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1. (AU2015261812) 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are JAK inhibitors
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Claims:
1. A compound selected from the group consisting of:
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-(cyclopropylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-5-amino pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-6-methyl pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl 1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]-3 [5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine 3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-ethyl-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-isopropyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5 yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-(2-phenylethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-(3-hydroxypropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
3-hydroxypropyl (3aR,6aS)-2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 (pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrole-5-carboxylate,
N-[1-[2-[(3aR,6aR)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
benzyl 4-[[(3aR,6aS)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 (pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]piperidine-1-carboxylate,
N-[1-[2-[(3aR,6aS)-2-[3-(2-oxopyrrolidin-1-yl)propyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-morpholinopropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,7aS)-2,3,3a,4,5,6,7,7a-octahydropyrrolo[3,2-c]pyridin-1-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,7aR)-1,2,3,3a,4,6,7,7a-octahydropyrrolo[3,4-c]pyridin-5-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-[(1-acetyl-4-piperidyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 4-[[(3aS,6aR)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 (pyrazolo[1,5-a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-2-yl]methyl]piperidine-1-carboxylate,
N-[1-[2-[(3aS,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,7aS)-2-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin 5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-(tetrahydropyran-4-ylmethyl)-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-(3-methylsulfonylpropyl)-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-isobutyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5 yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(1-methyl-3,3a,4,6,7,7a hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(5-methyl-3,3a,4,6,7,7a hexahydro-1H-pyrrolo[3,4-c]pyridin-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-(2-methylsulfonylethyl)-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[3-(2-oxooxazolidin-3-yl)propyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[(4,4-difluorocyclohexyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[(1-methylsulfonyl-4-piperidyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[[1-(tetrahydropyran-4-carbonyl)-4-piperidyl]methyl] 1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-[[1-(dimethylcarbamoyl)-4-piperidyl]methyl] 1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,4S,6R,6aR)-6-(hydroxymethyl)-2-methyl-4-phenyl-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(3-methoxypropyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-[(3-methyloxetan-3-yl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,6aS)-2-(cyclobutylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,7aS)-1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,7aR)-1-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aS)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aR)-2-methyl-3a-phenyl-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-[(1-hydroxycyclohexyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aS,6aR)-2-[(1-cyanocyclohexyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin 2-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-(3-hydroxy-3-methyl-butyl)-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
3-[(3aR,6aS)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-2-yl]propyl morpholine-4-carboxylate,
N-[1-[2-[(3aR,6aS)-2-(cyclohexylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-1H-pyrrolo[3,4-c]pyridin 2-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-[3-(2-oxoindolin-1-yl)propyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
3-[(3aS,6aR)-5-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-2-yl]propyl cyclobutanecarboxylate,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(1-methyl 3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin-5-yl)-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-(cyclopropylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-2 amino-pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-[(4,4-difluorocyclohexyl)methyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[(3aR,6aS)-2-(2,2,2-trifluoroethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-[2-[(4-chlorophenyl)methoxy]ethyl]-1,3,3a,4,6,6a hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(3aR,7aR)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,7aS)-5-methyl-3,3a,4,6,7,7a-hexahydro-2H-pyrrolo[3,2-c]pyridin 1-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 cyanoethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)azetidin-1 yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3-(dimethylamino)pyrrolidin 1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-(4-amino-1-piperidyl)-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 methoxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-pyrrolidin-1-yl-1 piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(dimethylamino)methyl]-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3 [(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3 [(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(dimethylamino)ethoxy] 1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(dimethylamino)methyl]-4 hydroxy-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(ethylamino)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3R)-3 hydroxypyrrolidin-1-yl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3S)-3 hydroxypyrrolidin-1-yl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2R)-2 [(dimethylamino)methyl]pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2S)-2 [(dimethylamino)methyl]pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(dimethylamino)methyl]-4 phenyl-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-[(2S)-2-(aminomethyl)pyrrolidin-1-yl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3 [(dimethylamino)methyl]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(methylamino)-1-piperidyl] 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(cyclobutylamino)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2 phenylethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-(2 pyridyl)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-cyanoethylamino)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[[4-(dimethylamino)-4-oxo butyl]-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(2 phenylethylamino)-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-hydroxyphenyl)ethyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4 hydroxyphenyl)ethylamino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4 chlorophenyl)ethylamino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[2-[4 (trifluoromethyl)phenyl]ethylamino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-chlorophenyl)ethyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-methoxyphenyl)ethyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[(3-methyloxetan-3 