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1. WO2020142102 - CONOTOXIN PEPTIDE ANALOGS AND USES FOR THE TREATMENT OF PAIN AND INFLAMMATORY CONDITIONS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2019/012307 14520-002-228
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
04 January 2019
Applicant
KINETA CHRONIC PAIN, LLC
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1A    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07K 14/435 (2006.01)i; A61K 38/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C07K; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, CHEM ABS Data, EMBASE

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2016073949 A1 (KINETA THREE LLP [US]) 12 May 2016 (2016-05-12)
1-25,28-58,61-81,84-164
cited in the application
the whole document
page 17; figure 5
(2)
X
ALESSANDRO GORI ET AL, "Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION,Vol. 54, No. 4, 04 December 2014 (2014-12-04), page 1361-1364,
XP055454027
1-25,28-58,61-81,84-164
the whole document
page 1362
(3)
X
WO 2009126292 A2 (AILERON THERAPEUTICS INC [US]; NASH HUW M [US] ET AL.) 15 October 2009 (2009-10-15)
1-25,28-58,61-81,84-164
page 19
(4)
X
KAI HOLLAND-NELL ET AL, "Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION,Vol. 50, No. 22, 23 May 2011 (2011-05-23), page 5204-5206,
XP055454226
1-25,28-58,61-81,84-164
figure 1
(5)
X
RENATA KOWALCZYK ET AL, "Synthesis and evaluation of disulfide bond mimetics of amylin-(1-8) as agents to treat osteoporosis", BIOORGANIC & MEDICINAL CHEMISTRY,Vol. 20, No. 8, 01 April 2012 (2012-04-01), page 2661-2668,
XP055201777
1-25,28-58,61-81,84-164
Scheme 3
(6)
X
US 2012220539 A1 (MCINTOSH J MICHAEL [US] ET AL) 30 August 2012 (2012-08-30)
1-25,28-58,61-81,84-164
cited in the application
figure 1
(7)
X
WO 2008011006 A2 (UNIV UTAH RES FOUND [US]; MCINTOSH J MICHAEL [US] ET AL.) 24 January 2008 (2008-01-24)
1-25,28-58,61-81,84-164
cited in the application
table 2
(8)
X
HAYLIE K. ROMERO ET AL, "Inhibition of [alpha]9[alpha]10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS),Vol. 114, No. 10, 21 February 2017 (2017-02-21), page E1825-E1832,
XP055621163
1-25,28-58,61-81,84-164
tables 1-2
(9)
A
PASUT GIANFRANCO ET AL, "State of the art in PEGylation: The great versatility achieved after forty years of research", JOURNAL OF CONTROLLED RELEASE,Vol. 161, No. 2, 07 November 2011 (2011-11-07), page 461-472,
XP028927182
1-164
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2016073949 A1
12 May 2016
AU 2015342767 A1
CA 2966865 A1
CN 107249616 A
EP 3215172 A1
JP 2018500385 A
KR 20170083574 A
TW 201629085 A
US 2018362599 A1
WO 2016073949 A1
15 June 2017
12 May 2016
13 October 2017
13 September 2017
11 January 2018
18 July 2017
16 August 2016
20 December 2018
12 May 2016
WO 2009126292 A2
15 October 2009
EP 2310407 A2
US 2009326192 A1
US 2013023646 A1
US 2014323701 A1
US 2016108089 A1
US 2017298099 A1
WO 2009126292 A2
20 April 2011
31 December 2009
24 January 2013
30 October 2014
21 April 2016
19 October 2017
15 October 2009
US 2012220539 A1
30 August 2012
NONE
WO 2008011006 A2
24 January 2008
AU 2007275764 A1
CA 2657532 A1
EP 2051726 A2
JP 5558817 B2
JP 5953338 B2
JP 2009545526 A
JP 2014210784 A
US 2009203616 A1
WO 2008011006 A2
24 January 2008
24 January 2008
29 April 2009
23 July 2014
20 July 2016
24 December 2009
13 November 2014
13 August 2009
24 January 2008
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
17 September 2019
Date of mailing of the international search report:
24 September 2019
Authorized officer:
Cervigni, S
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