(EN) Medicinal compositions containing: (1) a pharmacologically active substance; (2) a drug sorbefacient; and (3) a taurine compound or a polyamine. A taurine compound has an effect of lessening or preventing injuries on the intestinal mucosa. By adding the taurine compound to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, injuries on the intestinal mucosa due to the drug sorbefacient can be lessened or prevented. A polyamine has an effect of improving the absorbability of a pharmacologically active substance. By adding the polyamine to medicinal compositions containing a pharmacologically active substance and a drug sorbefacient, therefore, the dose of the drug sorbefacient can be decreased and thus injuries on intestinal mucosa can be lessened or prevented.