yl)methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-[4 (trifluoromethyl)phenyl]ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[4-[benzyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2,2,2 trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2 phenoxyethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 cyclohexylethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2,2-difluoro-2-phenyl ethyl)-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[2-phenylethyl(2,2,2 trifluoroethyl)amino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[2-(4-bromophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl] 3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[2-(2-bromophenoxy)ethyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl] 3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(2-chlorophenoxy)ethyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(4-chlorophenoxy)ethyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[butyl-[2-(4-methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl] 3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[allyl-[2-(4-methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl] 3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[2-(4 methylphenoxy)ethyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4,4-difluoro-1 piperidyl)methyl]-4-phenyl-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[4-[1,3-benzodioxol-2-ylmethyl(methyl)amino]-1-piperidyl]-2-oxo ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[(3 phenoxyphenyl)methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(1 cyanocyclohexyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[4-[butyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5 chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[benzyl(2,2,2-trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5 chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3-methyloxetan-3 yl)methyl-(3,3,3-trifluoropropyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[4-[benzyl(3,3,3-trifluoropropyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5 chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[(4-bromophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3 [5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[(4-tert-butylphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(3,4 dichlorophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[4-[(3-bromophenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3 [5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(3 phenylpropyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4 isopropoxyphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4-chlorophenyl)methyl methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[(4-butoxyphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]-3 [5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl-[[3 (trifluoromethyl)phenyl]methyl]amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2,4 dimethylphenyl)methyl-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2 naphthylmethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[1-[2-[4-[(3-bromo-4-fluoro-phenyl)methyl-methyl-amino]-1-piperidyl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-[(2,2,2-trifluoro-1 phenyl-ethyl)amino]-1-piperidyl]ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[(1-benzyl-2,2,2-trifluoro-ethyl)-methyl-amino]-1-piperidyl]-2-oxo ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2,2 difluoropropyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(5-chloroisoindolin-2-yl)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3 (dimethylamino)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 (dimethylamino)ethoxy]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[3 (dimethylamino)azetidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino) 1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 hydroxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 methoxyethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[1-(3-acetamidopropyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-oxo-4-(1 piperidyl)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[1-(1-acetyl-4-piperidyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[1-[1-(3-benzamidopropyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2-oxopyrrolidin-1 yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-morpholino-4-oxo butyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(dimethylamino) 4-oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(methylamino)-4 oxo-butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[1-(3-acetamidopropyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[1-[1-[3-[benzoyl(methyl)amino]propyl]-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-oxo-4-(tetrahydropyran-4 ylamino)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(oxetan-3-ylamino)-4-oxo butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(3-methyl-2-oxo imidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2-oxopyrrolidin-1 yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(ethylamino)-4-oxo-butyl] 4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[2-(methylamino)-2-oxo ethyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-morpholinopropyl)-4 piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-thiomorpholinopropyl)-4 piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(methylamino)-3-oxo propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(1,1-dioxo-1,4-thiazinan-4 yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[1-[1-(4-amino-4-oxo-butyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(2 oxoimidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[3-(3-methyl-2-oxo imidazolidin-1-yl)propyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[1-[1-(3-amino-3-oxo-propyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-[1-[3-(3-benzyl-2-oxo-imidazolidin-1-yl)propyl]-4-piperidyl]-3 [5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[1-[1-[4-(benzylamino)-4-oxo-butyl]-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(methylamino)-4-oxo butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-morpholino-4-oxo-butyl)-4 piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[1-(4-amino-4-oxo-butyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[1-(azepan-4-yl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-methylazepan-4 yl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[1-[(1-acetyl-4-piperidyl)methyl]-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]-2-amino-pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-isobutyl-4 piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl 4-[4-[4-[(2-aminopyrazolo[1,5-a]pyrimidine-3-carbonyl)amino]-3-[5 chloro-2-(difluoromethoxy)phenyl]pyrazol-1-yl]-1-piperidyl]butanoate,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3-hydroxypropyl)-4 piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(3 methylsulfonylpropyl)-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[1-(1-benzyl-4-piperidyl)-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-(4-phenylbutyl)-4 piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[1-[1-(2-benzyloxyethyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[1-[4-(2 phenylethoxy)butyl]-4-piperidyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S)-1 methylpyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R)-1 methylpyrrolidin-3-yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(1-methyl-4 piperidyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R)-pyrrolidin-3 yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S)-pyrrolidin-3 yl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-[(1 cyanocyclohexyl)methyl-methyl-amino]piperidine-1-carbonyl]phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(dimethylamino)-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[2-cyanoethyl(methyl)amino] 1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(dimethylamino)methyl]-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[2-(dimethylamino)ethyl]-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl(2-phenylethyl)amino] 1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[2-[4-[(4-amino-4-oxo-butyl)-methyl-amino]-1-piperidyl]-4-[5-chloro-2 (difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(3-fluoroazetidin-1-yl)-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(1-piperidyl)azetidin-1 yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(3,3-difluoroazetidin-1-yl)-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-(dimethylamino)piperidine 1-carbonyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl(2,2,2 trifluoroethyl)amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[4-[butyl(methyl)amino]-1-piperidyl]-4-[5-chloro-2 (difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl-[(3-methyloxetan-3 yl)methyl]amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[4-[benzyl(methyl)amino]-1-piperidyl]-4-[5-chloro-2 (difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-[methyl(2,2,2 trifluoroethyl)amino]piperidine-1-carbonyl]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(1-cyanocyclohexyl)methyl methyl-amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-[(1 cyanocyclohexyl)methyl-methyl-amino]piperidine-1-carbonyl]-1-piperidyl]thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-methylpiperazin-1-yl)thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(2-phenylethyl)piperazin-1 yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(cyclopropylmethyl)piperazin 1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(2,2,2-trifluoroethyl)piperazin 1-yl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(dimethylamino)prop-1 ynyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[2-[3-[butyl(methyl)amino]prop-1-ynyl]-4-[5-chloro-2 (difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7 diazaspiro[3.4]octan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7 diazaspiro[4.4]nonan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(9-methyl-1-oxa-4,9 diazaspiro[5.5]undecan-4-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(6-methyl-2,6 diazaspiro[3.3]heptan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(9-methyl-1-oxa-4,9 diazaspiro[5.5]undecan-4-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7 diazaspiro[3.5]nonan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,7-diazaspiro[3.5]nonan-2 yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,7 diazaspiro[3.5]nonan-7-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,6-diazaspiro[3.4]octan-6-yl) 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,7-diazaspiro[3.4]octan-2-yl) 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,6 diazaspiro[3.4]octan-6-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(8-methyl-2,8 diazaspiro[4.5]decan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,8-diazaspiro[4.5]decan-8 yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-methyl-2,8 diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2-isobutyl-2,8 diazaspiro[4.5]decan-8-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
benzyl 4-[[8-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]acetyl]-2,8-diazaspiro[4.5]decan-2 yl]methyl]piperidine-1-carboxylate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methylpiperazin-1-yl)-2 oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethyl)piperazin 1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methoxyethyl)piperazin 1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(3-hydroxypropyl)piperazin 1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2-(2 hydroxyethoxy)ethyl]piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2 methylsulfonylethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-ethylpiperazin-1-yl)-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3-(hydroxymethyl)-4 methyl-piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3-(hydroxymethyl)-4 methyl-piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-phenylpiperazin-1 yl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(4-cyanophenyl)piperazin-1 yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(4 cyanophenyl)methyl]piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methyl-1,4-diazepan-1-yl) 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethyl)-1,4 diazepan-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl)-2-oxo-ethyl]-3-[5 chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1S,5R)-8-methyl-3,8 diazabicyclo[3.2.1]octan-3-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methylpiperazin-1 yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2 hydroxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2 methoxyethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methyl-1,4 diazepan-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-ethylpiperazin-1 yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4 (cyclopropylmethyl)piperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-piperazin-1-yl ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1S,4S)-5-methyl 2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R,5S)-3,5 dimethylpiperazin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1R,4R)-5-methyl 2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-(dimethylamino)piperidine 1-carbonyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-pyridyl)thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4 [(dimethylamino)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(3-fluoroazetidin-1 yl)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[(3,3-difluoroazetidin-1 yl)methyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(4-methylpiperazin-1 yl)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(4-methylpiperazine-1 carbonyl)phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[[4-(dimethylamino)-1 piperidyl]methyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[[methyl(2 phenylethyl)amino]methyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[2-[[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5 yl]methyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(1-piperidylmethyl)thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5 carbonyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(dimethylamino)piperidine-1 carbonyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(hydroxymethyl) 1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2S)-2-(1,2 dihydroxyethyl)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2S)-2 (hydroxymethyl)pyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3-hydroxy-3-methyl pyrrolidin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, 2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3S)-3 hydroxypyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(3R)-3 hydroxypyrrolidin-1-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-hydroxy-4 (hydroxymethyl)-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[2 (hydroxymethyl)morpholin-4-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(hydroxymethyl)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-hydroxyethoxy)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-hydroxy-4-(4-pyridyl)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[2-(hydroxymethyl)morpholin 