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1. (AU1991090500) Novel 14-(n-substituted aminomethyl)eburnane derivatives, process for their preparation and compositions containing them

Office : Australia
Application Number: 90500/91 Application Date: 06.12.1991
Publication Number: 1991090500 Publication Date: 05.11.1992
Publication Kind : A
Prior PCT appl.: Application Number:HU1991000051 ; Publication Number: Click to see the data
IPC:
C07D 461/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
461
Heterocyclic compounds containing indolo [3, 2, 1-d, e] pyrido [3, 2, 1-i, j] [1, 5]-naphthyridine ring systems, e.g. vincamine
CPC:
C07D 461/00
Applicants: Richter Gedeon Vegyeszeti Gyar Rt
Inventors: Bodo, Mihaly
Csomor, Katalin
Czibula, Laszlo
Gere, Aniko
Karpati, Egon
Kiss, Bela
Kreidl, Janos
Lapis, Erzsebet
Laszy, Judit
Nemes, Andras
Palosi, Eva
Sarkadi, Adam
Szabo, Sandor
Szentirmay, Zsolt
Szombathelyi, Zsolt
Szporny, Laszlo
Visky, Gyorgy
Priority Data: 8107/90 07.12.1990 HU
Title: (EN) Novel 14-(n-substituted aminomethyl)eburnane derivatives, process for their preparation and compositions containing them
Abstract:
(EN) The invention relates to novel, optically active $i(cis) and $i(trans) 14-(N-substituted aminomethyl)eburnane derivatives of formula (I), wherein R1 stands for hydrogen, a C1-6alkyl or C2-6alkenyl group; R2 means a C1-6alkyl, C2-6alkenyl or a hydroxy-C1-6alkyl group; or R1 and R2 represent together with the adjacent nitrogen atom to which they are attached, a 5 to 7-membered saturated ring, optionally containing one oxygen atom and/or one optionally substituted nitrogen atom as heteroatom; and n is 2 or 3, as well as pharmaceutically acceptable salts of these compounds. The compounds of the invention possess an antioxidative (lipid peroxidation-inhibiting) effect and therefore, they are useful for treating diseases connected with lipid peroxidation, such as ischaemic intestinal diseases, myocardial ischaemia, ischaemic cerebrovascular disturbances as well as some diseases of connective tissues, e.g. rheumatoid arthritis. The compounds of the invention are also suitable for treating or preventing cognitive disorders.
Also published as:
WO/1992/010495