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1. KR1018814410000* - COMPOSITION BASED ON POLYPHARMACOPHORE PROPERTY FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL ADIPONECTIN LEVELS

Office
Republic of Korea
Application Number 1020170010023
Application Date 20.01.2017
Publication Number 1018814410000*
Publication Date 24.07.2018
Grant Number 1018814410000
Grant Date 24.07.2018
Publication Kind B1
IPC
A61K 31/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61K 31/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
CPC
A61K 31/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
52Purines, e.g. adenine
A61K 31/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
A61K 31/381
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
Applicants 서울대학교산학협력단
Inventors JEONG, LAK SHIN
NOH, MIN SOO
정낙신
노민수
Agents 리앤목특허법인
Title
(EN) COMPOSITION BASED ON POLYPHARMACOPHORE PROPERTY FOR TREATING DISEASES ASSOCIATED WITH ABNORMAL ADIPONECTIN LEVELS
(KO) 다중 약리단 특성에 기반한 비정상적 아디포넥틴 관련 질환 치료용 조성물
Abstract
(EN)
The present invention relates to a compound having a pharmacophore profile of an A_3AR regulator, a PPAR gamma; partial agonist, and a PPAR delta; antagonist, and to a composition for treating diseases associated with abnormal adiponectin levels, comprising the same as an effective component. Accordingly, due to pharmacophore effects of A_3AR, PPAR gamma;, and PPAR delta;, the compound of the present invention can increase adiponectin, and can increase insulin sensitivity, and thus can be used beneficially in the treatment of diseases associated with abnormal adiponectin levels, including inflammations, atherosclerosis, heart diseases, autoimmune diseases, infectious diseases, allergies, kidney diseases, liver diseases, cancer, obesity, or diabetes. COPYRIGHT KIPO 2018

(KO)
본 발명은 A AR 조절자, PPARγ 부분 효능제, 및 PPARδ 길항제의 다중 약리단 프로필을 갖는 화합물 및 이를 유효성분으로 포함하는 비정상적 아디포넥틴 수준과 연관된 질환을 치료하기 위한 조성물에 관한 것이다. 따라서, 본 발명의 화합물은 A AR, PPARγ 및 PPARδ에 대한 다중 약리단 효능에 의해 아디포넥틴을 증가시키고, 인슐린-감수성을 증가시킬 수 있으므로, 염증, 죽상동맥경화, 심장 질환, 자가면역 질환, 감염성 질환, 알러지, 신장 질환, 간 질환, 암, 비만 또는 당뇨를 포함한 비정상적 아디포넥틴 수준과 연관된 질환의 치료에 유용하게 사용될 수 있다. 3 3