4-yl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-1-piperidyl)-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[1-[2-(4-benzyl-4-hydroxy-1-piperidyl)-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-methyl-1 piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-cyano-4-phenyl-1 piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,3 difluoropyrrolidin-1-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-cyano-4-phenyl-1 piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,6-dihydro-2H-pyridin-1-yl) 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4-phenoxy-1 piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-phenyl 1-piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,3-difluoropyrrolidin-1-yl)-2 oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-morpholino-2-oxo ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-4-phenyl-1 piperidyl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-morpholino-2-oxo ethyl)pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[[1 (hydroxymethyl)cyclopropyl]methylamino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(1 hydroxycyclopentyl)methyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[[1 (hydroxymethyl)cyclopropyl]-methyl-amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2 methoxyethylamino)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[1-(2-aminoethyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(iS,3R)-3 (methylamino)cyclohexyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[1-(3-aminocyclobutyl)-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[3 (methylamino)cyclobutyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[ethyl-[(2-methyl-4 pyridyl)methyl]amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(2-chloro-4-pyridyl)methyl ethyl-amino]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[ethyl(3-pyridylmethyl)amino] 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-(dimethylamino)piperidine 1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-[methyl(2,2,2 trifluoroethyl)amino]piperidine-1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-(3-amino-3-imino-propyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol 4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-(4-amino-4-imino-butyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol 4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl 2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]ethylamino]acetate,
cyclopentyl 2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]ethylamino]acetate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(1 piperidyl)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl (2S)-2-amino-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]butanoate,
2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo [1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetic acid,
2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]ethyl)piperidin-4-yl]amino]acetic acid,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[2 (methylsulfanyl)ethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-(benzylamino)ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2-[(pyridin-2 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-4 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(1 phenylethyl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methylpropy)piperazin 1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(3-methyloxetan-3 yl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4- propylpiperazin-1 yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro- 2-(difluoromethoxy)phenyl]-1-(2-[4-[2-(morpholin-4-yl)ethyl] piperazin-1-yl]- 2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate,
N-[3-[5-chloro-2- (difluoromethoxy)pyridin-3-yl]-1-[(5-oxooxolan-2-yl)methyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4 [(dimethylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-(2-[[(2 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-(2-[[(3 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(4 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
methyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-[2-[4-(5-hydroxy-2-oxopiperidin 1-yl)piperidin-1-yl]-2-oxoethyl] -1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
methyl 3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate,
3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate,
methyll-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4 carboxylate,
ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4 carboxylate,
methyl 1-[2-[4-(2-[3-[5-chloro-2- (difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine 4-carboxylate,
2-(morpholin-4-yl)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4- [pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine 4-carboxylate,
2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo [1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 2-(morpholin-4-yl)ethyll-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo [1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
piperidin-4-ylmethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylic acid,
1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylic acid,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-[2-(4-[methyl[(5-oxooxolan-2 yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
methyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo [1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-([[4 (methylsulfanyl)phenyl]methyl]amino)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(2-oxooxan-4 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4 ylmethyl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(4-methylpiperazin-1 yl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(4-methylpiperazin-1 yl)methyl]piperidin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxo-2,5 dihydrofuran-3-yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-[methyl[(5-oxo-2,5 dihydrofuran-3-yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoic acid,
tert-butyl (3R,4R)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3S,4S)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3R,4R)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate,
tert-butyl (3S,4S)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1- [(3R,4R)-3-hydroxypiperidin-4 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-[(3S, 4S)-3-hydroxypiperidin-4 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R,4R)-4-hydroxypiperidin-3 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S, 4S)-4-hydroxypiperidin-3 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetate, 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetic,
ethyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate,
2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetic acid,
ethyl 2-(4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]piperidin-1-yl)acetate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1,3-oxazol-2 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-3 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(methylamino)propyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(dimethylamino)propyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(ethylamino)propyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2 (methylsulfanyl)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(propan-2 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4 (cyclopropylmethyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,4-dimethylpiperazin-1-yl)-2 oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,4-dimethylpiperazin-1-yl)-2 oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(2,2,4 trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3
