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1. AR086791 - MODULADORES ALOSTERICOS POSITIVOS DEL RECEPTOR DE ACETILCOLINA NICOTINICO

Office
Argentina
Application Number P120102330
Application Date 28.06.2012
Publication Number 086791
Publication Date 22.01.2014
Publication Kind A1
IPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 213/00
A61P 231/00
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants H. LUNDBECK A/SH. LUNDBECK A/S
Priority Data PA 2011 00498 01.07.2011 DK
PA 2011 00514 01.07.2011 DK
Title
(ES) MODULADORES ALOSTERICOS POSITIVOS DEL RECEPTOR DE ACETILCOLINA NICOTINICO
Abstract
(ES)
La presente se refiere a compuestos útiles en terapia, a composiciones que comprenden dichos compuestos, y a métodos de tratamiento de enfermedades, que comprenden la administración de dichos compuestos. Los compuestos referidos son moduladores alostéricos positivos (PAM) del receptor de acetilcolina nicotínico a7. Los compuestos son útiles para el tratamiento de la enfermedad de Alzheimer, demencia senil y otras, epilepsia, amnesia postraumática. Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), donde A⁴ es C-R⁴ o N, A⁵ es C-R⁵ o N, y A⁶ es C-R⁶ o N, siempre que por lo menos uno de A⁴, A⁵ o A⁶ sea N, y no más de dos de A⁴, A⁵ y A⁶ sean N; R¹ es fenilo o heteroarilo; donde dicho fenilo o heteroarilo está opcionalmente sustituido con uno o más sustituyentes R¹¹, donde cada R¹¹ es individualmente seleccionado de alquilo C₁₋₆, halógeno, hidroxi, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, ciano, alquil C₁₋₆sulfonilo, -S(O)₂NH₂ y -NR¹²R¹³, donde R¹² y R¹³ representan, de manera independiente, hidrógeno o alquilo C₁₋₆; R² se selecciona de H, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, halógeno y ciano; R³, R⁴, R⁵, R⁶ y R⁷ se seleccionan, de manera independiente entre sí, de H, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, halógeno, ciano y -NR⁹R¹⁰, donde R⁹ y R¹⁰ representan, de manera independiente, hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, haloalquilo C₁₋₆ o fenilo; R⁸ se selecciona de H, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, alcoxi C₁₋₆, halógeno, ciano y fenilo; y una de sus sales farmacéuticamente aceptables.

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