têm atividade anticâncer

Office
Brazil
Application Number 112018005936
Application Date 29.09.2016
Publication Number 112018005936
Publication Date 16.10.2018
Publication Kind A2
IPC
C07B 59/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds
C07D 401/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
C07D 401/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
C07D 403/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
C07D 405/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
C07D 407/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
CPC
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
C07B 2200/05
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
05Isotopically modified compounds, e.g. labelled
C07B 59/002
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
002Heterocyclic compounds
C07D 403/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants ASTEX THERAPEUTICS LIMITED
CANCER RESEARCH TECHNOLOGY LIMITED
Inventors ARWEL LEWIS
BENJAMIN DAVID CONS
BENJAMIN PAUL WHITTAKER
BERNARD THOMAS GOLDING
CELINE FLORENCE CANO
CHRISTOPHER NORBERT JOHNSON
DALE ROBERT MITCHELL
DAVID CHARLES REES
DAVID WYN WATSON
DUNCAN CHARLES MILLER
EMILIANO TAMANINI
GIANNI CHESSARI
IAN ROBERT HARDCASTLE
ILDIKO MARIA BUCK
JAMES DANIEL OSBORNE
JEFFREY DAVID ST. DENIS
JOANNE PEACH
KIM LOUISE HIRST
MARTIN EDWARD MÄNTYLÄ NOBLE
RHIAN SARA HOLVEY
ROGER JOHN GRIFFIN (FALECIDO)
STEVEN HOWARD
Agents DANNEMANN, SIEMSEN, BIGLER & IPANEMA MOREIRA
Priority Data 1517216.6 29.09.2015 GB
Title
(PT) inibidores de isoindolinona da interação de mdm2-p53 que têm atividade anticâncer
Abstract
(PT) a invenção fornece um composto da fórmula (i): (i) ou tautômero ou um solvato ou um sal farmaceuticamente aceitável do mesmo, em que os diversos substituintes são como definidos nas reivindicações. fornece-se também composições farmacêuticas que contêm os compostos da fórmula (i), processos para fazer os compostos e os usos médicos dos compostos.
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