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1. (WO2016123574) CRYSTALLINE FORMS OF C21H22CI2N4O2
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2016/123574    International Application No.:    PCT/US2016/015829
Publication Date: 04.08.2016 International Filing Date: 29.01.2016
IPC:
C07D 401/04 (2006.01)
Applicants: BIOMED VALLEY DISCOVERIES, INC. [US/US]; 4520 Main Street, 16th Fl. Kansas City, Missouri 64111 (US).
VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 50 Northern Avenue Boston, Massachusetts 02210 (US)
Inventors: DECRESCENZO, Gary; (US).
WELSCH, Dean; (US).
VLAHOVA, Petinka I.; (US).
BOERRIGTER, Stephan X.M.; (US).
ARONOV, Alexander; (US).
KESHAVARZ-SHOKRI, Ali; (US).
SCANGAS, Alexander N.; (US).
STAVROPOULOS, Kathy; (US).
LITTLER, Benjamin; (US).
KADIYALA, Irina Nikolaevna; (US).
ALARGOVA, Rossitza Gueorguieva; (US)
Agent: HOOPER, Kevin C.; (US)
Priority Data:
62/110,449 30.01.2015 US
Title (EN) CRYSTALLINE FORMS OF C21H22CI2N4O2
(FR) FORMES CRISTALLINES DE C21H22CI2N4O2
Abstract: front page image
(EN)The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.
(FR)La présente invention concerne des formes cristallines d'un composé de la formule (I). L'invention concerne également des compositions pharmaceutiques qui comprennent les formes cristallines décrites, des procédés d'utilisation desdites formes cristallines et des compositions pharmaceutiques pour le traitement du cancer. Il a été découvert que des formes cristallines de [1-(3-chlorophényl)-2-hydroxyéthyl]amide d'acide 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylique peuvent être préparées, celles-ci présentant de propriétés améliorées, par exemple une stabilité étonnamment améliorée et des caractéristiques améliorées de solubilité. Ainsi, la présente invention décrit du [1-(3-chlorophényl)-2-hydroxyéthyl]amide d'acide 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylique cristallin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)