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1. WO2016138458 - CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND

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CRYSTALLINE FORMS OF A PYRROLOPYRIDINE COMPOUND

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit under 35 USC § 119(e) of U.S. Provisional Application No. 62/121,396 filed on 26 February 2015, which is incorporated by reference in its entirety for all purposes.

FIELD OF THE INVENTION

Disclosed herein are crystalline forms of a pyrrolopyridine compound, and salts solvates, and hydrates thereof, with therapeutic activity, against diseases such as cancer, and processes for making the same.

BACKGROUND OF INVENTION

CHK1 is a serine/threonine kinase that regulates cell-cycle progression and is a main factor in DNA-damage response within a cell. CHK1 inhibitors have been shown to sensitize tumor cells to a variety of genotoxic agents, such as chemotherapy and radiation. U.S. Pat. No. 8,178,131 discusses a number of inhibitors of CHK1, including the compound (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (Compound 1), which is being investigated in clinical trials for the treatment of various cancers.


Compound 1

What is needed are forms of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide and its salts, solvates, and hydrates that have improved pharmaceutical properties.

SUMMARY OF INVENTION

One aspect includes crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes use of a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b] pyridin-3 -yl)cyclopropanecarboxamide , and pharmaceutically acceptable salts, solvates, and hydrates thereof, or pharmaceutical formulation thereof in therapy.

Another aspect includes a method of treating a cancer comprising administering a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, or pharmaceutical formulation thereof to a patient in need thereof.

One aspect includes crystalline forms of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 -yl)cyclopropanecarboxamide or hydrates thereof, pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes use of a crystalline form of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, or pharmaceutical formulation thereof in therapy.

Another aspect includes a method of treating a cancer comprising administering a crystalline form of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3 -aminopiperidin- 1-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, or pharmaceutical formulation thereof to a patient in need thereof.

DESCRIPTION OF FIGURES

Figure 1 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt.

Figure 2 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

ethanedisulfonic acid hydrate.

Figure 3 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid hydrate.

Figure 4 shows Xray physical characterization of a crystalline form (Form A) of the non-solvated free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide .

Figure 5 shows differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) of a crystalline form (Form A) of the non-solvated free base of (i?)-N-(4-(3 -aminopiperidin- 1-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide.

Figure 6 shows Xray physical characterization of a crystalline form (Form B) of the non-solvated free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide .

Figure 7 shows DSC of a crystalline form (Form B) of the non-solvated free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide.

Figure 8 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base cyclopropyl methyl ether solvate.

Figure 9 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base cyclopropyl methyl ether solvate.

Figure 10 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1,2-dichloroethane solvate.

Figure 11 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1,2-dichloroethane solvate.

Figure 12 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 2-methyltetrahydrofuran solvate.

Figure 13 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 2-methyltetrahydrofuran solvate.

Figure 14 shows the crystal structure of the asymmetric unit of the 2-methyltetrahydrofuran solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, as determined by single crystal X-ray diffraction (SCXRD).

Figure 15 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1-pentanol solvate.

Figure 16 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1-pentanol solvate.

Figure 17 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base pyridine solvate.

Figure 18 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base pyridine solvate.

Figure 19 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1,4-dioxane solvate.

Figure 20 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1,4-dioxane solvate.

Figure 21 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 2-butanol solvate.

Figure 22 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 2-butanol solvate.

Figure 23 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base anisole solvate.

Figure 24 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base anisole solvate.

Figure 25 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base 1-propanol solvate.

Figure 26 shows the crystal structure of the asymmetric unit of the bis-ethanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, as determined by SCXRD.

Figure 27 shows an X-ray powder diffraction (XRPD) pattern of a crystalline form of (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide free base bis-ethanol solvate calculated from the SCXRD data at 100 K.

Figure 28 shows the crystal structure of the asymmetric unit of the bis-methanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide along the crystallographic b axis, as determined by SCXRD.

Figure 29 shows an XRPD pattern of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base bis-methanol solvate calculated from the SCXRD data at 100 K.

Figure 30 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base methyl fert-butyl ether solvate.

Figure 31 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base methyl tert-butyl ether solvate.

Figure 32 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base toluene solvate.

Figure 33 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base toluene solvate.

Figure 34 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base butyronitrile solvate.

Figure 35 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base butyronitrile solvate.

Figure 36 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methane sulfonic acid salt hydrate.

Figure 37 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate.

Figure 38 shows TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate.

Figure 39 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate .

Figure 40 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di -ethane sulfonic acid salt hydrate.

Figure 41 shows TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di -ethanesulfonic acid salt hydrate.

Figure 42 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt.

Figure 43 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt.

Figure 44 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt.

Figure 45 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt.

Figure 46 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzene sulfonic acid salt.

Figure 47 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluene sulfonic acid salt.

Figure 48 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt.

Figure 49 shows Xray physical characterization of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt anhydrate.

Figure 50 shows DSC of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di -ethane sulfonic acid salt anhydrate.

Figure 51 shows TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di -ethane sulfonic acid salt anhydrate.

Figure 52 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt.

Figure 53 shows DSC and TGA of a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid hydrate.

Figure 54 shows the oral absorption of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base Form A and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt in PiC formulations, versus (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base in solution, in a preclinical pharmacokinetic study conducted in canines.

DETAILED DESCRIPTION OF INVENTION

The term "a" as used herein means one or more.

Reference to "about" a value or parameter herein includes (and describes) embodiments that are directed to that value or parameter per se and in one embodiment plus or minus 20% of the given value. For example, description referring to "about X" includes description of "X".

A "hydrate" refers to an association or complex of one or more water molecules and a compound of the invention.

Compounds of the present invention, unless otherwise indicated, include compounds that differ only in the presence of one or more isotopically enriched atoms. For example, compounds of the present invention, wherein one or more hydrogen atoms are replaced by deuterium or tritium, or one or more carbon atoms are replaced by a 1 C or 14C carbon atom, or one or more nitrogen atoms are replaced by a 15N nitrogen atom, or one or more sulfur atoms are replaced by a 33S, 34S or 36S sulfur atom, or one or more oxygen atoms are replaced by a 170 or 180 oxygen atom are within the scope of this invention.

It has been unexpectedly discovered that isolating (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, from particular solvents produces different physical forms of the compound, and that the different forms have different pharmaceutical properties. It has been found that certain forms have improved properties useful for formulating the compound into stable drug forms for treating diseases such as cancer.

Therefore, one aspect includes crystalline forms of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes crystalline form of an acetic acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, pharmaceutical

compositions, formulations and a process of manufacturing thereof.

Another aspect includes crystalline form of an ethanedisulfonic acid salt of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes crystalline form of a fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes a tablet formulation, comprising a crystalline form of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof and a process of manufacturing thereof.

Another aspect includes crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-

aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutically acceptable solvates and hydrates thereof; and pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-pentanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide pyridine solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,4-dioxane solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-butanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide anisole solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-ethanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-methanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert-butyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di- ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (R) -N-(4 -(3 -aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutical compositions, formulations and a process of manufacturing thereof.

Another aspect includes a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; and pharmaceutical compositions, formulations and a process of manufacturing thereof. In some embodiments, the crystalline form is Form A. In some embodiments, the crystalline form is Form B.

Another aspect includes a composition comprising a crystalline form of a compound selected from : (R) -N-(4 -(3 -aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, and a solvent selected from: cyclopropyl methyl ether, 1-pentanol, 2-butanol, anisole, 1-propanol, ethanol, methanol, and methyl fert-butyl ether.

Another aspect includes a tablet formulation, comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono -ethane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-toluene sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutically acceptable solvates and hydrates thereof; and a process of manufacturing thereof.

Another aspect includes a tablet formulation, comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate; (i?)-N-(4-(3 -aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate; (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate ; (R) -N-(4 -(3 -aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b]pyridin-3-yl)cyclopropanecarboxamide 1 -pentanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide pyridine solvate; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,4-dioxane solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-butanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide anisole solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-ethanol solvate ; (i?)-N-(4-(3 -aminopiperidin- 1 -yl) -5 -bromo- 1 H-pyrrolo [2 ,3 -b] pyridin-3 -yl)cyclopropanecarboxamide bis-methanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert-butyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b] pyridin-3 -yl)cyclopropanecarboxamide mono -ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-

aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and a process of manufacturing thereof.

Another aspect includes a tablet formulation, comprising a crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; and a process of manufacturing thereof. In some embodiments, the crystalline form is Form A. In some embodiments, the crystalline form is Form B.

METHODS OF TREATMENT WITH CRYSTALLINE FORM OF THE PRESENT INVENTION

The compounds described herein can be used as therapeutic agents for treating diseases.

In one embodiment, compounds of the present invention can be used for the treatment of hyperproliferative disorders, including cancers of the following categories: (1) Cardiac: sarcoma (angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarcoma), myxoma, rhabdomyoma, fibroma, lipoma and teratoma; (2) Lung: bronchogenic carcinoma (squamous cell, undifferentiated small cell, undifferentiated large cell, adenocarcinoma), alveolar (bronchiolar) carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hamartoma, mesothelioma, non-small cell lung, small cell lung;

(3) Gastrointestinal: esophagus (squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, lymphoma), stomach (carcinoma, lymphoma, leiomyosarcoma), pancreas (ductal adenocarcinoma, insulinoma, glucagonoma, gastrinoma, carcinoid tumors, vipoma), small bowel (adenocarcinoma, lymphoma, carcinoid tumors, Karposi's sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, fibroma), large bowel (adenocarcinoma, tubular adenoma, villous adenoma, hamartoma, leiomyoma);

(4) Genitourinary tract: kidney (adenocarcinoma, Wilm's tumor [nephroblastoma], lymphoma, leukemia), bladder and urethra (squamous cell carcinoma, transitional cell carcinoma,

adenocarcinoma), prostate (adenocarcinoma, sarcoma), testis (seminoma, teratoma, embryonal carcinoma, teratocarcinoma, choriocarcinoma, sarcoma, interstitial cell carcinoma, fibroma, fibroadenoma, adenomatoid tumors, lipoma); (5) Liver: hepatoma (hepatocellular carcinoma), cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, hemangioma; (6) Bone: osteogenic sarcoma (osteosarcoma), fibrosarcoma, malignant fibrous histiocytoma, chondrosarcoma, Ewing's sarcoma, malignant lymphoma (reticulum cell sarcoma), multiple myeloma, malignant giant cell tumor chordoma, osteochronfroma (osteocartilaginous exostoses), benign chondroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumors; (7) Nervous system: skull (osteoma, hemangioma, granuloma, xanthoma, osteitis deformans), meninges (meningioma, meningiosarcoma, gliomatosis), brain (astrocytoma, medulloblastoma, glioma, ependymoma, germinoma [pinealoma], glioblastoma multiforme, oligodendroglioma, schwannoma, retinoblastoma, congenital tumors), spinal cord neurofibroma, meningioma, glioma, sarcoma); (8) Gynecological: uterus (endometrial carcinoma), cervix (cervical carcinoma, pre-tumor cervical dysplasia), ovaries (ovarian carcinoma [serous cystadenocarcinoma, mucinous cystadenocarcinoma, unclassified

carcinoma], granulosa-thecal cell tumors, Sertoli -Leydig cell tumors, dysgerminoma, malignant teratoma), vulva (squamous cell carcinoma, intraepithelial carcinoma, adenocarcinoma, fibrosarcoma, melanoma), vagina (clear cell carcinoma, squamous cell carcinoma, botryoid sarcoma (embryonal rhabdomyosarcoma), fallopian tubes (carcinoma); (9) Hematologic: blood (myeloid leukemia [acute and chronic], acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, myelodysplastic syndrome), Hodgkin's disease, non-Hodgkin's lymphoma [malignant lymphoma]; (10) Skin: advanced melanoma, malignant melanoma, basal cell carcinoma, squamous cell carcinoma, Karposi's sarcoma, moles dysplastic nevi, lipoma, angioma, dermatofibroma, keloids, psoriasis; (1 1) Adrenal glands: neuroblastoma; (12) Breast: metastatic breast; breast adenocarcinoma; ( 13) Colon; (14) Oral cavity; (15) Hairy cell leukemia; ( 16) Head and neck; ( 17) and others including refractory metastatic disease; Kaposi's sarcoma; Bannayan-Zonana syndrome; and Cowden disease or Lhermitte-Duclos disease, among other kinds of hyperproliferative disorders. In one example, the disease is triple negative breast cancer.

