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1. (AU1991071539) Synthesis of rotavirus receptor saccharides

Office : Australia
Application Number: 71539/91 Application Date: 05.12.1990
Publication Number: 1991071539 Publication Date: 17.09.1992
Publication Kind : A
Prior PCT appl.: Application Number:US1990007121 ; Publication Number: Click to see the data
IPC:
A61K 31/70
C07H 13/04
C07H 15/04
C07H 15/06
C07H 15/18
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
06
being a hydroxyalkyl group esterified by a fatty acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
18
Acyclic radicals, substituted by carbocyclic rings
CPC:
C07H 13/04
C07H 15/04
C07H 15/06
C07H 15/18
Applicants: Glycomed Incorporated
Inventors: Abbas, Saeed A
Dasgupta, Falguni
Laine, Roger A.
Nashed, Mina A
Srnka, Cheryl A
Priority Data: 450026 13.12.1989 US
554005 17.07.1990 US
Title: (EN) Synthesis of rotavirus receptor saccharides
Abstract:
(EN) Saccharides which are active as rotavirus receptor sites are disclosed. These saccharides are synthetically produced sugar derivatives recognized by the antireceptor of a rotavirus. The molecules are useful in studying the interaction between the rotavirus antireceptor and most receptor sites so as to develop drugs useful in blocking the connection between such viruses and the host cells. Further, the molecules can be modified in order to increase the degree to which they attract the antireceptor sites of the virus and/or modified by binding to them antiviral compounds which are effective in destroying the virus once the receptor molecule binds to the virus. Synthetic receptor molecules recognizable by a rotavirus are obtainable by the synthesis methods disclosed.
Also published as:
WO/1991/008748