carboxamide, 
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(3,3,4 trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2 (dimethylamino)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(1,3-oxazol-2 ylmethyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(5-oxooxolan-2 yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxooxolan-2 yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4 [(methylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1R)-1 phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1S)-1 phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)amino]acetate,
methyl (2S)-2-amino-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]butanoate,
(1-methylpiperidin-4-yl)methyl1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, (1-methylpiperidin-4-yl)methyl1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[methyl[(5-oxooxolan-2 yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(5-oxooxolan-3 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4-yl)piperidin 1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(morpholin-4-yl)but-2-en 1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(4-methylpiperazin-1 yl)but-2-en-1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-(methylthio)ethyl 2-(2-(3-(5-chloro-2-(difluoromethoxy)phenyl)-4 (pyrazolo[1,5-a]pyrimidine-3-carboxamido)-1H-pyrazol-1-yl)ethylamino)acetate, ethyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methylpiperazine-1 carbonyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((S)-tetrahydrofuran-3 ylamino)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-(dimethylamino)-2 oxoethyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-(dimethylamino)-2 oxoethylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((R)-tetrahydrofuran-3 ylamino)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-hydroxy-3-morpholinopropyl) 1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-(dimethylamino)-2 hydroxypropyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-hydroxy-3-(piperidin-1 yl)propyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyanoethyl)piperazin-1 yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(3-oxopiperazin-1 yl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(piperazine-1 carbonyl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanopyrrolidin-1 yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-methyl-4 morpholinopiperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-(dimethylamino)-2-oxopropyl) 1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(3-morpholino-2-oxopropyl)-1H pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2 cyanopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((S)-3-cyano-1,4'-bipiperidin '-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methylpiperidin-4 ylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methyl-3-oxopiperazin-1 yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(2-oxopiperazin-1-yl)ethyl) 1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-3-(piperidin-1-yl)propyl) 1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2 cyanopropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2 cyanoethyl)(methyl)amino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2 cyanoethylamino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(1-(2-(4-aminocyclohexylidene)ethyl)-3-(5-chloro-2 (difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((S)-2 (dimethylcarbamoyl)pyrrolidin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-2 (dimethylcarbamoyl)pyrrolidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((S)-2 (methylcarbamoyl)pyrrolidin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-2 (methylcarbamoyl)pyrrolidin-1-yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((4-(2-(dimethylamino)-2 oxoethyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((1-(2-(dimethylamino)-2 oxoethyl)piperidin-4-yl)methyl)piperazin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(tetrahydro-2H pyran-4-yl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methyl hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((1 cyanocyclopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((R) tetrahydrofuran-3-yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(1-(2-(4-(((1,3-dioxolan-2-yl)methyl)(methyl)amino)piperidin-1-yl)-2 oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4 thiomorpholinopiperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1 (cyanomethyl)cyclopropyl)methyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(1 cyanocyclopropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(tetrahydrofuran-3 yl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((2-methyl-1,3 dioxolan-2-yl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(octahydropyrrolo[3,4 b]pyridin-6-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methyl octahydropyrrolo[3,4-b]pyridin-6-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(1-(2-(4-(1,4-oxazepan-4-yl)piperidin-1-yl)-2-oxoethyl)-3-(5-chloro-2 (difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl((S)-tetrahydrofuran 3-yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4 thiomorpholinopiperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((3aS,6aS) hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(2-oxopiperazin-1 yl)piperidin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanoazetidin-1 yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(1-(2-(4-((1S,4S)-5-oxa-2-aza-bicyclo[2.2.1]heptan-2-yl)piperidin-1-yl)-2 oxoethyl)-3-(5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(4-methyl-2-oxopiperazin-1 yl)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((R)-3 methylmorpholino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(1-(2-(4-(6-oxa-3-aza-bicyclo[3.1.1]heptan-3-yl)piperidin-1-yl)-2-oxoethyl)-3 (5-chloro-2-(difluoromethoxy)phenyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((S)-3 methylmorpholino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(piperidin-4-yl)-1H-1,2,3 triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-morpholino-2 oxoethoxy)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-methylpiperidin-4-yl)-1H 1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-(tetrahydrofuran-3 yl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3 cyanopropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-(tetrahydro-2H-pyran-4 yl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-((tetrahydro-2H pyran-4-yl)methyl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(methyl(oxetan-3 yl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-oxo-2-(4-(2 thiomorpholinoethyl)piperazin-1-yl)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(3-cyanopropyl)piperazin-1 yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-cyano-1,4'-bipiperidin-' yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2,2 difluoropropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((3 cyanopropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyano-2 methylpropyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyano-2 methylpropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1 cyanocyclopropyl)methyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, and
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1 cyanocyclopropyl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
or  a  salt  thereof. 
