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1. AU2001294547 - Substituted urea neuropeptide y y5 receptor antagonists

Office
Australia
Application Number 2001294547
Application Date 12.09.2001
Publication Number 2001294547
Publication Date 20.12.2001
Publication Kind A
IPC
C07D 205/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
A61K 31/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A61K 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 31/397
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
397having four-membered rings, e.g. azetidine
A61K 31/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4025not condensed and containing further heterocyclic rings, e.g. cromakalim
Applicants Schering Corporation
Inventors Greenlee, William J.
Huang, Ying
Kelly, Joseph M.
Mccombie, Stuart W.
Stamford, Andrew W
Wu, Yusheng
Priority Data 60232255 14.09.2000 US
Title
(EN) Substituted urea neuropeptide y y5 receptor antagonists
Abstract
(EN)
Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R1 is H or (C1-C6)alkyl; R2 is H,(C1-C6)alkyl,(C3-C9)cycloalkyl or (C3-C7)cycloalkyl(C1-C6)alkyl; R3 is (c), (d), (e), (f), (g), (h) or (i); R4 is 1-3 substituents independently selected from the group consisting of H, -OH, halogen, haloalkyl,(C1-C6) alkyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkyl (C1-C6) alkyl, -CN, -O(C1-C6) alkyl, -O(C3-C7) cycloalkyl, -O(C1-C6) alkyl (C3-C7) cycloalkyl, -S(C1-C6) alkyl, -S(C3-C7) cycloalkyl, -S(C1-C6) alkyl(C3-C7) cycloalkyl, -NH2, -NR9R10, -NO2, -CONH2, -CONR9R10 and NR2COR10; or where applicable, a geometric or optical isomer or a racemic mixture thereof, are claimed, as well as additional novel compounds; also claimed are pharmaceutical compositions and methods of using the aforesaid compounds in the treatment of obesity, eating disorders such as hyperphagia and diabetes.