AU2001235285 Method of modulating glycosylation pathways

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Application Number 2001235285

Application Date 26.02.2001

Publication Number 2001235285

Publication Date 10.05.2001

Publication Kind A

IPC

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Applicants University of Guelph

Inventors Skinner, Mhairi A.
Wildeman, Alan G.

Priority Data 60/184,651 24.02.2000 US

Title

(EN) Method of modulating glycosylation pathways

Abstract

(EN) The invention can be summarized as follows. A method of modulating glycosylation of proteins, in a cell, preferably where the cell is in an animal where the method comprises administering an effective amount of a substance having 16K activity, to an animal in need thereof. The invention relates to a method of modulating tumor-related glycosylation of cell surface receptors and may be used to suppress the invasive growth, migration, or metastasis of tumor cells.

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14	Hydrolases (3.)

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants
71	for growth factors; for growth regulators

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
12	Genes encoding animal proteins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides

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1. AU2001235285 - Method of modulating glycosylation pathways