2.              The compound according to claim 1 selected from the following group: N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-ethyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-2 oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-(cyclopropylmethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-5-amino pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]-6-methyl pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 cyanoethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[1-(3-acetamidopropyl)-4-piperidyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-(dimethylamino)-1 piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[2-cyanoethyl(methyl)amino] 1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-methylpiperazin-1-yl)thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(dimethylamino)prop-1 ynyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(7-methyl-2,7 diazaspiro[3.4]octan-2-yl)-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-methylpiperazin-1-yl)-2 oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-ethylpiperazin-1-yl)-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[4-(dimethylamino)piperidine 1-carbonyl]phenyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[[4-(dimethylamino)-1 piperidyl]methyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[2-[(3aR,6aS)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5 carbonyl]-4-[5-chloro-2-(difluoromethoxy)phenyl]thiazol-5-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
2-amino-N-[1-(3-aminocyclobutyl)-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[4-[4-(dimethylamino)piperidine 1-carbonyl]phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-(3-amino-3-imino-propyl)-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol 4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl 2-[2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-(pyrazolo[1,5 a]pyrimidine-3-carbonylamino)pyrazol-1-yl]ethylamino]acetate,
2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo [1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]aceticacid,
2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]ethyl)piperidin-4-yl]amino]aceticacid,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[2 (methylsulfanyl)ethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-(benzylamino)ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-2 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-4 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(1 phenylethyl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(2-methylpropyl)piperazin 1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(3-methyloxetan-3 yl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(4- propylpiperazin-1 yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-(4-benzylpiperazin-1-yl)-2-oxoethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro- 2-(difluoromethoxy)phenyl]-1-(2-[4-[2-(morpholin-4-yl)ethyl] piperazin-1-yl]- 2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate,
N-[3-[5-chloro-2- (difluoromethoxy)pyridin-3-yl]-1-[(5-oxooxolan-2-yl)methyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-[2-oxo-2-(piperazin-1-yl)ethyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4 [(dimethylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2- (difluoromethoxy)phenyl]-1-(2-[[(2 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-(2-[[(3 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(4 hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
methyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(5-hydroxy-2-oxopiperidin 1-yl)piperidin-1-yl]-2-oxoethyl] -1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
methyl 3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate,
3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoate,
methyll-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4 carboxylate,
ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]piperidine-4 carboxylate,
methyl 1-[2-[4-(2-[3-[5-chloro-2- (difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine 4-carboxylate,
2-(morpholin-4-yl)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, ethyl 1-[2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4- [pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]ethyl]-4-methylpiperidine 4-carboxylate,
2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 2-(morpholin-4-yl)ethyll-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo [1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy) phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
piperidin-4-ylmethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylicacid,
1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4-carboxylicacid,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-[2-(4-[methyl[(5-oxooxolan-2 yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
methyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo [1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-([[4 (methylsulfanyl)phenyl]methyl]amino)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(2-oxooxan-4 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4 ylmethyl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(4-methylpiperazin-1 yl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[(4-methylpiperazin-1 yl)methyl]piperidin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxo-2,5 dihydrofuran-3-yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-[methyl[(5-oxo-2,5 dihydrofuran-3-yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
3-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]propanoicacid,
tert-butyl (3R,4R)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3S,4S)-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-3-hydroxypiperidine-1-carboxylate, (3R,4R)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate,
tert-butyl (3S,4S)-3-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]-4-hydroxypiperidine-1-carboxylate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1- [(3R,4R)-3-hydroxypiperidin-4 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy) phenyl]-1-[(3S, 4S)-3-hydroxypiperidin-4 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3R,4R)-4-hydroxypiperidin-3 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(3S, 4S)-4-hydroxypiperidin-3 yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
ethyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetate,
2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3 amido]-1H-pyrazol-1-yl]ethyl)(pyridin-3-ylmethyl)amino]acetic,