Accordingly, another aspect of this invention provides a method of treating diseases or medical conditions in a mammal, comprising administering to said mammal one or more crystalline forms of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof in an amount effective to treat or prevent said disorder.

Accordingly, another aspect of this invention provides a method of treating diseases or medical conditions in a mammal, comprising administering to said mammal one or more crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof; in an amount effective to treat or prevent said disorder.

Accordingly, another aspect of this invention provides a method of treating diseases or medical conditions in a mammal, comprising administering to said mammal one or more crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono -ethane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N- (4-(3-aminopiperidin-l -yl)-5-bromo-lH-p^ di-toluene sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutically acceptable solvates and hydrates thereof; in an amount effective to treat or prevent said disorder.

Accordingly, another aspect of this invention provides a method of treating diseases or medical conditions in a mammal, comprising administering to said mammal one or more crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate; (i?)-N-(4-(3 -aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate; (R)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1 -pentanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide pyridine solvate; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,4-dioxane solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-butanol solvate ; (i?)-N-(4-(3 -aminopiperidin- 1 -yl) -5 -bromo- 1 H-pyrrolo [2 ,3 -b] pyridin-3 -yl)cyclopropanecarboxamide anisole solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-ethanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-methanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert-butyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-

b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo[2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-HBr salt; in an amount effective to treat or prevent said disorder.

Accordingly, another aspect of this invention provides a method of treating diseases or medical conditions in a mammal, comprising administering to said mammal a crystalline form of (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; in an amount effective to treat or prevent said disorder. In some embodiments, the crystalline form is Form A. In some embodiments, the crystalline form is Form B.

The phrase "effective amount" means an amount of compound that, when administered to a mammal in need of such treatment, is sufficient to (i) attenuate, ameliorate, or eliminate one or more symptoms of the particular disease, condition, or disorder, or (iii) prevent or delay the onset of one or more symptoms of the particular disease, condition, or disorder described herein. In the case of cancer, an effective amount of the drug may reduce the number of cancer cells; reduce the tumor size; inhibit (i.e., slow to some extent and preferably stop) cancer cell infiltration into peripheral organs; inhibit (i.e., slow to some extent and preferably stop) tumor metastasis; inhibit, to some extent, tumor growth; and/or relieve to some extent one or more of the symptoms associated with the cancer. To the extent the drug may prevent growth and/or kill existing cancer cells, it may be cytostatic and/or cytotoxic. For cancer therapy, efficacy can be measured, for example, by assessing the time to disease progression (TTP) and/or determining the response rate (RR).

The amount of a compound of the present invention that will correspond to such an effective amount will vary depending upon factors such as the particular compound, disease condition and its severity, the identity (e.g., weight) of the mammal in need of treatment, but can nevertheless be routinely determined by one skilled in the art.

The terms "treat" and "treatment" refer to therapeutic treatment, wherein the object is to prevent or slow down (lessen) an undesired physiological change or disorder. For purposes of this invention, beneficial or desired clinical results include, but are not limited to, alleviation of symptoms, diminishment of extent of disease, stabilized (i.e., not worsening) state of disease, delay or slowing of disease progression, amelioration or palliation of the disease state, and remission (whether partial or total), whether detectable or undetectable. "Treatment" can also mean prolonging survival as compared to expected survival if not receiving treatment. Those in need of treatment include those already with the condition or disorder as having been diagnosed as having it by a licensed medical doctor.

As used herein, the term "mammal" refers to a warm-blooded animal that has or is at risk of developing a disease described herein and includes, but is not limited to, guinea pigs, dogs, cats, rats, mice, hamsters, and primates, including humans.

This invention also provides crystalline forms of the present invention for use in the treatment of CHK1 protein kinase-mediated conditions.

An additional aspect of the invention is the use of a crystalline form of the present invention in the preparation of a medicament for therapy, such as for the treatment or prevention of CHK1 protein kinase-mediated conditions.

One aspect of the present invention relates to a method of treating a disease or disorder modulated by CHK1, comprising administering a crystalline form of the present invention, or pharmaceutical formulation thereof, to a patient in need thereof. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma.

Another aspect of the present invention relates to a use of a crystalline form of the present invention, in the manufacture of a medicament for treating a disease or disorder modulated by CHK1. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma.

Another aspect of the present invention relates to a crystalline form of the present invention, or pharmaceutical formulation thereof, for use in a method of treatment of the human or animal body by therapy.

Another aspect of the present invention relates to a crystalline form of the present invention, or pharmaceutical formulation thereof, for use in a method of treating a disease or disorder modulated by CHK1. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma.

COMBINATION THERAPY

The compounds of the present invention can be used in combination with one or more additional drugs such as described below. The dose of the second drug can be appropriately selected based on a clinically employed dose. The proportion of the compound of the present invention and the second drug can be appropriately determined according to the administration subject, the

administration route, the target disease, the clinical condition, the combination, and other factors. In cases where the administration subject is a human, for instance, the second drug may be used in an amount of 0.01 to 100 parts by weight per part by weight of the compound of the present invention.

The second compound of the pharmaceutical combination formulation or dosing regimen preferably has complementary activities to the compound of this invention such that they do not adversely affect each other. Such drugs are suitably present in combination in amounts that are effective for the purpose intended. Accordingly, another aspect of the present invention provides a composition comprising a compound of this invention in combination with a second drug, such as described herein.

A compound of this invention and the additional pharmaceutically active drug(s) may be administered together in a unitary pharmaceutical composition or separately and, when administered separately this may occur simultaneously or sequentially in any order. Such sequential administration may be close in time or remote in time. The amounts of the compound of this invention and the second drug(s) and the relative timings of administration will be selected in order to achieve the desired combined therapeutic effect.

The combination therapy may provide "synergy" and prove "synergistic", i.e., the effect achieved when the active ingredients used together is greater than the sum of the effects that results from using the compounds separately. A synergistic effect may be attained when the active ingredients are: (1) co-formulated and administered or delivered simultaneously in a combined, unit dosage formulation; (2) delivered by alternation or in parallel as separate formulations; or (3) by some other regimen. When delivered in alternation therapy, a synergistic effect may be attained when the compounds are administered or delivered sequentially, e.g., by different injections in separate syringes. In general, during alternation therapy, an effective dosage of each active ingredient is administered sequentially, i.e., serially, whereas in combination therapy, effective dosages of two or more active ingredients are administered together.

A "chemotherapeutic agent" is a chemical compound useful in the treatment of cancer, regardless of mechanism of action. Chemotherapeutic agents include compounds used in "targeted therapy" and conventional chemotherapy.

Examples of chemotherapeutic agents include gemcitabine, Erlotinib (TARCEVA®, Genentech/OSI Pharm.), Bortezomib (VELCADE®, Millennium Pharm.), Fulvestrant

(FASLODEX®, AstraZeneca), Sutent (SU11248, Pfizer), Letrozole (FEMARA®, Novartis), Imatinib mesylate (GLEEVEC®, Novartis), PTK787/ZK 222584 (Novartis), Oxaliplatin (Eloxatin®, Sanofi), 5-FU (5-fluorouracil), Leucovorin, Rapamycin (Sirolimus, RAPAMUNE®, Wyeth), Lapatinib (TYKERB®, GSK572016, Glaxo Smith Kline), Lonafarnib (SCH 66336), Sorafenib (BAY43-9006, Bayer Labs), Irinotecan (CAMPTOSAR®, Pfizer) and Gefitinib (IRESSA®, AstraZeneca), AG1478, AG1571 (SU 5271; Sugen), alkylating agents such as thiotepa and CYTOXAN® cyclosphosphamide; alkyl sulfonates such as busulfan, improsulfan and piposulfan; aziridines such as benzodopa, carboquone, meturedopa, and uredopa; ethylenimines and methylamelamines including altretamine,

triethylenemelamine, triethylenephosphoramide, triethylenethiophosphoramide and

trimethylomelamine; acetogenins (especially bullatacin and bullatacinone); a camptothecin (including the synthetic analog topotecan); bryostatin; callystatin; CC-1065 (including its adozelesin, carzelesin and bizelesin synthetic analogs); cryptophycins (particularly cryptophycin 1 and cryptophycin 8); dolastatin; duocarmycin (including the synthetic analogs, KW-2189 and CB 1-TM1); eleutherobin; pancratistatin; a sarcodictyin; spongistatin; nitrogen mustards such as chlorambucil, chlornaphazine, chlorophosphamide, estramustine, ifosfamide, mechlorethamine, mechlorethamine oxide

hydrochloride, melphalan, novembichin, phenesterine, prednimustine, trofosfamide, uracil mustard; nitrosureas such as carmustine, chlorozotocin, fotemustine, lomustine, nimustine, and ranimnustine; antibiotics such as the enediyne antibiotics (e.g., calicheamicin, especially calicheamicin gammall and calicheamicin omegall (Angew Chem. Intl. Ed. Engl. (1994) 33: 183-186); dynemicin, including dynemicin A; bisphosphonates, such as clodronate; an esperamicin; as well as neocarzinostatin chromophore and related chromoprotein enediyne antibiotic chromophores), aclacinomysins, actinomycin, authramycin, azaserine, bleomycins, cactinomycin, carabicin, carminomycin, carzinophilin, chromomycins, dactinomycin, daunorubicin, detorubicin, 6-diazo-5-oxo-L-norleucine, ADRIAMYCIN® (doxorubicin), morpholino-doxorubicin, cyanomorpholino-doxorubicin, 2-pyrrolino-doxorubicin, deoxydoxorubicin, epirubicin, esorubicin, idarubicin, marcellomycin, mitomycins such as mitomycin C, mycophenolic acid, nogalamycin, olivomycins, peplomycin, porfiromycin, puromycin, quelamycin, rodorubicin, streptonigrin, streptozocin, tubercidin, ubenimex, zinostatin, zorubicin; anti-metabolites such as methotrexate and 5-fluorouracil (5-FU); folic acid analogs such as denopterin, methotrexate, pteropterin, trimetrexate; purine analogs such as fludarabine, 6-mercaptopurine, thiamiprine, thioguanine; pyrimidine analogs such as ancitabine, azacitidine, 6-azauridine, carmofur, cytarabine, dideoxyuridine, doxifluridine, enocitabine, floxuridine; androgens such as calusterone, dromostanolone propionate, epitiostanol, mepitiostane, testolactone; anti-adrenals such as aminoglutethimide, mitotane, trilostane; folic acid replenisher such as frolinic acid; aceglatone; aldophosphamide glycoside; aminolevulinic acid; eniluracil; amsacrine; bestrabucil; bisantrene; edatraxate; defofamine; demecolcine; diaziquone; eflornithine; elliptinium acetate; an epothilone; etoglucid; gallium nitrate; hydroxyurea; lentinan; lonidainine; maytansinoids such as maytansine and ansamitocins; mitoguazone; mitoxantrone; mopidanmol; nitraerine;

pentostatin; phenamet; pirarubicin; losoxantrone; podophyllinic acid; 2-ethylhydrazide; procarbazine; PSK® polysaccharide complex (JHS Natural Products, Eugene, OR); razoxane; rhizoxin; sizofiran; spirogermanium; tenuazonic acid; triaziquone; 2,2',2"-trichlorotriethylamine; trichothecenes (especially T-2 toxin, verracurin A, roridin A and anguidine); urethan; vindesine; dacarbazine;

mannomustine; mitobronitol; mitolactol; pipobroman; gacytosine; arabinoside ("Ara-C");

cyclophosphamide; thiotepa; taxoids, e.g., TAXOL® (paclitaxel; Bristol-Myers Squibb Oncology,

Princeton, N.J.), ABRAXANE™ (Cremophor-free), albumin-engineered nanoparticle formulations of paclitaxel (American Pharmaceutical Partners, Schaumberg, Illinois), and TAXOTERE® (doxetaxel;

Rhone-Poulenc Rorer, Antony, France); chlorambucil; GEMZAR® (gemcitabine); 6-thioguanine; mercaptopurine; methotrexate; platinum analogs such as cisplatin and carboplatin; vinblastine;

etoposide (VP-16); ifosfamide; mitoxantrone; vincristine; NAVELBINE® (vinorelbine); novantrone; teniposide; edatrexate; daunomycin; aminopterin; capecitabine (XELODA®); ibandronate; CPT-11; topoisomerase inhibitor RFS 2000; difluoromethylornithine (DMFO); retinoids such as retinoic acid; and pharmaceutically acceptable salts, acids and derivatives of any of the above.

