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1. (AU2000075970) Imaging of drug accumulation as a guide to antitumor therapy

Office : Australia
Application Number: 75970/00 Application Date: 21.09.2000
Publication Number: 2000075970 Publication Date: 21.06.2001
Publication Kind : A
Prior PCT appl.: Application Number:US2000025833 ; Publication Number: Click to see the data
IPC:
A61K 51/04
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
Applicants: Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services, The
Inventors: Anderson, Lawrence
Collins, Jerry M.
Klecker, Raymond N.
Priority Data: 60/155061 21.09.1999 US
Title: (EN) Imaging of drug accumulation as a guide to antitumor therapy
Abstract:
(EN) The present invention describes the use of radio-labeled antitumor drugs in the treatment of solid tumors by the method of administering a radio-labelled anticancer drug to a patient and imaging at least a part of the patient using Positron Emission Tomography imaging. The method is used to monitor delivery of antitumor drugs to tumors and may be used to predict the effectiveness of therapy with a particular antitumor drug or combination of antitumor drugs, to assess the effectiveness of modulators of cellular accumulation, to individualize therapy and to evaluate the effectiveness of antitumor drugs with respect to particular cancers. Particularly preferred drugs are labeled taxanes, e.g., 11C-paclitaxel and 11C-docetaxel, labeled anthracyclines, e.g., 11C-doxorubicin and 11C-epirubicin, and other radio-labeled drug, e.g. 11C-topotecan and 11C-mitoxantrone. The invention further describes antitumor drugs labeled with the radioactive label 11C and methods of preparing radio-labeled drugs.
Also published as:
US7141234WO/2001/021219