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1. (BG102313) METHOD FOR THE PREPARATION OF MULTILAYER SOLID MEDICAMENTOUS FORMS FOR ORAL OR RECTAL ADMINISTRATION

Office : Bulgaria
Application Number: 10231398 Application Date: 10.03.1998
Publication Number: 102313 Publication Date: 30.10.1998
Publication Kind : A
IPC:
A61J 3/10
A61K 9/20
A61K 9/24
A61K 9/28
A61K 31/07
A61K 31/167
A61K 31/192
A61K 31/277
A61K 31/355
A61K 31/375
A61K 31/401
A61K 31/4422
A61K 31/52
A61K 31/522
A61K 31/60
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
J
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3
Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
10
into the form of compressed tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
24
Layered or laminated unitary dosage forms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
07
Retinol compounds, e.g. vitamin A
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
355
Tocopherols, e.g. vitamin E
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
375
Ascorbic acid, i.e. vitamin C; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401
Proline; Derivatives thereof, e.g. captopril
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4422
1,4-Dihydropyridines, e.g. nifedipine, nicardipine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
522
having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
60
Salicylic acid; Derivatives thereof
CPC:
A61J 3/10
A61J 2200/20
A61K 9/209
A61K 9/2095
A61K 9/2893
A61K 31/07
A61K 31/167
A61K 31/192
A61K 31/277
A61K 31/355
A61K 31/375
A61K 31/401
A61K 31/4422
A61K 31/52
A61K 31/522
A61K 31/616
B30B 11/14
B30B 11/16
B30B 11/18
B30B 11/34
B30B 15/308
Applicants: BASF AG
Inventors: BREITENBACH JOERG
HAERTL AXEL P
HOFMANN JUERGEN
ROSENBERG JOERG
SCHIESSL MICHAEL
ZETTLER HANS D
Priority Data: 19539361 23.10.1995 DE
9604601 23.10.1996 EP
Title: (BG) МЕТОД ЗА ПОЛУЧАВАНЕ НА МНОГОСЛОЙНИ ТВЪРДИ ЛЕКАРСТВЕНИ ФОРМИ ЗА ОРАЛНО ИЛИ РЕКТАЛНО ПРИЛОЖЕНИЕ
(EN) METHOD FOR THE PREPARATION OF MULTILAYER SOLID MEDICAMENTOUS FORMS FOR ORAL OR RECTAL ADMINISTRATION
Abstract:
(BG) Изобретението се отнася до метод, при който едновременно се екструдират най-малко две маси, всяка от които съдържа термопластично, фармакологично приемливо и разтворимо във физиологична среда или набъбващо полимерно свързващо средство, като поне едната от тях включва и фармацевтично активно вещество. Съекструдираният многослоен материал се формовадо желаната лекарствена форма. 1
(EN) The invention relates to a method where at least two massesare simultaneously extruded each containing a thermoplastic,pharmacologically acceptable and physiological medium-soluble orexpanding polymer binder, at least one of them also including apharmaceutically active substance. The co-extruded multilayermaterial is moulded to the desired medicamentous form.10 claims
Also published as:
CZPV1998-1242NO19981793ES2175139EP0857062US6120802JPH11513697
CN1200033CA2232356PT857062KR1019990066978DK0857062AU1996074912
MYPI 96004363WO/1997/015293