Also included in the definition of "chemotherapeutic agent" are: (i) anti -hormonal agents that act to regulate or inhibit hormone action on tumors such as anti -estrogens and selective estrogen receptor modulators (SERMs), including, for example, tamoxifen (including NOLVADEX®;

tamoxifen citrate), raloxifene, droloxifene, 4-hydroxytamoxifen, trioxifene, keoxifene, LY117018, onapristone, and FARESTON® (toremifine citrate); (ii) aromatase inhibitors that inhibit the enzyme aromatase, which regulates estrogen production in the adrenal glands, such as, for example, 4(5)-imidazoles, aminoglutethimide, MEGASE® (megestrol acetate), AROMASIN® (exemestane; Pfizer), formestanie, fadrozole, RIVISOR® (vorozole), FEMARA® (letrozole; Novartis), and ARIMIDEX® (anastrozole; AstraZeneca); (iii) anti -androgens such as flutamide, nilutamide, bicalutamide, leuprolide, and goserelin; as well as troxacitabine (a 1,3-dioxolane nucleoside cytosine analog); (iv) protein kinase inhibitors; (v) lipid kinase inhibitors; (vi) antisense oligonucleotides, particularly those which inhibit expression of genes in signaling pathways implicated in aberrant cell proliferation, such as, for example, PKC -alpha, Ralf and H-Ras; (vii) ribozymes such as VEGF expression inhibitors (e.g., ANGIOZYME®) and HER2 expression inhibitors; (viii) vaccines such as gene therapy vaccines, for example, ALLOVECTIN®, LEUVECTIN®, and VAXID®; PROLEUKIN® rIL-2; a topoisomerase 1 inhibitor such as LURTOTECAN®; ABARELIX® rmRH; (ix) anti -angiogenic agents such as bevacizumab (AVASTIN®, Genentech); and (x) pharmaceutically acceptable salts, acids and derivatives of any of the above.

Also included in the definition of "chemotherapeutic agent" are therapeutic antibodies such as alemtuzumab (Campath), bevacizumab (AVASTIN®, Genentech); cetuximab (ERBITUX®, Imclone); panitumumab (VECTIBIX®, Amgen), rituximab (RITUXAN®, Genentech/Biogen Idee), pertuzumab (OMNITARG®, 2C4, Genentech), trastuzumab (HERCEPTIN®, Genentech), tositumomab (Bexxar, Corixia), and the antibody drug conjugate, gemtuzumab ozogamicin

(MYLOTARG® , Wyeth) .

Humanized monoclonal antibodies with therapeutic potential as chemotherapeutic agents in combination with the PI3K inhibitors of the invention include: alemtuzumab, apolizumab, aselizumab, atlizumab, bapineuzumab, bevacizumab, bivatuzumab mertansine, cantuzumab mertansine, cedelizumab, certolizumab pegol, cidfusituzumab, cidtuzumab, daclizumab, eculizumab, efalizumab, epratuzumab, erlizumab, felvizumab, fontolizumab, gemtuzumab ozogamicin, inotuzumab ozogamicin, ipilimumab, labetuzumab, lintuzumab, matuzumab, mepolizumab, motavizumab, motovizumab, natalizumab, nimotuzumab, nolovizumab, numavizumab, ocrelizumab,

omalizumab, palivizumab, pascolizumab, pecfusituzumab, pectuzumab, pertuzumab, pexelizumab, ralivizumab, ranibizumab, reslivizumab, reslizumab, resyvizumab, rovelizumab, ruplizumab, sibrotuzumab, siplizumab, sontuzumab, tacatuzumab tetraxetan, tadocizumab, talizumab, tefibazumab, tocilizumab, toralizumab, trastuzumab, tucotuzumab celmoleukin, tucusituzumab, umavizumab, urtoxazumab, and visilizumab.

Accordingly one aspect of the present invention relates to a pharmaceutical formulation comprising a crystalline form of the present invention and a DNA damaging agent. In some embodiments, the DNA damaging agent is selected from: gemcitabine, irinotecan, temozolomide, capecitabine, camptothecin, cisplatin, ara-C, and 5-FU. In some embodiments, the formulation further comprises an excipient. In some embodiments, the formulation is a tablet for oral delivery.

Another aspect of the present invention relates to a method of treating a disease or disorder modulated by CHKl, comprising administering a crystalline form of the present invention, or pharmaceutical formulation thereof, to a patient in need thereof, wherein a DNA damaging agent is also administered. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma. In some embodiments, the DNA damaging agent is selected from: gemcitabine, irinotecan, temozolomide, capecitabine, camptothecin, cisplatin, ara-C, and 5-FU.

Another aspect of the present invention relates to a use of a crystalline form of the present invention, in the manufacture of a medicament for treating a disease or disorder modulated by CHKl, wherein the medicament further comprises a DNA damaging agent. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma. In some embodiments, the DNA damaging agent is selected from: gemcitabine, irinotecan,

temozolomide, capecitabine, camptothecin, cisplatin, ara-C, and 5-FU.

Another aspect of the present invention relates to a crystalline form of the present invention, or pharmaceutical formulation thereof, for use in a method of treating a disease or disorder modulated by CHKl, in combination with a DNA damaging agent. In some embodiments, the disease is cancer. In some embodiments, the cancer is selected from: leukemia, pancreatic cancer, breast cancer, colon cancer, rectal cancer, colorectal cancer, a refractory solid tumor, and lymphoma. In some

embodiments, the DNA damaging agent is selected from: gemcitabine, irinotecan, temozolomide, capecitabine, camptothecin, cisplatin, ara-C, and 5-FU.

ROUTES OF ADMINISTRATION

The compounds of the invention may be administered by any route appropriate to the condition to be treated. Suitable routes include oral, parenteral (including subcutaneous,

intramuscular, intravenous, intraarterial, intradermal, intrathecal and epidural), transdermal, rectal, nasal, topical (including buccal and sublingual), vaginal, intraperitoneal, intrapulmonary and intranasal. It will be appreciated that the preferred route may vary with for example the condition of the recipient. Where the compound is administered orally, it may be formulated as a pill, capsule, tablet, etc. with a pharmaceutically acceptable carrier or excipient. Where the compound is administered parenterally, it may be formulated with a pharmaceutically acceptable parenteral vehicle and in a unit dosage injectable form, as detailed below.

PHARMACEUTICAL FORMULATIONS

In order to use a compound of this invention for the therapeutic treatment (including prophylactic treatment) of mammals including humans, it is normally formulated in accordance with standard pharmaceutical practice as a pharmaceutical composition. According to this aspect of the invention there is provided a pharmaceutical composition that comprises a compound of this invention. In certain embodiments, the pharmaceutical composition comprises a crystalline form of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof in association with a pharmaceutically acceptable diluent or carrier.

In certain embodiments, the pharmaceutical composition comprises a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof; in association with a pharmaceutically acceptable diluent or carrier.

In certain embodiments, the pharmaceutical composition comprises a composition comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, and a solvent selected from: cyclopropyl methyl ether, 1-pentanol, 2-butanol, anisole, 1-propanol, ethanol, methanol, and methyl fert-butyl ether; in association with a

pharmaceutically acceptable diluent or carrier.

In certain embodiments, the pharmaceutical composition comprises a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide mono -ethane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluene sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutically acceptable solvates and hydrates thereof; in association with a pharmaceutically acceptable diluent or carrier.

In certain embodiments, the pharmaceutical composition comprises a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1 -pentanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide pyridine solvate; (i?)-N -(4-(3 -aminopiperidin- 1 -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,4-dioxane solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-butanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide anisole solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-ethanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-methanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert-butyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-

ethanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2, 3 -b] pyridin-3 -yl)cyclopropanecarboxamide mono -ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; in association with a pharmaceutically acceptable diluent or carrier.

In certain embodiments, the pharmaceutical composition comprises a crystalline form of (R)- N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; in association with a pharmaceutically acceptable diluent or carrier. In some embodiments, the crystalline form is Form A. In some embodiments, the crystalline form is Form B.

The pharmaceutical compositions of the invention are formulated, dosed and administered in a fashion, i.e., amounts, concentrations, schedules, course, vehicles and route of administration, consistent with good medical practice. Factors for consideration in this context include the particular disorder being treated, the particular mammal being treated, the clinical condition of the individual patient, the cause of the disorder, the site of delivery of the agent, the method of administration, the scheduling of administration, and other factors known to medical practitioners. The therapeutically effective amount of the compound to be administered will be governed by such considerations, and is the minimum amount necessary to prevent, ameliorate, or treat the disorder. The compound of the present invention is typically formulated into pharmaceutical dosage forms to provide an easily controllable dosage of the drug and to enable patient compliance with the prescribed regimen.

The composition for use herein is preferably sterile. In particular, formulations to be used for in vivo administration must be sterile. Such sterilization is readily accomplished, for example, by filtration through sterile filtration membranes. The compound ordinarily can be stored as a solid composition, a lyophilized formulation or as an aqueous solution.

Pharmaceutical formulations of the compounds of the present invention may be prepared for various routes and types of administration. For example, a compound of this invention having the desired degree of purity may optionally be mixed with pharmaceutically acceptable diluents, carriers, excipients or stabilizers (Remington's Pharmaceutical Sciences ( 1980) 16th edition, Osol, A. Ed.), in the form of a lyophilized formulation, a milled powder, or an aqueous solution. Formulation may be conducted by mixing at ambient temperature at the appropriate pH, and at the desired degree of purity, with physiologically acceptable carriers, i.e., carriers that are non-toxic to recipients at the dosages and concentrations employed. The pH of the formulation depends mainly on the particular use and the concentration of compound, but may range from about 3 to about 8. The formulations may be prepared using conventional dissolution and mixing procedures.

