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1. AU2003238512 - Method for producing 3,4-dichloro-n-(2-cyano-phenyl)-5-isothiazole carboxamide

Office Australia
Application Number 2003238512
Application Date 17.06.2003
Publication Number 2003238512
Publication Date 11.09.2003
Publication Kind A
IPC
C07D 275/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
275Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings
02not condensed with other rings
C07D 275/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
275Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings
02not condensed with other rings
03with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
CPC
C07D 275/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
275Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
02not condensed with other rings
03with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applicants BAYER CROPSCIENCE AKTIENGESELLSCHAFT
Inventors Himmler, Thomas
Priority Data 10228731 27.06.2002 DE
Title
(EN) Method for producing 3,4-dichloro-n-(2-cyano-phenyl)-5-isothiazole carboxamide
Abstract
(EN)
The invention relates to a novel one-pot method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) isatoic acid anhydride is reacted with ammonia gas in the presence of dimethylformamide, b) the anthranilic acid amide thus obtained is reacted with 3,4-dichloro-isothiazole carboxylic acid chloride, without being previously isolated, in the presence of an acid acceptor and in the presence of dimethylformamide, and c) the N-[2-(aminocarbonyl)-phenyl]-3,4-dichloro-isothiazole carboxamide thus obtained is reacted with thionyl chloride, phosphorus oxychloride, phosgene or chloromethylene-dimethylammonium chloride, without being previously isolated, in the presence of dimethylformamide.