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1. AU2001267698 - Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

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Australia
Application Number 2001267698
Application Date 02.07.2001
Publication Number 2001267698
Publication Date 27.09.2001
Publication Kind B2
IPC
C07K 1/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
06using protecting groups or activating agents
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 5/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
C07K 5/083
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
083the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
Applicants Pharma Mar, S.A.
Inventors Cuevas, Carmen
Cuevas, Felix
Gallego, Pilar
Manzanares, Ignacio
Mendez, Paloma
Munt, Simon
Polanco, Concepcion
Rodriguez, Ignacio
Agents Griffith Hack
Priority Data 0016148.9 30.06.2000 GB
0103750.6 15.02.2001 GB
Title
(EN) Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them
Abstract
(EN) The invention provides aplidine derivatives and synthetic methods. They are represented by the formula: where the different symbols have the meaning indicated in the description.
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