The particular carrier, diluent or excipient used will depend upon the means and purpose for which the compound of the present invention is being applied. Solvents are generally selected based on solvents recognized by persons skilled in the art as safe (GRAS) to be administered to a mammal. In general, safe solvents are non-toxic aqueous solvents such as water and other non-toxic solvents that are soluble or miscible in water. Suitable aqueous solvents include water, ethanol, propylene glycol, polyethylene glycols (e.g., PEG 400, PEG 300), etc. and mixtures thereof. Acceptable diluents, carriers, excipients and stabilizers are nontoxic to recipients at the dosages and

concentrations employed, and include buffers such as phosphate, citrate and other organic acids; antioxidants including ascorbic acid and methionine; preservatives (such as octadecyldimethylbenzyl ammonium chloride; hexamethonium chloride; benzalkonium chloride, benzethonium chloride;

phenol, butyl or benzyl alcohol; alkyl parabens such as methyl or propyl paraben; catechol; resorcinol; cyclohexanol; 3-pentanol; and m-cresol); low molecular weight (less than about 10 residues) polypeptides; proteins, such as serum albumin, gelatin, or immunoglobulins; hydrophilic polymers such as polyvinylpyrrolidone; amino acids such as glycine, glutamine, asparagine, histidine, arginine, or lysine; monosaccharides, disaccharides and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugars such as sucrose, mannitol, trehalose or sorbitol; salt-forming counter-ions such as sodium; metal complexes (e.g., Zn-protein complexes); and/or non-ionic surfactants such as TWEEN™, PLURONICS™ or polyethylene glycol (PEG). The formulations may also include one or more stabilizing agents, surfactants, wetting agents, lubricating agents, emulsifiers, suspending agents, preservatives, antioxidants, opaquing agents, glidants, processing aids, colorants, sweeteners, perfuming agents, flavoring agents and other known additives to provide an elegant presentation of the drug (i.e., a compound of the present invention or pharmaceutical composition thereof) or aid in the manufacturing of the pharmaceutical product (i.e., medicament). The active pharmaceutical ingredients may also be entrapped in microcapsules prepared, for example, by coacervation techniques or by interfacial polymerization, for example, hydroxymethylcellulose or gelatin-microcapsules and poly-(methylmethacrylate) microcapsules, respectively, in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nanoparticles and nanocapsules) or in macroemulsions. Such techniques are disclosed in Remington's Pharmaceutical Sciences 16th edition, Osol, A. Ed. (1980).

Sustained-release preparations of compounds of this invention may be prepared. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing a crystalline form of the present invention, which matrices are in the form of shaped articles, e.g., films, or microcapsules. Examples of sustained-release matrices include polyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate), or poly(vinylalcohol)), polylactides (U.S. Patent No. 3,773,919), copolymers of L-glutamic acid and gamma-ethyl-L-glutamate, non-degradable ethylene-vinyl acetate, degradable lactic acid-glycolic acid copolymers such as the LUPRON DEPOT™ (injectable microspheres composed of lactic acid-glycolic acid copolymer and leuprolide acetate) and poly-D-(-)-3-hydroxybutyric acid.

The compositions of the invention may also be in a form suitable for oral use (for example as tablets, lozenges, hard or soft capsules, aqueous or oily suspensions, emulsions, dispersible powders or granules, syrups or elixirs), for topical use (for example as creams, ointments, gels, or aqueous or oily solutions or suspensions), for administration by inhalation (for example as a finely divided powder or a liquid aerosol), for administration by insufflation (for example as a finely divided powder).

Suitable pharmaceutically-acceptable excipients for a tablet formulation include, for example, inert diluents such as lactose, sodium carbonate, calcium phosphate or calcium carbonate, granulating and disintegrating agents such as corn starch or algenic acid; binding agents such as starch; lubricating agents such as magnesium stearate, stearic acid or talc; preservative agents such as ethyl or propyl p-hydroxybenzoate, and antioxidants, such as ascorbic acid. Tablet formulations may be uncoated or coated either to modify their disintegration and the subsequent absorption of the active ingredient within the gastrointestinal tract, or to improve their stability and/or appearance, in either case, using conventional coating agents and procedures well known in the art.

Compositions for oral use may be in the form of hard gelatin capsules in which the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or as soft gelatin capsules in which the active ingredient is mixed with water or an oil such as peanut oil, liquid paraffin, or olive oil.

Aqueous suspensions generally contain the active ingredient in finely powdered form together with one or more suspending agents, such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinyl-pyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents such as lecithin or condensation products of an alkylene oxide with fatty acids (for example polyoxethylene stearate), or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecaethyleneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives (such as ethyl or propyl p-hydroxybenzoate, anti -oxidants (such as ascorbic acid), coloring agents, flavoring agents, and/or sweetening agents (such as sucrose, saccharine or aspartame).

Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil (such as arachis oil, olive oil, sesame oil or coconut oil) or in a mineral oil (such as liquid paraffin). The oily suspensions may also contain a thickening agent such as beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set out above, and flavoring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an antioxidant such as ascorbic acid.

Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water generally contain the active ingredient together with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients such as sweetening, flavoring and coloring agents, may also be present.

The pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, such as olive oil or arachis oil, or a mineral oil, such as for example liquid paraffin or a mixture of any of these. Suitable emulsifying agents may be, for example, naturally-occurring gums such as gum acacia or gum tragacanth, naturally-occurring phosphatides such as soya bean, lecithin, esters or partial esters derived from fatty acids and hexitol anhydrides (for example sorbitan monooleate) and condensation products of the said partial esters with ethylene oxide such as polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening, flavoring and preservative agents.

Syrups and elixirs may be formulated with sweetening agents such as glycerol, propylene glycol, sorbitol, aspartame or sucrose, and may also contain a demulcent, preservative, flavoring and/or coloring agent.

The pharmaceutical composition (or formulation) for application may be packaged in a variety of ways depending upon the method used for administering the drug. For example, an article for distribution can include a container having deposited therein the pharmaceutical formulation in an appropriate form. Suitable containers are well known to those skilled in the art and include materials such as bottles (plastic and glass), sachets, ampoules, plastic bags, metal cylinders, and the like. The container may also include a tamper-proof assemblage to prevent indiscreet access to the contents of the package. In addition, the container has deposited thereon a label that describes the contents of the container. The label may also include appropriate warnings. The formulations may also be packaged in unit-dose or multi-dose containers, for example sealed ampoules and vials, and may be stored in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example water, for injection immediately prior to use. Extemporaneous injection solutions and suspensions are prepared from sterile powders, granules and tablets of the kind previously described. Preferred unit dosage formulations are those containing a daily dose or unit daily sub-dose, as herein above recited, or an appropriate fraction thereof, of the active ingredient.

The invention further provides veterinary compositions comprising at least one active ingredient as above defined together with a veterinary carrier therefore. Veterinary carriers are materials useful for the purpose of administering the composition and may be solid, liquid or gaseous materials which are otherwise inert or acceptable in the veterinary art and are compatible with the active ingredient. These veterinary compositions may be administered parenterally, orally or by any other desired route.

The amount of a compound of this invention that is combined with one or more excipients to produce a single dosage form will necessarily vary depending upon the subject treated, the severity of the disorder or condition, the rate of administration, the disposition of the compound and the discretion of the prescribing physician. In one embodiment, a suitable amount of a compound of this invention is administered to a mammal in need thereof. Administration in one embodiment occurs in an amount between about 0.001 mg/kg of body weight to about 60 mg/kg of body weight per day. In another embodiment, administration occurs in an amount between 0.5 mg/kg of body weight to about 40 mg/kg of body weight per day. In some instances, dosage levels below the lower limit of the aforesaid range may be more than adequate, while in other cases still larger doses may be employed without causing any harmful side effect, provided that such larger doses are first divided into several small doses for administration throughout the day. For further information on routes of administration and dosage regimes, see Chapter 25.3 in Volume 5 of Comprehensive Medicinal Chemistry (Corwin Hansen; Chairman of Editorial Board), Pergamon Press 1990, which is specifically incorporated herein by reference.

ARTICLES OF MANUFACTURE

In another embodiment of the invention, an article of manufacture, or "kit", containing materials useful for the treatment of the disorders described above is provided. In one embodiment, the kit comprises a container comprising a compound of this invention. Suitable containers include, for example, bottles, vials, syringes, blister pack, etc. The container may be formed from a variety of materials such as glass or plastic. The container may hold a compound of this invention or a formulation thereof which is effective for treating the condition and may have a sterile access port (for example, the container may be an intravenous solution bag or a vial having a stopper pierceable by a hypodermic injection needle).

The kit may further comprise a label or package insert on or associated with the container. The term "package insert" is used to refer to instructions customarily included in commercial packages of therapeutic products, that contain information about the indications, usage, dosage, administration, contraindications and/or warnings concerning the use of such therapeutic products. In one embodiment, the label or package inserts indicates that the composition comprising a compound of this invention can be used to treat a disorder such as cancer. The label or package insert may also indicate that the composition can be used to treat other disorders.

In certain embodiments, the kits are suitable for the delivery of solid oral forms of a compound of this invention, such as tablets or capsules. Such a kit preferably includes a number of unit dosages. Such kits can include a card having the dosages oriented in the order of their intended use. An example of such a kit is a "blister pack". Blister packs are well known in the packaging industry and are widely used for packaging pharmaceutical unit dosage forms. If desired, a memory aid can be provided, for example in the form of numbers, letters, or other markings or with a calendar insert, designating the days in the treatment schedule in which the dosages can be administered.

According to another embodiment, a kit may comprise (a) a first container with a compound of this invention contained therein; and (b) a second container with a second pharmaceutical formulation contained therein, wherein the second pharmaceutical formulation comprises a second compound useful for treating a disorder such as cancer. Alternatively, or additionally, the kit may further comprise a third container comprising a pharmaceutically-acceptable buffer, such as bacteriostatic water for injection (BWFI), phosphate-buffered saline, Ringer's solution and dextrose solution. It may further include other materials desirable from a commercial and user standpoint, including other buffers, diluents, filters, needles, and syringes.

The kit may further comprise directions for the administration of the compound of this invention and, if present, the second pharmaceutical formulation. For example, if the kit comprises a first composition comprising a compound of this invention and a second pharmaceutical formulation, the kit may further comprise directions for the simultaneous, sequential or separate administration of the first and second pharmaceutical compositions to a patient in need thereof.

In certain other embodiments wherein the kit comprises a composition of this invention and a second therapeutic agent, the kit may comprise a container for containing the separate compositions such as a divided bottle or a divided foil packet, however, the separate compositions may also be contained within a single, undivided container. In certain embodiments, the kit comprises directions for the administration of the separate components. The kit form is particularly advantageous when the separate components are preferably administered in different dosage forms (e.g., oral and parenteral), are administered at different dosage intervals, or when titration of the individual components of the combination is desired by the prescribing physician.

Accordingly, a further aspect of this invention provides a kit for treating a disorder, wherein said kit comprises a) a first pharmaceutical composition comprising a crystalline form of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof; and b) instructions for use.

Accordingly, a further aspect of this invention provides a kit for treating a disorder, wherein said kit comprises a) a first pharmaceutical composition comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof; and b) instructions for use.

Accordingly, a further aspect of this invention provides a kit for treating a disorder, wherein said kit comprises a) a first pharmaceutical composition comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methane sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono -ethane sulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-toluene sulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and pharmaceutically acceptable solvates and hydrates thereof; and b) instructions for use.

Accordingly, a further aspect of this invention provides a kit for treating a disorder, wherein said kit comprises a) a first pharmaceutical composition comprising a crystalline form of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide acetic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide ethanedisulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo[2,3-b]pyridin-3 -yl)cyclopropanecarboxamide; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1 -pentanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide pyridine solvate; (i?)-N-(4-(3 -aminopiperidin- 1-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,4-dioxane solvate; (i?)-N-(4- (3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-butanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide anisole solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-ethanol solvate ; (i?)-N-(4-(3 -aminopiperidin- 1 -yl) -5 -bromo- 1 H-pyrrolo [2 ,3 -b] pyridin-3 -yl)cyclopropanecarboxamide bis-methanol solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert-butyl ether solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-methanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-toluenesulfonic acid salt; (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-ethanesulfonic acid salt; (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide maleic acid salt; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide HBr salt methanol solvate; (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HCl salt; and (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-HBr salt; and b) instructions for use.

