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1. AU2001277055 - Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau

Office
Australia
Application Number 2001277055
Application Date 19.07.2001
Publication Number 2001277055
Publication Date 18.10.2001
Publication Kind A
IPC
A61K 38/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
Applicants Pepgen Corporation
Inventors Liu, Chih-Ping
Sokawa, Yoshihiro
Priority Data 2000317160 17.10.2000 JP
60/219,128 19.07.2000 US
Title
(EN) Composition for treatment of and method of monitoring hepatitis c virus using interferon-tau
Abstract
(EN) A method of monitoring treatment of HCV by oral administration of ovine IFN-$g(t) is disclosed. The method includes measuring the blood levels of 2', 5'-oligoadenylate synthetase prior to and after such oral administration, and if necessary, adjusting the dose of IFN-$g(t) until a measurable increase in blood 2', 5'-oligoadenylate synthetase level, relative to the level observed prior to administration, is observed. Also disclosed are oral-delivery compositions for use in treating HCV in an HCV-infected patient comprising ovine IFN-$g(t), in a dosage effective to stimulate bloodstream levels of 2', 5'-oligoadenylate synthetase.
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