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1. AU1997024238 - Methods for treating bipolar mood disorder associated with markers on chromosome 18Q

Office
Australia
Application Number 24238/97
Application Date 27.03.1997
Publication Number 1997024238
Publication Date 18.12.1997
Publication Kind A
IPC
C12N 15/09
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12Q 1/68
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1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
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61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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CPC
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2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/172
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2600Oligonucleotides characterized by their use
172Haplotypes
Applicants Regents of the University of California, The
University of Costa Rica, The
Inventors Barondes, Samuel H.
Freimer, Nelson B.
Leon, Pedro
Reus, Victor I.
Sandkuijl, Lodewijk A.
Agents PHILLIPS ORMONDE FITZPATRICK
Priority Data 60/014498 29.03.1996 US
60/023438 23.08.1996 US
Title
(EN) Methods for treating bipolar mood disorder associated with markers on chromosome 18Q
Abstract
(EN) The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the long arm of chromosome 18 between markers D18S469 and D18S554, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in the 18q22-q23 region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes. Isolated polynucleotides useful for genetic linkage analysis of BP-I and methods for obtaining such isolated polynucleotides are also described.