Accordingly, a further aspect of this invention provides a kit for treating a disorder, wherein said kit comprises a) a first pharmaceutical composition comprising a crystalline form of (i?)-N-(4-(3-aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b] pyridin-3 -yl)cyclopropanecarboxamide ; and b) instructions for use. In some embodiments, the crystalline form is Form A. In some embodiments, the crystalline form is Form B.

In certain embodiments, the kit further comprises (c) a second pharmaceutical composition, wherein the second pharmaceutical composition comprises a second compound suitable for treating the disease. In certain embodiments comprising a second pharmaceutical composition, the kit further comprises instructions for the simultaneous, sequential or separate administration of said first and second pharmaceutical compositions to a patient in need thereof. In certain embodiments, said first and second pharmaceutical compositions are contained in separate containers. In other embodiments, said first and second pharmaceutical compositions are contained in the same container.

Although the crystalline forms of an acetic acid, ethanedisulfonic acid or fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide or hydrates thereof, are primarily of value as therapeutic agents for use in mammals, they are also useful whenever it is required to control CHK1 protein kinases, tyrosine kinases, additional serine/threonine kinases, and/or dual specificity kinases. Thus, they are useful as pharmacological standards for use in the development of new biological tests and in the search for new

pharmacological agents and pharmaceutical forms thereof.

Although the crystalline forms of a compound selected from: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and pharmaceutically acceptable salts, solvates, and hydrates thereof, are primarily of value as therapeutic agents for use in mammals, they are also useful whenever it is required to control CHK1 protein kinases, tyrosine kinases, additional serine/threonine kinases, and/or dual specificity kinases. Thus, they are useful as pharmacological standards for use in the development of new biological tests and in the search for new pharmacological agents and pharmaceutical forms thereof.

HYDRATES AND SOLVATES

It is understood that when the phrase "pharmaceutically acceptable salts, solvates, and hydrates" or the phrase "pharmaceutically acceptable salt, solvate, or hydrate" is used when referring to compounds described herein, it embraces pharmaceutically acceptable solvates and/or hydrates of the compounds, pharmaceutically acceptable salts of the compounds, as well as pharmaceutically acceptable solvates and/or hydrates of pharmaceutically acceptable salts of the compounds. It is also understood that when the phrase "pharmaceutically acceptable solvates and hydrates" or the phrase "pharmaceutically acceptable solvate or hydrate" is used when referring to compounds described herein that are salts, it embraces pharmaceutically acceptable solvates and/or hydrates of such salts. Typical procedures for making and identifying suitable hydrates and solvates, outside those mentioned herein, are well known to those in the art; see for example, pages 202-209 of K.J. Guillory, "Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids," in: Polymorphism in Pharmaceutical Solids, ed. Harry G. Britain, Vol. 95, Marcel Dekker, Inc., New York, 1999.

CRYSTALLINE FORMS

Polymorphism is the ability of a substance to exist as two or more crystalline phases that have different arrangements and/or conformations of the molecules in the crystal lattice. Polymorphs show the same properties in the liquid or gaseous state but they may behave differently in the solid state.

Besides single-component polymorphs, drugs can also exist as salts and other

multicomponent crystalline phases. For example, solvates and hydrates may contain an active

pharmaceutical ingredient (API) host and either solvent or water molecules, respectively, as guests. Analogously, when the guest compound is a solid at room temperature, the resulting form is often called a cocrystal. Salts, solvates, hydrates, and cocrystals may show polymorphism as well.

Crystalline phases that share the same API host, but differ with respect to their guests, may be referred to as pseudopolymorphs of one another.

Solvates contain molecules of the solvent of crystallization in a definite crystal lattice.

Solvates, in which the solvent of crystallization is water, are termed hydrates. Because water is a constituent of the atmosphere, hydrates of drugs may be formed rather easily.

Recently, polymorph screens of 245 compounds revealed that about 90% of them exhibited multiple solid forms. Overall, approximately half the compounds were polymorphic, often having one to three forms. About one-third of the compounds formed hydrates, and about one-third formed solvates. Data from cocrystal screens of 64 compounds showed that 60% formed cocrystals other than hydrates or solvates. (G. P. Stahly, Crystal Growth & Design (2007), 7(6), 1007-1026.)

The present invention is directed, inter alia, to crystalline forms of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide and salts, hydrates, and solvates thereof. The crystalline forms of the present invention can be identified by unique solid state signatures with respect to, for example, differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and other solid state methods. Further characterization with respect to water or solvent content of the crystalline forms of the present invention can be gauged by any of the following methods for example, thermogravimetric analysis (TGA), DSC and the like. For DSC, it is known that the temperatures observed will depend upon sample purity, the rate of temperature change, as well as sample preparation technique and the particular instrument employed. Thus, the values reported herein relating to DSC thermograms can vary by about ± 6 °C. For desolvation events, DSC thermograms may vary by more than ± 6 °C depending on instrument configuration and/or sample quantity. The values reported herein relating to DSC thermograms can also vary by about ± 20 joules per gram. For XRPD, the relative intensities of the peaks can vary, depending upon the sample preparation technique, the sample mounting procedure and the particular instrument employed.

Moreover, instrument variation and other factors can often affect the 2Θ values. Therefore, the peak assignments of diffraction patterns can vary by about ± 0.2 °2Θ. The relative intensities of the reported peaks can also vary. For TGA, the features reported herein can vary by about ± 5 °C. The TGA features reported herein can also vary by about ± 2% weight change due to, for example, sample variation. Further characterization with respect to hygroscopicity of the crystalline form can be gauged by, for example, dynamic vapor sorption (DVS). The DVS features reported herein can vary by about ± 5% relative humidity. The DVS features reported herein can also vary by about ± 5% weight change.

Crystalline Form A of (j?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2.3-b]pyridin-3-yDcyclopropanecarboxamide

One aspect of the present invention is directed to a crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide having an X-ray powder diffraction pattern comprising a peak, in terms of °2Θ, at about 12.1. In some

embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 12.1, 19.9, and 19.5. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 12.1, 19.9, 19.5, 23.4, and 24.4. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 12.1, 19.9, 19.5, 23.4, 24.4, 9.7, and 29.4. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 9.7, 12.1, 16.1, 19.5, 19.9, 21.7, 23.4, 24.4, 27.0, 29.4, and 32.2. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising one or more peaks listed in Table 7. In some embodiments, the salt has an X-ray powder diffraction pattern substantially as shown in Figure 4, wherein by "substantially" is meant that the reported peaks can vary by about ± 0.2 °2Θ and also that the relative intensities of the reported peaks can vary.

In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram comprising an endotherm with an extrapolated onset temperature between about 258 °C and about 278 °C. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram comprising an endotherm with an extrapolated onset temperature at about 268° C. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram comprising an endotherm with an associated heat flow of about 95 joules per gram. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram substantially as shown in Figure 5, wherein by "substantially" is meant that the reported DSC features can vary by about ±6° C. and by about ±20 joules per gram.

In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a thermogravimetric analysis profile

substantially as shown in Figure 5, wherein by "substantially" is meant that the reported TGA features can vary by about ±5° C. and by about ±2% weight change.

Form A of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide can be prepared by any of the suitable procedures known in the art for preparing crystalline polymorphs. In some embodiments Form A of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide salt can be prepared as described in Example 4. In some embodiments, Form A of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide can be prepared by heating (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide containing one or more crystalline forms other than Form A. In some embodiments, Form A of (R)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide can be prepared by recrystallizing crystalline (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide containing one or more crystalline forms other than Form A.

Crystalline Form B of (j?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2.3-b]pyridin-3-yDcyclopropanecarboxamide

One aspect of the present invention is directed to a crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide having an X-ray powder diffraction pattern comprising a peak, in terms of °2Θ, at about 24.3. In some

embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 24.3, 20.0, and 13.6. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 24.3, 20.0, 13.6, 23.1, and 18.4. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 24.3, 20.0, 13.6, 23.1, 18.4, 31.8, and 27.3. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising peaks, in terms of °2Θ, at about 9.1, 13.6, 18.4, 18.8, 20.0, 20.9, 23.1, 24.3, 27.3, 28.8, and 31.8. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has an X-ray powder diffraction pattern comprising one or more peaks listed in Table 9. In some embodiments, the salt has an X-ray powder diffraction pattern substantially as shown in Figure 6, wherein by "substantially" is meant that the reported peaks can vary by about ± 0.2 °2Θ and also that the relative intensities of the reported peaks can vary.

In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry

thermogram comprising an endotherm with a peak between about 225 °C and about 245 °C. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram comprising an endotherm with a peak at about 235° C. In some embodiments, the crystalline form of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide has a differential scanning calorimetry thermogram substantially as shown in Figure 7, wherein by "substantially" is meant that the reported DSC features can vary by about ±6° C. and by about ±20 joules per gram.

Form B of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide can be prepared by any of the suitable procedures known in the art for preparing crystalline polymorphs. In some embodiments Form B of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide salt can be prepared as described in Example 5. In some embodiments, Form B of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide can be prepared by heating (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide containing one or more crystalline forms other than Form B. In some embodiments, Form B of (i?)-N-(4-(3-aminopiperidin- 1 -yl) -5 -bromo - 1 H-pyrrolo [2,3 -b] pyridin-3 -yl)cyclopropanecarboxamide can be prepared by recrystallizing crystalline (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide containing one or more crystalline forms other than Form B.

EXAMPLES

General Experimental

XRPD: XPvPD patterns were collected with a Rigaku SmartLab® diffractometer (Rigaku Corp., Tokyo, Japan), using an incident beam of Cu Ka ( 1.541904 A) radiation generated using Cross Beam optics (40 kV> 44 mA). Powder samples were packed using the top fill method onto zero-background holders and scans were acquired at a scan speed of 1° or 3.07min and step size of 0.02 or 0.04° 2Θ over 2-40° 2Θ range in the bragg-brentano or parallel beam configuration (reflection geometry). Data was analyzed using commercial software (JADE®, version 9, Materials Data Inc., Livermore, CA).

XRPD data were also obtained using a Rigaku MiniFlexII (Rigaku Corp., Tokyo, Japan) diffractometer. The radiation used was CuKa ( 1.541837 A) with voltage and current of 30 kV and 15 mA. Data was collected at ambient temperature from 2.0 to 40.0° 2Θ using a step size of 0.020°. A low background sample holder was used and the stage was rotated at a revolution time of 1.0 seconds. The incident beam path was equipped with a 0.02 rad soller slit, 15 mm mask, 4° fixed anti-scatter slit and a programmable divergence slit. The diffracted beam was equipped with a 0.02 rad soller slit, programmable anti-scatter slit and a 0.02 mm nickel filter.

DSC general conditions: DSC analysis was conducted on a TA Instruments Q 100 or Q2000 instrument. A sample size of approximately 1-5 mg was weighed out into a standard DSC pan; the pan was crimped. The sample was heated at 10 °C/min from ambient temperature to 250-300 °C under dry nitrogen at 50 mL/min.

TGA general conditions: TGA was conducted on a TA Instruments Q500 instrument. A sample size of approximately 1 -10 mg was used in a standard pan. The sample was heated at 10 7min from ambient temperature to 250-350 °C under dry nitrogen at 25 mL/min.

