Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (AU2000240570) Pyrrolopyrimidines as tyrosine kinase inhibitors

Office : Australia
Application Number: 2000240570 Application Date: 29.03.2000
Publication Number: 2000240570 Publication Date: 06.07.2000
Publication Kind : A
Prior PCT appl.: Application Number:US2000008593 ; Publication Number: Click to see the data
IPC:
C07D 487/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants: Knoll Gesellschaft MIT Beschraenkter Haftung
Inventors: Arnold, Lee D.
Calderwood, David
Hirst, Gavin C.
Johnston, David N.
Munschauer, Rainer
Rafferty, Paul
Priority Data:
Title: (EN) Pyrrolopyrimidines as tyrosine kinase inhibitors
Abstract:
(EN) Chemical compounds having structural formula (I), and physiologically acceptable salts and metabolites thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases, whose activity is inhibited by these chemical compounds, are involved in immunologic, hyperproliferative, or angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyper proliferative disorders, rheumatiod arthritis, disorders of the immune system, transplant rejections and ifplammatory disorders.
Also published as:
WO/2001/072751