ethyl 2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetate,
2-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine 3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl]amino]acetic acid,
ethyl 2-(4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]piperidin-1-yl)acetate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(1,3-oxazol-2 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[(pyridin-3 ylmethyl)amino]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(methylamino)propyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(dimethylamino)propyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2S)-2-(ethylamino)propyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2 (methylsulfanyl)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(propan-2 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4 (cyclopropylmethyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2,4-dimethylpiperazin-1-yl)-2 oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,4-dimethylpiperazin-1-yl)-2 oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(2,2,4 trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-(3,3,4 trimethylpiperazin-1-yl)ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2 (dimethylamino)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(1,3-oxazol-2 ylmethyl)piperazin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(5-oxooxolan-2 yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-oxo-2-[4-[(5-oxooxolan-2 yl)methyl]piperazin-1-yl]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4 [(methylcarbamoyl)methyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1R)-1 phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[[(1S)-1 phenylethyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, methyl 2-[(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]ethyl)amino]acetate,
methyl (2S)-2-amino-4-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]butanoate,
(1-methylpiperidin-4-yl)methyl1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, (1-methylpiperidin-4-yl)methyl1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)-4-methylpiperidine-4 carboxylate,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[methyl[(5-oxooxolan-2 yl)methyl]amino]ethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ethyl 3-[[1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidin-4-yl](methyl)amino]propanoate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-oxo-2-[4-(5-oxooxolan-3 yl)piperazin-1-yl]ethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4-yl)piperidin 1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(morpholin-4-yl)but-2-en 1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[(2E)-4-(4-methylpiperazin-1 yl)but-2-en-1-yl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-(methylthio)ethyl 2-(2-(3-(5-chloro-2-(difluoromethoxy)phenyl)-4 (pyrazolo[1,5-a]pyrimidine-3-carboxamido)-1H-pyrazol-1-yl)ethylamino)acetate, ethyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-hydroxy-3-morpholinopropyl) 1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-((S)-3-cyano-1,4'-bipiperidin l'-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(1-methylpiperidin-4 ylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2 cyanoethyl)(methyl)amino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2 cyanoethylamino)cyclohexylidene)ethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(piperidin-4-yl)-1H-1,2,3 triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-((1-(1-(tetrahydro-2H-pyran-4 yl)piperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide,
and
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1 cyanocyclopropyl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
or salt thereof.
3.              The compound according to claim 1 selected from the group consisting of:
2-amino-N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(4-piperidyl)pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aS,6aR)-2-methyl-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl] 2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[1-[2-[(3aR,6aS)-2-(2,2,2-trifluoroethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4 c]pyrrol-5-yl]-2-oxo-ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2 cyanoethyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(dimethylamino)-1 piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2 phenylethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[1-[2-[4-[benzyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]-3-[5-chloro-2 (difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[methyl(2,2,2 trifluoroethyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[(2,2-difluoro-2-phenyl ethyl)-methyl-amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-[2,2 difluoropropyl(methyl)amino]-1-piperidyl]-2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[4-[methyl(2,2,2 trifluoroethyl)amino]-1-piperidyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-(4-methylpiperazin-1-yl)thiazol-5 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[4-[5-chloro-2-(difluoromethoxy)phenyl]-2-[3-(dimethylamino)prop-1 ynyl]thiazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-ethylpiperazin-1-yl)-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(4-hydroxy-1-piperidyl)-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(3,6-dihydro-2H-pyridin-1-yl) 2-oxo-ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-(2 methoxyethylamino)ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[2-(benzylamino)ethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,
2-(dimethylamino)ethyl 1-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4 [pyrazolo [1,5-a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperidine-4-carboxylate, N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4 ylmethyl)piperidin-1-yl]-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide,
N-[3-[5-chloro-2-(difluoromethoxy)phenyl]-1-(2-[4-[2 (methylsulfanyl)ethyl]piperazin-1-yl]-2-oxoethyl)-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide,
ethyl 2-[4-(2-[3-[5-chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo[1,5 a]pyrimidine-3-amido]-1H-pyrazol-1-yl]acetyl)piperazin-1-yl]acetate,
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(2-cyano-2 methylpropylamino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5 a]pyrimidine-3-carboxamide, and
N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-(((1 cyanocyclopropyl)methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4 yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,
or a salt thereof.