Example 1 Acetic acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo [2, 3 -b] pyridin-3 -yl)cyclopropanecarboxamide : (i?)-N-(4 -(3 -aminopiperidin- 1 -yl) -5 -bromo - 1 H- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (104 mg) was suspended in ethyl acetate ( 15 mL). Acetic acid ( 1.32 mL of a 0.2 mol/L solution in ethyl acetate) was added. The suspension was stirred for 1 week and the solid isolated by centrifugation and then analyzed. The physical properties of the non-solvated acetic acid salt of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3- b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 1 below.

Table 1


Certain XRPD diffraction peaks for the non-solvated acetic acid salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are

Table 2 below.

Table 2

SCAN: 3.0055/39.9125/0.013/1 (sec), Cu, l(p)=2941 , 02/17/16 10:23a

PEAK: 27(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 6.100 14.4774 694 1165 60.5 16310 46.5 0.155

2 9.816 9.0030 851 173 9.0 6372 18.2 0.407

3 10.191 8.6725 867 187 9.7 6521 18.6 0.385

4 12.923 6.8447 992 519 27.0 9460 27.0 0.201

5 13.576 6.5172 1005 204 10.6 5852 16.7 0.317

6 13.992 6.3242 1016 1925 100.0 25674 73.2 0.147

7 15.358 5.7649 1121 173 9.0 1882 5.4 0.120

8 16.239 5.4538 1097 1220 63.4 14429 41.1 0.131

9 17.203 5.1505 1169 321 16.7 3570 10.2 0.123

10 17.903 4.9505 1127 485 25.2 14808 42.2 0.338

11 18.282 4.8488 1172 1063 55.2 17346 49.4 0.180

12 19.097 4.6436 1148 396 20.5 5437 15.5 0.152

13 19.659 4.5122 1148 422 21.9 4810 13.7 0.126

14 20.387 4.3526 1150 998 51.8 17658 50.3 0.195

15 20.633 4.3013 1137 570 29.6 14078 40.1 0.273

16 20.894 4.2480 1134 880 45.7 17205 49.0 0.216

17 22.049 4.0281 1 131 418 21.7 9363 26.7 0.248

18 22.908 3.8791 1132 973 50.5 20919 59.6 0.238

19 23.234 3.8253 1 130 453 23.5 12979 37.0 0.317

20 24.066 3.6948 1 134 404 21.0 16578 47.2 0.453

21 24.274 3.6638 1 136 797 41.4 23288 66.4 0.323

22 24.508 3.6293 1 138 475 24.6 ' 14708 41.9 0.343

23 25.275 3.5209 1223 1577 81.9 35093 100.0 0.246

24 25.482 3.4927 1260 842 43.7 33509 95.5 0.440

25 25.913 3.4356 1180 1010 52.5 21026 59.9 0.230

26 26.250 3.3923 1180 632 32.8 14662 41.8 0.256

27 26.508 3.3598 1258 1294 67.2 21508 61.3 0.184

28 27.340 3.2595 1129 344 17.9 4394 12.5 0.141

29 27.771 3.2098 1 138 639 33.2 9239 26.3 0.160

30 28.096 3.1735 1144 758 39.4 13673 39.0 0.199

31 28.784 3.0991 1 120 1265 65.7 23997 68.4 0.210

32 29.148 3.0613 1096 401 20.9 7285 20.8 0.201

33 29.860 2.9898 1074 149 7.8 1872 5.3 0.139

34 30.228 2.9543 1068 370 19.2 6364 18.1 0.190

35 30.891 2.8923 1066 288 14.9 6602 18.8 0.254

36 31.619 2.8274 1064 111 5.8 3061 8.7 0.303

37 31.918 2.8016 1058 349 18.1 14746 42.0 0.467

38 32.255 2.7731 1053 376 19.5 14746 42.0 0.433

39 33.180 2.6978 1034 220 1 1.4 3939 1 1.2 0.198

40 34.050 2.6309 1011 274 14.2 3721 10.6 0.150

41 34.71 1 2.5823 1009 262 13.6 4729 13.5 0.199

42 35.338 2.5379 1036 241 12.5 3668 10.5 0.168

43 35.892 2.5000 1053 187 9.7 2440 7.0 0.144

44 . 36.481 2.4610 1040 109 5.7 2427 6.9 0.245

SCAN: 3.0055/39.9125/0.013/1 (sec), Cu, l(p)=2941 , 02/17/16 10:23a

PEAK: 27(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

2-Theta d(A) BG Height H% Area A% FWHM

37.118 2.4202 1034 699 36.3 16168 46.1 0.255

37.442 2.3999 1008 369 19.2 12498 35.6 0.374

47 38.225 2.3526 990' 158 8.2 1605 4.6 0.112

48 39.315 2.2898 985 248 12.9 5004 14.3 0.223

Example 2 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 - yl)cyclopropanecarboxamide ethanedisulfonic acid hydrate.

Method A: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide ( 101 mg) was suspended in ethyl acetate (15 mL). 1,2-Ethanedisulfonic acid (54.5 mg) was added and the suspension stirred for 1 day. The solid was isolated via centrifugation and then analyzed.

Method B: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide (-15 g) was weighed into a 250 mL round-bottom flask, and then -230 mL of isopropanol was added. 1.0 equivalent of 1,2-ethanedisulfonic acid was slowly added into the sample. Then the suspension was kept stirring on a magnetic stirrer at room temperature for 24 hrs. After that, acetone was added in order to obtain more solid precipitation. The solid was isolated by vacuum filtering. The sample was purified with acetone and dried under reduced pressure at 40 °C overnight.

The physical properties of the hydrate of the ethanedisulfonic acid salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 3 below.

Table 3


Certain XRPD diffraction peaks for the non-solvated acetic acid salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 4 below.

Table 4

SCAN: 3.0055/39.9125/0.013/1 (sec), Cu, l(p)=4426, 02/17/16 10:25a

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 5.852 15.0910 253 842 20.2 8732 18.4 0.115

2 8.984 9.8353 176 976 23.4 9148 19.2 0.104

3 10.595 8.3429 150 2638 63.3 25074 52.7 0.105

4 11.664 7.5805 148 1208 29.0 13250 27.9 0.121

5 12.650 6.9917 151 568 13.6 4978 10.5 0.097

6 13.471 6.5675 151 770 18.5 7647 16.1 0.110

7 14.185 6.2386 159 1114 26.7 11881 25.0 0.118

8 14.420 6.1374 164 256 6.1 3313 7.0 0.143

9 14.564 6.0771 153 247 5.9 3204 6.7 0.143

10 14.966 5.9150 167 777 18.6 15063 31.7 0.214

11 15.251 5.8048 168 373 9.0 5951 12.5 0.176

12 15.861 5.5829 159 952 22.9 8560 18.0 0.099

13 16.580 5.3424 164 66 1.6 491 1.0 0.083

14 17.021 5.2052 174 396 9.5 3968 8.3 0.11 1

15 17.591 5.0376 170 1354 32.5 15602 32.8 0.127

16 18.008 4.9219 174 404 9.7 5003 10.5 0.137

17 18.775 4.7225 205 557 13.4 6628 13.9 0.131

18 19.099 4.6432 204 379 9.1 3128 6.6 0.091

19 19.556 4.5358 224 587 14.1 6092 12.8 0.115

20 20.310 4.3689 259 225 5.4 2367 5.0 0.116

21 20.750 4.2772 223 320 7.7 4646 9.8 0.160

22 21.180 4.1915 259 4167 100.0 47577 100.0 0.126

23 21.466 4.1362 271 1028 24.7 22820 48.0 0.245

24 21.791 4.0753 271 3268 78.4 35338 74.3 0.119

25 22.207 3.9999 271 2079 49.9 28983 60.9 0.154

26 22.520 3.9450 271 1462 35.1 25680 54.0 0.194

27 22.740 3.9073 319 2256 54.1 33384 70.2 0.163

28 23.220 3.8275 271 394 9.4 ' 7175 15.1 0.201

29 23.441 3.7919 260 1291 31.0 17720 37.2 0.152

30 23.818 3.7328 244 71 1 17.1 9284 19.5 0.144

31 24.025 3.7011 235 406 9.7 9318 19.6 0.253

32 24.482 3.6330 212 71 1.7 967 2.0 0.151

33 24.975 3.5624 197 361 8.7 4695 9.9 0.144

34 25.431 3.4996 195 126 3.0 1843 3.9 0.161

35 25.795 3.4510 194 156 3.8 5399 11.3 0.382

36 26.0 6 3.4223 194 561 13.5 11498 24.2 0.227

37 26.470 3.3645 204 233 5.6 2224 4.7 0.106

38 27.159 3.2807 184 792 19.0 21 85 45.8 0.304

39 27.367 3.2562 179 973 23.4 19943 41.9 0.226

40 27.628 3.2260 1 2 234 5.6 3971 8.3 0. 88

41 28.342 3.1464 181 556 13.4 8623 18.1 0.171

42 28.797 3.0977 162 232 5.6 5833 12.3 0.278

43 29.044 3.0719 163 117 2.8 1995 4.2 0.189

44 29.344 3.0413 195 166 4.0 1988 4.2 0.133

SCAN: 3.0055/39.9125/0.013/1 (sec), Cu, l(p)=4426, 02/17/16 10:25a

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWH

45 29.941 2.9819 163 696 16.7 10780 22.7 0.171

46 30.486 2.9299 161 215 5.2 7550 15.9 0.388

47 30.762 2.9042 155 122 2.9 6641 14.0 0.601

48 31.125 2.8711 158 50 1.2 1532 3.2 0.339

49 31.384 2.8480 149 77 1.8 1532 3.2 0.220

50 32.099 2.7862 146 177 4.2 8796 18.5 0.550

51 32.424 2.7590 149 289 6.9 9870 20.7 0.377

52 32.932 2.7176 159 47 1.1 802 1 .7 0.187

53 33.286 2.6895 164 104 2.5 2741 5.8 0.290

54 33.543 2.6695 164 1 17 2.8 3361 7.1 0.318

55 33.971 2.6369 171 215 5.2 4667 9.8 0.240

56 34.255 2.6156 188 46 1.1 476 1 .0 0.1 14

57 34.673 2.5850 175 304 7.3 4597 9.7 0.167

58 35.053 2.5579 163 180 4.3 4641 9.8 0.285

59 35.271 2.5425 157 94 2.3 3419 7.2 0.402

60 36.246 2.4764 144 1.16 2.8 2631 5.5 0.251

61 36.705 2.4464 1 7 65 1.6 2488 5.2 0.423

62 37.246 2.4121 146 212 5.1 7887 16.6 0.410

63 37.508 2.3959 146 1 12 2.7 4546 9.6 0.449

64 38.235 2.3520 145 105 2.5 4349 9.1 0.457

65 38.418 2.3412 144 247 5.9 7053 14.8 0.315

66 38.743 2.3223 142 242 5.8 6371 13.4 0.290

Example 3 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide fumaric acid salt hydrate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (102 mg) was suspended in ethyl acetate (15 mL). Fumaric acid (34.5 mg) was added and the suspension stirred for 1 day. The solid was isolated by centrifugation and dried at room temperature under vacuum. The solid was exposed to 100% RH at room temperature for 3 days and then analyzed.

The physical properties of the hydrate of the fumaric acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 5 below.

Table 5

XRPD Figure 3.

Example 4 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Form A: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (28.6 mg) was dissolved in propyl acetate (6 mL) in a 20 mL vial. The material was allowed to evaporate at ambient to give Form A. Form A is a non-solvated crystalline form of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3- b]pyridin-3-yl)cyclopropanecarboxamide. The physical properties of Form A are summarized in Table 6 below.

Table 6


Certain XRPD diffraction peaks for (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Form A are shown in Table 7 below.

