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1. (AU2007245164) Anti-IGF-IR antibodies and uses thereof

Office : Australia
Application Number: 2007245164 Application Date: 28.03.2007
Publication Number: 2007245164 Publication Date: 06.11.2008
Publication Kind : A1
Prior PCT appl.: Application Number:US2007007664 ; Publication Number: Click to see the data
IPC:
C07K 16/28
A61K 39/395
C07K 16/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
CPC:
A61K 2039/505
Applicants: Biogen Idec MA Inc.
Inventors:
Agents: Spruson & Ferguson
Priority Data: 60/786,347 28.03.2006 US
60/876,554 22.12.2006 US
Title: (EN) Anti-IGF-IR antibodies and uses thereof
Abstract: front page image
(EN) The invention relates to antibodies which bind to insulin like growth factor receptor -1 (IGF-IR) and uses thereof, in particular in the diagnosis and treatment of cancer. Specific human and murine monoclonal antibodies which inhibit IGF-lR-mediated pro-survival and tumor proliferation pathways, and variants, fragments, and derivatives thereof are provided. Also provided are specific human and murine monoclonal antibodies which block the ability of the ligands, insulin like growth factor 1 (IGF-I) and insulin like growth factor 2 (IGF-2) to bind to IGF-IR, as well as fragments, variants and derivatives of such antibodies. The invention also includes polynucleotides encoding the above antibodies or fragments, variants or derivatives thereof, as well as vectors and host cells comprising such polynucleotides. The invention further includes methods of diagnosing and treating cancer using antibodies of the invention.
Also published as:
NO20084521NZ571964UAa200812599MXMX/a/2008/012146KR1020080113268SG146164
EP1999149JP2009532027IL194266CN101415728CA2646406EA200802061
ID049.0429IN8061/DELNP/2008WO/2007/126876