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11. (BR112014000713) derivados de indol substituído como moduladores de gama secretase

Application Number: 112014000713 Application Date: 12.07.2012
Publication Number: 112014000713 Publication Date: 10.01.2017
Publication Kind : A2
Prior PCT appl.: Application Number:PCTEP2012063667 ; Publication Number:WO2013010904 Click to see the data
IPC:
C 07
C 07
A 61
A 61
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Applicants: CELLZOME LIMITED
Janssen Pharmaceuticals, Inc.
Inventors: ADRIANA INGRID VELTER
DIDIER JEAN-CLAUDE BERTHELOT
FRANÇOIS PAUL BISCHOFF
GARRETT BERLOND MINNE
HENRICUS JACOBUS MARIA GIJSEN
SERGE MARIA ALOYSIUS PIETERS
Agents: DANNEMANN, SIEMSEN, BIGLER & IPANEMA MOREIRA
Priority Data: 11 174120.3 15.07.2011 EP
Title: (PT) derivados de indol substituído como moduladores de gama secretase
Abstract:
(PT) abstractnovel substituted indole derivatives as gamma secretase modulators____________________________________________the present invention is concerned with novel substituted indole derivatives of formula (i)wherein r1, r2, r3, a1, a2, a3, y and x have the meaning defined in the claims. the compounds according to the present invention are useful as gamma secretase modulators. the invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.129*******************************************************tradução do resumoresumopatente de invenção: "derivados de indol substituído como moduladores de gama secretase". a presente invenção refere-se a novos derivados de indol substituído de fórmula (i)em que r1, r2, r3, a1, a2, a3, y e x têm o significado definido nas reivindicações. os compostos de acordo com a presente invenção são úteis como moduladores de gama secretase. a invenção também se refere a processos para a preparação desses compostos novos, a composições farmacêuticas compreendendo os referidos compostos como ingrediente ativo, bem como à utilização dos referidos compostos como medicamento.