(EN) The present invention provides a compound of formula I
I
or pharmaceutical acceptable salts thereof wherein R1 is C4 12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-het, R2 is substituted and unsubstituted
C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-C3_8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH 2)h-heterocyclic ring,
substituted and unsubstituted -(CH 2 )-X-R 4 (X is -NR7 2 NR8 and-(CH2 )CHR 5 R6
The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