4.              The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-[4-[2-cyanoethyl(methyl)amino]-1-piperidyl]-2-oxo ethyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
5.              The compound according to claim 1, which is 2-amino-N-[1-(3-aminocyclobutyl) 3-[5-chloro-2-(difluoromethoxy)phenyl]pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide, or a salt thereof.
6.              The compound according to claim 1, which is N-[1-[2-(benzylamino)ethyl]-3-[5 chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3 carboxamide, or a salt thereof.
7.              The compound according to claim 1, which is N-[1-[2-(4-benzylpiperazin-1-yl) 2-oxoethyl]-3-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl]pyrazolo[1,5 a]pyrimidine-3-carboxamide, or a salt thereof.
8.              The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-(2-[[(3-hydroxyphenyl)methyl]amino]ethyl)-1H-pyrazol-4 yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
9.              The compound according to claim 1, which is methyl 2-[[1-(2-[3-[5-chloro-2 (difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a] pyrimidine-3-amido]-1H-pyrazol-1 yl]acetyl)piperidin-4-yl]amino]acetate, or a salt thereof.
10. The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-[4-(5-hydroxy-2-oxopiperidin-1-yl)piperidin-1-yl]-2 oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
11. The compound according to claim 1, which is 2-(dimethylamino)ethyl 1-(2-[3-[5 chloro-2-(difluoromethoxy)phenyl]-4-[pyrazolo [1,5-a]pyrimidine-3-amido]-1H-pyrazol 1-yl]acetyl)piperidine-4-carboxylate, or a salt thereof.
12. The compound according to claim 1, which is 1-(2-[3-[5-chloro-2 (difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1 yl]acetyl)piperidine-4-carboxylic acid, or a salt thereof.
13. The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-([[4-(methylsulfanyl)phenyl]methyl]amino)ethyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
14. The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-(4-[methyl[(5-oxo-2,5-dihydrofuran-3 yl)methyl]amino]piperidin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine 3-carboxamide, or a salt thereof.
15. The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-[4-(morpholin-4-yl)piperidin-1-yl]-2-oxoethyl]-1H pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
16. The compound according to claim 1, which is ethyl 2-[4-(2-[3-[5-chloro-2 (difluoromethoxy)phenyl]-4-[pyrazolo[1,5-a]pyrimidine-3-amido]-1H-pyrazol-1 yl]acetyl)piperazin-1-yl]acetate, or a salt thereof.
17. The compound according to claim 1, which is N-(3-(5-chloro-2 (difluoromethoxy)phenyl)-1-((1-(1-(tetrahydrofuran-3-yl)piperidin-4-yl)-1H-1,2,3-triazol 4-yl)methyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide,orasaltthereof.
18. The compound according to claim 1, which is N-[3-[5-chloro-2 (difluoromethoxy)phenyl]-1-[2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-2-oxoethyl] 1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, or a salt thereof.
19. A pharmaceutical composition comprising a compound of any one of claims 1 to 18, or a salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
20.            A method for the treatment of an inflammatory disease in a patient, comprising administering to the patient a therapeutically effective amount of a compound of any one of claims I to 18, or a salt thereof, or a pharmaceutical composition of claim 19.
21.            Use of a compound of any one of claims 1 to 18, or a salt thereof, for the preparation of a medicament for the treatment of an inflammatory disease.
22.            The method of claim 20 or the use of claim 21, wherein the inflammatory disease is asthma.
F. Hoffmann-La Roche AG
Patent Attorneys for the Applicant/Nominated Person
SPRUSON & FERGUSON