Table 7

SCAN: 4.0/40.0/0.04/1 (sec), Cu(40kV,44mA), l(p)=5467, 01/12/16 02:48p

PEAK: 11 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 9.371 9.4294 216 297 5.6 2546 12.2 0.291

2 9.677 9.1324 214 935 17.8 5164 24.8 0.188

3 12.146 7.2807 199 5268 100.0 18551 89.0 0.120

4 12.660 6.9864 215 185 3.5 1159 5.6 0.213

5 14.873 5.9517 174 302 5.7 1295 6.2 0.146

6 16.061 5.5138 168 876 16.6 4268 20.5 0.166

7 18.828 4.7094 171 416 7.9 1536 7.4 0.125

8 19.452 4.5596 211 2846 54.0 13626 65.4 0.163

9 19.932 4.4510 223 5108 97.0 20846 100.0 0.139

10 21.681 4.0957 217 578 1 1.0 2871 13.8 0.169

11 21.927 4.0502 215 250 4.8 1499 7.2 0.204

12 22.807 3.8959 217 225 4.3 907 4.4 0.137

13 23.396 3.7992 216 2195 41,7 10647 51.1 0.165

14 24.435 3.6400 209 1372 26.0 5520 26.5 0.137

15 25.480 3.4929 194 186 3.5 606 2.9 0.111

16 26.341 3.3807 191 91 1.7 291 1.4 0.109

17 27.01 1 3.2983 182 673 12.8 3405 16.3 0.172

18 28.1 3 3.1649 187 112 2.1 514 2.5 0.157

19 29.008 3.0757 206 407 7.7 2359 11.3 0.197

20 29.364 3.0392 188 890 16.9 5866 28.1 0.224

21 29.752 3.0004 190 144 2.7 1708 8.2 0.402

22 30.891 2.8923 182 288 5.5 1054 5.1 0.124

23 32.211 2.7768 206 880 16.7 5107 24.5 0.197

24 32.724 2.7344 204 99 1.9 1591 7.6 0.547

25 35.973 2.4945 163 118 2.2 755 3.6 0.218

26 36.313 2.4719 165 119 2.3 865 4.1 0.246

27 36.981 2.4288 171 83 1.6 1024 4.9 0.421

28 37.363 2.4048 178 181 3.4 2093 10.0 0.393

29 37.719 2.3830 83 90 1.7 532 2.5 0.202

30 38.517 2.3354 206 101 1.9 993 4.8 0.334

31 39.196 2.2965 219 52 1.0 881 4.2 0.575

Example 5 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 -yl)cyclopropanecarboxamide Form B: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (24.6 mg) was dissolved in ethyl formate (5 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions. The sample could be heated to 130 °C in a TGA under nitrogen (10 °C/min to 140 °C and then cooled to ambient) to remove solvent. Form B is a non-solvated crystalline form of the free base of (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide . The physical properties of Form B are summarized in Table 8 below.

Table 8

XRPD Figure 6: Peaks of > 25% relative height at about 9.1, 13.6, 18.4, 18.8,

20.0, 20.9. 23.1, 24.3, 27.3, 28.8. and 31.8 °2Θ.

DSC Figure 7: Endotherm at about 235 °C.

Certain XRPD diffraction peaks for (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, Form B are shown in Table 9 below.

Table 9

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=317.0, 1 1/02/12 01 :49p

PEAK: 25(pts)/Parabolic Filter, Thresho!d=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 9.102 9.7081 21 61 25.4 599 10.1 0.166

2 10.460 8.4505 23 31 12.9 294 5.0 0.161

3 12.341 7.1662 22 39 16.4 609 10.3 0.263

4 13.561 6.5242 25 195 80.9 2610 44.1 0.228

5 15.338 5.7721 27 37 15.4 778 13.1 0.356

6 16.303 5.4326 33 35 14.3 829 14.0 0.408

7 18.439 4.8079 53 89 37.0 1999 33.8 0.381

8 18.838 4.7070 53 62 25.8 1141 19.3 0.312

9 19.081 4.6475 56 55 22.6 2027 34.2 0.631

10 20.000 4.4359 56 212 87.7 5919 100.0 0.476

11 20.678 4.2920 56 60 24.7 1860 31.4 0.531

12 20.923 4.2423 56 70 28.8 1226 20.7 0.300

13. 22.339 3.9765 87 58 24.1 922 5.6 0.270

14 23.062 3.8534 85 115 47.6 1770 29.9 0.262

15 24.279 3.6629 76 241 100.0 5108 86.3 0.360

16 24.858 3.5790 83 55 23.0 1381 23.3 0.424

17 27.320 3.2617 72 74 30.7 875 14.8 0.201

18 28.839 3.0933 69 61 25.3 1466 24.8 0.409

19 31.783 2.8132 71 78 32.3 1977 33.4 0.431

20 33.143 2.7008 70 51 21.1 1016 17.2 0.340

21 38.416 2.3413 63 43 17.9 1171 19.8 0.460

22 38.857 2.3 57 62 29 12.1 777 13.1 0.453

Example 6 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide cyclopropyl methyl ether solvate.

Method A: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (27.2 mg) was dissolved in cyclopentyl methyl ether (7.5 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions.

Method B: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo- lH-pyrrolo[2,34j]pyridin-3-yl)cyclopropanecarboxamide was dissolved at 200 mg/mL in pyridine 65 °C. The solution was diluted to 10 mg/mL with cyclopentyl methyl ether and cooled from 65 °C to 10 °C over 14.5 h. The mixture was allowed to evaporate until dry to yield the cyclopentyl methyl ether solvate.

The physical properties of the cyclopropyl methyl ether solvate of the free base of (i?)-N-(4- (3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 10 below.

Table 10


Certain XRPD diffraction peaks for the cyclopropyl methyl ether solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 1 1 below.

Table 11

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=1048, 10/24/12 11 :28a

PEAK: 27(pts)/Parabolic Filter, Threshoid=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 9.877 8.9479 61 280 30.0 3364 14.7 0.204

2 10.600 8.3391 105 671 71.9 18612 81.5 0.471

3 12.119 7.2971 85 94 10.1 927 4.1 0.168

4 15.160 5.8396 100 167 17.9 3160 13.8 0.321

5 18.860 4.7014 114 934 100.0 22831 100.0 0.416

6 19.802 4.4800 141 882 94.5 13810 60.5 0.266

7 21.803 4.0730 132 114 12.2 2233 9.8 0.333

8 22.236 3.9946 163 93 9.9 4418 19.4 0.809

9 22.681 3.9172 116 230 24.6 10284 45.0 0.760

10 23.057 3.8542 116 143 15.3 5002 21.9 0.594

11 23.863 3.7259 1 14 55 5.8 1557 6.8 0.486

12 24.302 3.6595 1 12 69 7.4 1557 6.8 0.385

13 26.001 3.4242 109 335 35.8 9055 39.7 0.460

14 27.944 3.1903 111 72 7.7 975 4.3 0.231

15 28.377 3.1426 110 37 4.0 1889 8.3 0.862

16 28.943 3.0824 120 52 5.5 619 2.7 0.204

17 29.919 2.9840 109 228 24.5 2837 12.4 0.211

18 31.783 2.8132 96 195 20.9 3113 13.6 0.272

19 36.603 2.4530 75 54 5.8 780 3.4 0.246

20 37.119 2.4201 69 121 13.0 3293 14.4 0.463

Example 7 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide 1,2-dichloroethane solvate.

Method A: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide (29.8 mg) was dissolved in 1,2-dichloroethane (4 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions.

Method B : (R) -N-(4-(3 -aminopiperidin- 1 -yl) -5 -bromo- 1 H-pyrrolo [2, 3 -b] pyridin-3 - yl)cyclopropanecarboxamide was dissolve at 33.3 mg/mL in 2: 1 (v/v) 1,2-dichloroethane methanol at 65 °C. The solution was cooled from 65 °C to 10 °C over 14.5 h, then evaporated to until dry to yield (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1,2-dichloroethane solvate.

The physical properties of the 1,2-dichloroethane solvate of the free base of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 12 below.

Table 12


Certain XRPD diffraction peaks for the 1,2-dichloroethane solvate of the free base of (R)-N- (4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 13 below.

Table 13

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV, 15mA), l(p)=1112, 10/24/12 11 :47a

PEAK: 17(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 8,635 10.2324 9 131 12.2 1439 12.8 0.186

2 9.882 8.9437 10 169 15.7 1620 14.4 0.163

3 12.612 7.0130 12 82 7.6 842 7.5 0. 74

4 15.780 5.61 15 17 160 14.8 1676 14.9 0.178

5 16.726 5.2960 21 85 7.9 871 7.8 0.174

6 17.258 5.1341 23 400 37.1 4107 36.6 0.175

7 18.262 4.8541 23 122 11.3 1038 9.3 0.145

8 19.042 4.6570 22 125 11.6 1327 11.8 0.180

9 19.484 4.5522 25 31 2.9 563 5.0 0.306

10 19.900 4.4579 35 676 62.7 4949 44.1 0.124

11 21.323 4.1636 30 210 19.5 2872 25.6 0.232

12 21.781 4.0772 31 135 12.6 1619 14.4 0.203

13 22.242 3.9935 43 108 10.1 954 8.5 0.150

14 23.581 3.7697 34 1078 100.0 11212 100.0 0.177

15 24.222 3.6715 40 49 4.6 387 3.5 0.134

16 25.081 3.5477 40 413 38.3 5700 50.8 0.235

17 25.999 3.4244 40 401 37.2 5083 45.3 0.215

18 27.140 3.2829 36 152 14.1 2916 26.0 0.326

19 27.378 3.2550 39 101 9.3 2062 18.4 0.348

20 27.780 3.2088 38 32 3.0 41 1 3.7 0.218

21 ' 27.985 3.1858 34 62 5.8 927 8.3 0.254

22 29.258 3.0499 36 30 2.8 196 1.7 0.111

23 30.820 2.8989 52 142 13.2 1078 9.6 0.129

24 31.537 2.8346 42 270 25.1 5076 45.3 0.319

25 31.859 2.8066 35 135 12.6 3485 31.1 . 0.438

26 32.321 2.7676 35 85 7.8 984 8.8 0.198

27 33.336 2.6856 38 55 5.1 556 5.0 0.173

28 33.902 2.6420 42 79 7.4 750 6.7 0.161

29 34.555 2.5936 36 77 7.1 1633 14.6 0.363

30 34.937 2.5661 38 33 3.1 635 5.7 0.325

31 35.761 2.5088 35 50 4.6 1005 9.0 0.345

32 36.393 2.4667 34 34 3.2 930 8.3 0.465

33 37.981 2.3671 34 44 4.1 774 6.9 0.301

34 38.437 2.3401 40 50 4.7 1 03 15.2 0.576

35 38.779 2.3203 40 45 4.2 899 8.0 0.337

36 39.277 2.2920 40 58 5.4 1190 10.6 0.347

37 39.539 2.2774 40 49 4.6 1190 10.6 0.410

Example 8 (i?)-N-(4-(3-aminopiperidin- l-yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2-methyltetrahydrofuran solvate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (28.1 mg) was dissolved in 2-methyltetrahydrofuran (2 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions.

The physical properties of the 2-methyltetrahydrofuran solvate of the free base of (i?)-N-(4- (3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 14 below.

Table 14


Certain XRPD diffraction peaks for the 2-methyltetrahydrofuran solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 15 below.

