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1. AU2001236739 - Improved sialylation of glycoproteins

Office
Australia
Application Number 2001236739
Application Date 07.02.2001
Publication Number 2001236739
Publication Date 10.05.2001
Publication Kind A
IPC
C12N 9/90
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90Isomerases (5.)
C12P 21/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
Applicants Genentech Inc.
Inventors Ryll, Thomas
Priority Data 60/181,074 08.02.2000 US
60/191,529 23.03.2000 US
Title
(EN) Improved sialylation of glycoproteins
Abstract
(EN) The present invention provides for cells and processes for producing glycoproteins having enhanced sialyation. The invention also provides for nucleic acid sequences encoding UDP-GlcNac 2-epimerases or modified UDP-GlcNac 2-epimerases. The modified UDP-GlcNac 2-epimerases have reduced binding to sialic acid.
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