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1. (AR011093) COMPUESTOS DERIVADOS DE SULFONIL UREA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y PROCEDIMIENTO PARA SU USO.

Office : Argentina
Application Number: P980100358 Application Date: 27.01.1998
Publication Number: 011093 Publication Date: 02.08.2000
Publication Kind : A1
IPC:
C07C 311/59
C07C 311/60
C07D 317/26
C07D 209/08
C07D 333/34
C07D 335/06
C07D 307/22
C07D 307/18
C07D 409/04
C07D 233/42
C07D 235/28
A61K 31/17
A61K 31/335
A61K 31/40
A61K 31/38
A61K 31/34
A61K 31/415
A61K 31/64
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
50
Compounds containing any of the groups X being a hetero atom, Y being any atom
52
Y being a hetero atom
54
either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
57
having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
59
having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
50
Compounds containing any of the groups X being a hetero atom, Y being any atom
52
Y being a hetero atom
54
either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
57
having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
60
having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
10
not condensed with other rings
14
with substituted hydrocarbon radicals attached to ring carbon atoms
26
Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
08
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
333
Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02
not condensed with other rings
04
not substituted on the ring sulfur atom
26
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Hetero atoms other than halogen
34
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
335
Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
04
condensed with carbocyclic rings or ring systems
06
Benzothiopyrans; Hydrogenated benzothiopyrans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
18
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
22
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
18
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
04
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Oxygen or sulfur atoms
42
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
235
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02
condensed with carbocyclic rings or ring systems
04
Benzimidazoles; Hydrogenated benzimidazoles
24
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
28
Sulfur atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
17
having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
38
having sulfur as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
64
Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
CPC:
C07D 307/64
C07C 311/60
C07C 317/14
C07C 323/67
C07C 2601/02
C07C 2601/04
C07C 2601/08
C07C 2601/14
C07C 2602/10
C07D 209/08
C07D 317/18
C07D 333/34
Applicants: PFIZER INC.
Inventors:
Priority Data: 60/036979 29.01.1997 US
Title: (ES) COMPUESTOS DERIVADOS DE SULFONIL UREA, COMPOSICION FARMACEUTICA QUE LOS CONTIENE Y PROCEDIMIENTO PARA SU USO.
Abstract:
(ES) Un compuesto de la fórmula I, o una sal aceptable farmaceúticamente de la misma, en la que: R1 es (C1-C6)alquilo opcionalmente sustituido por( C1-C6)alquilamino, (C1-C6)alquiltio, (C1-C6)alcoxi, trifuorometilo, (C6-C10) arilo, (C3-C9)heteroarilo,(C6-C10)arilamino, (C6-C10)ariltio, (C9-C10)ariloxi,(C3-C9)heteroarilamino, (C3-C9)heteroariltio, (C3-C9)heteroariloxi, (C6-C1O) aril(C6-C10)-arilo, (C3-C6)cicloalquilo, hidroxi(C1-C6)alquilo,(C1-C6)alquil(hidroximetileno), piperacinilo, (C6-C10)aril(C1-C6)alcoxi, (C3-C9)heteroaril (C1-C6)acilamino, (C1-C6)aciltio, (C1-C6)aciloxi, (C1-C6)alquilsulfinilo, (C6-C10)arilsulfinilo, (C1-C6)alquilsulfonilo, (C6-C10) arilsulfonilo, amino, (C1-C6)alquilamino o ((C1-C6)alquil)2 amino; oR1 y R2son cada uno independientemente un grupo de la fórmula II en la que las líneas de trazos representan enlaces dobles opcionales; n es 0, 1, 2 o 3; A, B, D, E yG son cada uno de ellos independientemente oxígeno, azufre, nitrógeno o CR5R6; Fórmula III en la que: s es 0 a 6, t es 0 o 1, x es oxígeno o NR8 en el que R8es hidrógeno, (C1-C6)alquilo o (C3-C7)cicloalquil (C1-C6)alquilo; y es hidrógeno, hidroxi, (C1-C6)alquilo, opcionalmente sustituido por halo, hidroxio ciano; (C1-C6)alcoxi, ciano, (C2-C6)alquinilo, (C6-C10)arilo en el que el grupo arilo está opcionalmente sustituido por halo, hidroxi, carboxi, (C1-C6)alquilo, (C1-C6)alcoxi; perfluoro (C1-C6)alquilo, (C1-C6)alcoxi(C1-C6)alquilo o NR9R10 o un grupo de la fórmula IV en la que: u es 0, 1 o 2; R19 es hidrógeno,(C1-C6)alquilo o perfluoro (C1-C6)alquilo; R20 es hidrógeno, (C1-C6)alquilo, (C1-C6)carboxialquilo o (C6-C10)aril(C1-C6)alquilo, o un grupo de la fórmula Ven la que: a es 0, 1 o 2; b es 0 o 1; c es 1, 2 o 3; d es 0 o 1; e es 0, 1 o 2; J y L son cada uno de ellos independientemente oxígeno o azufre; R21 es
Also published as:
CZPV1999-2575IS5099NO19993658SK98299TR1999/01816YUP-337/99
MXPA/a/1999/007030KR1020000070541SG65991VN4111IL130855MA26468
EP0964849EP1270554EP1270565US6166064JP2000511200 CN1245490
CA2279186EA199900603DE000069722663DE000069729762PT964849PT1270565
NZ336248AU1998052340VN4111MYPI 98000291BG103597WO/1998/032733