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1. BR112018003486 - ?molécula, rna, métodos para obter rna, métodos para obter um peptídeo e usos do rna?

Office
Brazil
Application Number 112018003486
Application Date 05.10.2016
Publication Number 112018003486
Publication Date 25.09.2018
Publication Kind A2
IPC
C12N 15/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants BIONTECH RNA PHARMACEUTICALS GMBH
TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ GGMBH
Inventors ALEXANDRA ORLANDINI VON NIESSEN
ANDREAS KUHN
BRITTA VALLAZZA
MARCO ALEXANDER POLEGANOV
STEPHANIE FESSER
TIM BEISSERT
UGUR SAHIN
Agents ANA PAULA SANTOS CELIDONIO
Priority Data PCT/EP2015/073180 07.10.2015 EP
Title
(PT) ?molécula, rna, métodos para obter rna, métodos para obter um peptídeo e usos do rna?
Abstract
(PT)
a presente invenção refere-se à estabilização de rna, em particular mrna, e um aumento na tradução de mrna. a presente invenção particularmente refere-se a uma modificação de rna, em particular rna transcrito in vitro, resultando em estabilidade de transcrito aumentada e/ou eficiência de tradução. de acordo com a invenção, demonstrou-se que determinadas sequências na região não traduzida 3? (utr) de uma molécula de rna melhora a estabilidade e eficiência de tradução.