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1. (AU2006259664) Self-buffering protein formulations

Office : Australia
Application Number: 2006259664 Application Date: 08.06.2006
Publication Number: 2006259664 Publication Date: 06.12.2007
Publication Kind : A1
Prior PCT appl.: Application Number:US2006022599 ; Publication Number: Click to see the data
IPC:
A61K 39/395
C12P 21/08
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
CPC:
A61K 39/3955
A61K 9/08
A61K 39/39591
A61K 47/02
A61K 47/10
A61K 47/26
C07K 16/00
C07K 16/241
C07K 16/2803
C07K 16/2827
C07K 16/2851
C07K 16/2866
C07K 16/2875
C07K 2317/21
C07K 2317/565
C07K 2317/94
Applicants: Amgen Inc.
Inventors:
Agents: FPA Patent Attorneys Pty Ltd
Priority Data: 60/690,582 14.06.2005 US
Title: (EN) Self-buffering protein formulations
Abstract: front page image
(EN) The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are suitable for veterinary and human medical use. The self-buffering protein formulations are substantially free of other buffering agents, stably maintain pH for the extended time periods involved in the distribution and storage of pharmaceutical proteins for veterinary and human medical use. The invention further provides methods for designing, making, and using the formulation. In addition to other advantages, the formulations avoid the disadvantages associated with the buffering agents conventionally used in current formulations of proteins for pharmaceutical use. The invention in these and other respects can be productively applied to a wide variety of proteins and is particularly useful for making and using self-buffering formulations of pharmaceutical proteins for veterinary and medical use, especially, in particular, for the treatment of diseases in human subjects.
Also published as:
MXMX/a/2007/015476KR1020080031684IL188102SG162788EP1909831ZA2008/00338
JP2008543839US20080311078BRPI0611901JP2013047261CN101217979CA2610839
EA200800050JP2016053061AU2012272950AU2015242973AU2017202889IN5286/CHENP/2007
JP2018048196EP3351269WO/2006/138181