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1. (AU2005333515) Wortmannin analogs and methods of using same in combination with chemotherapeutic agents

Office : Australia
Application Number: 2005333515 Application Date: 11.07.2005
Publication Number: 2005333515 Publication Date: 15.02.2007
Publication Kind : B2
Prior PCT appl.: Application Number:US2005024429 ; Publication Number: Click to see the data
IPC:
C07D 311/78
A61K 31/35
A61K 31/40
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Ring systems having three or more relevant rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
CPC:
C07D 311/78
A61K 31/337
A61K 31/35
A61K 31/366
A61K 31/40
A61K 31/4025
A61K 31/7072
A61K 33/24
A61K 45/06
C07D 311/94
Applicants: Arizona Board of Regents, Acting on Behalf of The University of Arizona
Prolx Pharmaceuticals Corp.
University of Pittsburgh
Inventors:
Agents: Pizzeys Patent and Trade Mark Attorneys Pty Ltd
Priority Data: 60/586,687 09.07.2004 US
Title: (EN) Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
Abstract: front page image
(EN) wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment of cancer and tumor formation in a subject are described herein, ehich may be administered with other chemotherapeutic agents in the treatment of cancer.
Also published as:
MXMX/a/2007/000319AU2005333515EP1901738EP2301533JP2009500408CA2578336
WO/2007/008200