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1. (AR074863) PROCESO Y COMPUESTOS INTERMEDIOS PARA PREPARAR UN INHIBIDOR DE PROTEASA MACROCICLICO DEL VHC

Office : Argentina
Application Number: P090105059 Application Date: 22.12.2009
Publication Number: 074863 Publication Date: 16.02.2011
Publication Kind : A1
IPC:
C07D 311/06
C07D 417/04
A61K 31/4709
A61P 31/12
C07D 453/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
06
with oxygen or sulfur atoms directly attached in position 2
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4709
Non-condensed quinolines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
04
having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
CPC:
C07C 67/475
C07C 231/12
C07C 235/40
C07C 2601/08
C07D 307/33
C07D 417/04
C07D 453/04
Applicants: ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC.
Inventors:
Priority Data: 08172691.1 23.12.2008 EP
Title: (ES) PROCESO Y COMPUESTOS INTERMEDIOS PARA PREPARAR UN INHIBIDOR DE PROTEASA MACROCICLICO DEL VHC
Abstract:
(ES) La presente también se refiere a procesos que involucran esta sal. Reivindicación 1: Un proceso para preparar un compuesto de fórmula (4), comenzando a partir de una sal de cinconidina de fórmula (1), la cual se hace reaccionar con N-metil-hexenamina (NMHA) de fórmula (2) en una reacción de formación de amida para proporcionar la amida de lactona bicíclica de fórmula (3), en donde el grupo lactona se abre para proporcionar el producto deseado de fórmula (4), donde R1 es alquilo C1-4. Reivindicación 14: La sal de cinconidina de fórmula (1).
Also published as:
IL213246MXMX/a/2011/006764EP2382198JP2012513381US20110257403CN102264715
RU2011130895CA2745565ES2429013PT2382198MX2011006764US20150080577
KR1020110099048BRPI0923393RU0002588132DK2382198AU2009331530IN1505/MUMNP/2011
RU2016120007WO/2010/072742