Table 15

SC AN : 2.0/40.0/0.02/0.6(s ec) , Cu(30kV,15mA), l(p)=934.0, 10/25/12 09:24a

PEAK: 45(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

2-Theta d(A) BG Height H% Area A% FWHM

9.400 9.4009 37 258 29.0 3707 20.8 0.244

10.521 8.4016 109 345 38.8 17692 99.1 0.871

12.161 7.2723 45 889 100.0 16226 90.9 0.310

18.920 4.6866 71 396 44.6 17856 100.0 0.766

19.921 4.4535 71 410 46.1 9713 54.4 0.402

22.903 3.8798 119 86 9.7 2627 14.7 0.517

7 24.460 3.6363 103 449 50.5 10024 56.1 0.380

8 26.195 3.3993 125 51 5.7 2223 12.4 0.741

9 26.901 3.3116 118 92 10.3 3336 18.7 0.619

10 32.043 2.7909 72 101 11.4 1808 10.1 0.304

11 37.221 2.4137 64 100 11.3 3275 18.3 0.555

For single crystal X-ray diffraction, (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was dissolved at 500 mg/mL in 2,2,2- trifluoroethanol at 65 °C. The solution was diluted to 25 mg/mL with 2-methyltetrahydrofuran and cooled from 65 °C to 10 °C over 14.5 h. Crystals for diffraction were pulled directly from resulting saturated solution. A colorless plate of Ci6H2oBrN50 having approximate dimensions of 0.20 χ 0.20 χ 0.12 mm was mounted on a fiber in a random orientation. Preliminary examination and data collection were performed Cu Ka radiation (1 = 1.54184A) on a Rigaku Rapid II equipped with confocal optics. The data were collected at a temperature of 150(1)K. Cell constants for data collection were obtained from least-squares refinement, using the setting angles of 35,637 reflections in the range 3 < q < 70°.

The space group was determined by the program XPREP. There were no systematic absences; the space group was determined to be P -1(# 2). A total of 35,637 reflections were collected, of which 7,284 were unique. Frames were integrated using program CrystalClear. Lorentz and polarization corrections were applied to the data. An empirical absorption correction using CrystalClear was applied. Transmission coefficients ranged from 0.425 to 0.716. Intensities of equivalent reflections were averaged. The structure was solved by direct methods using Charge Flipping in PLATON. The remaining atoms were located in succeeding difference Fourier syntheses. Hydrogen atoms were included in the refinement but restrained to ride on the atom to which they are bonded. The structure was refined in full-matrix least-squares where the function minimized was Sw(|Fo|2-|Fc|2)2 and the weight w is defined as l/[s2(Fo2)+(0.1012P)2+10.7676P] where P=(Fo2 +2Fc2)/3. Scattering factors were taken from the "International Tables for Crystallography". Residual electron density was adjusted using the SQUEEZE option in PLATON. Refinement was performed on a LINUX PC using SHELX-97. The crystal structure of the asymmetric unit of the 2-methyltetrahydrofuran solvate is shown in Figure 14.

Example 9 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide 1-pentanol solvate: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (26.5 mg) was dissolved in 1-pentanol (1.5 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions. The physical properties of the 1-pentanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)- 5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 16 below.

Table 16


Certain XRPD diffraction peaks for the 1-pentanol solvate of the free base of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 17 below.

Table 17

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=617.0, 10/25/12 09:43a

PEAK: 21 (pts)/Parabolic Filter, Thresho!d=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWH

1 8.640 10.2264 23 235 44.0 2785 42.8 0.202

2 9.462 9.3394 23 84 15.8 2453 37.7 0.494

3 9.661 9.1471 16 141 26.4 2572 39.6 0.310

4 12.041 7.3440 21 122 22,8 1531 23.5 0.214

5 15.340 5.7716 24 333 62.5 3734 57.4 0.191

6 15.764 5.6172 33 64 12.0 1008 15.5 0.267

7 16.237 5.4544 33 69 13.0 1001 15.4 0.246

8 17.381 5.0982 37 205 38.6 2300 35.4 0.190

9 18.342 4.8330 50 68 12.8 464 7.1 0.115

10 19.021 4.6620 47 82 15.4 3022 46.5 0.624

11 19.501 4.5484 51 259 48.6 5129 78.9 0.336

12 19.936 4.4500 51 66 12.4 1469 22.6 0.378

13 20.899 4.2471 51 40 7.5 455 7.0 0.193

14 21.356 4.1572 71 367 68.9 4393 67.6 0.203

15 22.160 4.0082 76 202 37.9 2975 45.8 0.250

16 23.121 3.8437 84 533 100.0 6502 100.0 0.207

17 24.101 3.6896 52 182 34.1 5195 79.9 0.485

18 26.221 3.3959 49 285 53.5 5358 82.4 0.319

19 27.036 3.2953 48 138 26.0 2228 34.3 0.274

20 29.081 3.0681 46 84 15.7 971 14.9 0.197

21 29.975 2.9786 47 27 5.1 303 4.7 0.188

22 31.437 2.8434 64 145 27.2 3730 57.4 0.438

23 32.198 2.7779 61 45 8.4 697 10.7 0.266

24 33.426 2.6786 46 32 6.1 345 5.3 0.182

25 34.101 2.6271 48 30 5.7 414 6.4 0.233

26 34.639 2.5875 47 70 13.0 1621 24.9 0.396

27 36.222 2.4780 52 59 11.1 " 901 13.9 0.258

28 39.557 2.2764 55 28 5.2 335 5.2 0.206

Example 10 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 - yl)cyclopropanecarboxamide pyridine solvate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (29.9 mg) was dissolved in pyridine (1 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The vial top was left open and the solution evaporated under ambient conditions. The physical properties of the pyridine solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5- bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 18 below.

Table 18


Certain XRPD diffraction peaks for the pyridine solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,34o]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 19 below.

Table 19

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=647.0, 10/25/12 11 :01a

PEAK: 23(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWH

1 8.203 10.7695 11 49 8.0 578 6.0 0.199

2 9.586 9.2188 13 46 7.5 597 6.2 0.219

3 10.839 8.1558 19 540 87.3 5609 57.9 0.176

4 12.503 7.0742 18 79 12.8 064 11.0 0.228

5 14.276 6.1993 21 79 12.8 823 8.5 0.176

6 16.275 5.4418 25 163 26.4 2384 24.6 0.249

7 16.679 5.3109 28 43 6.9 417 4,3 0.165

8 18.800 4.7162 28 602 97.3 7107 73.4 0.201

9 19.320 4.5905 28 619 100.0 9214 95.1 0.253

10 19.621 4.5207 28 468 75.6 9688 100.0 0.352

11 20.102 4.4138 28 60 9.7 1044 10.8 0.297

12 21.220 4.1836 52 301 48.7 5459 56.3 0.308

13 21.682 4.0955 51 457 73.8 7775 80.3 0.289

14 22.379 3.9695 51 409 66.1 6782 70.0 0.282

15 22.999 3.8639 51 176 28.4 2551 26.3 0.247

16 23.479 3.7859 66 138 22.3 1277 13.2 0.157

17 24.041 3.6987 56 68 11.0 648 6.7 0.162

18 24.416 3.6427 54 74 11.9 1090 11.2 0.252

19 24.794 3.5880 53 30 4.8 358 3.7 0.203

20 25.262 3.5226 50 48 7.8 1454 15.0 0.514

21 25.465 3.4950 49 74 12.0 1454 15.0 0.332

22 26.559 3.3535 43 87 14.1 1883 19.4 0.367

23 27.006 3.2990 42 70 11.4 1285 13.3 0.311

24 28.059 3.1775 41 125 20.2 1668 17.2 0.226

25 28.401 3.1400 41 96 15.6 2265 23.4 0.400

26 28.858 3.0914 41 136 22.0 4122 42.5 0.514

27 29.821 2.9936 41 214 34.6 261 1 26.9 0.207

28 30.442 2.9340 41 64 10.4 1514 15.6 0.400

29 30.799 2.9008 41 93 15.1 2034 21.0 0.371

30 31.301 ' 2.8554 41 117 19.0 3950 40.8 0.572

31 31.937 2.7999 41 164 26.6 5554 57.3 0.575

32 32.740 2.7331 50 105 17.0 2400 24.8 0.388

33 34.958 2.5646 50 35 5.7 616 6.4 0.297

34 35.657 2.5159 63 62 10.0 565 5.8 0.155

35 37.263 2.41 11 61 79 12.7 2159 22.3 0.466

36 37.521 2.3951 57 76 12.4 2407 24.8 0.535

37 38.661 2.3271 56 59 9.5 365 3.8 0.106

38 39.316 2.2898 66 78 12.7 2725 28.1 0.590

Example 1 1 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide 1,4-dioxane solvate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (26.1 mg) was dissolved in 1,4-dioxane (1.5 mL) in a 20 mL scintillation vial at room temperature. The solution was filtered and placed into a clean 20 mL scintillation vial. The top was covered tightly with aluminum foil and allowed to evaporate under ambient conditions. The physical properties of the 1,4-dioxane solvate of the free base of (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- 1 H-pyrrolo[2,3 -b]pyridin-3 - yl)cyclopropanecarboxamide are summarized in Table 20 below.

Table 20


Certain XRPD diffraction peaks for the 1,4-dioxane solvate of the free base of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 21 below.

Table 21

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=269.0, 10/29/12 12:1 1 p

PEAK: 27(pts)/Parabolic Filter, Threshoid=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWH

1 10.960 8.0663 11 163 64.8 2125 32.9 0.221

2 12.944 6.8338 11 49 19.3 681 10.5 0.238

3 13.723 6.4478 18 46 18.2 273 4.2 0.101

4 16.860 5.2543 15 51 20.3 1010 15.6 0.335

5 18.780 4.7212 17 252 100.0 4273 66.2 0.288

6 19.359 4.5814 17 137 54.4 2719 42.1 0.337

7 19.940 4.4492 17 223 88.5 3959 61.3 0.301

8 20.600 4.3082 17 132 52.4 1977 30.6 0.254

9 21.261 4.1757 17 83 33.0 1243 19.3 0.254

10 21.743 4.0840 17 128 50.8 6259 96.9 0.829

1 1 22.340 3.9763 24 190 75.3 6457 100.0 0.578

12 23.557 3.7736 27 33 13.0 486 7.5 0.252

13 24.080 3.6927 26 62 24.4 991 15.3 0.274

14 25.145 3.5388 24 27 10.7 257 4.0 0.162

15 26.521 3.3581 22 71 28.1 1232 19.1 0.296

16 27.503 3.2405 22 38 15.2 696 10.8 0.309

17 28.417 3.1383 22 78 31.0 1843 28.5 0.400

18 29.420 3.0335 22 1 11 44.1 2614 40.5 0.399

19 31.744 2.8165 28 65 25.7 3183 49.3 0.834

20 32.419 2.7595 38 54 21.6 2453 38.0 0.766

21 34.278 2.6139 32 27 10.9 666 10.3 0.413

22 37.916 2.3710 37 40 16.0 391 6.1 0.165

23 39.314 2.2899 42 44 17.5 1121 17.4 0.431

Example 12 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 - yl)cyclopropanecarboxamide 2-butanol solvate: 2-butanol (1.5 niL) and heptane (7.5 mL) were added to (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide (25.9 mg). The mixture was placed in the refrigerator at approximately 5 °C for 5 days. Solvent was removed from the suspension while still cold and the material analyzed while still damp with solvent. The physical properties of the 2-butanol solvate of the free base of (R)- N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 22 below.

Table 22


Certain XRPD diffraction peaks for the 2-butanol solvate of the free base of (Λ)-Ν-(4-(3- aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown ' Table 23 below.

Table 23

SCAN: 2.0/40,0/0.02/0.6(sec), Cu(30kV,15mA), I (p)=559.0, 11/19/12 10:19a

PEAK: 27(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWH

1 8.279 10.6709 10 221 41.9 4905 42.6 0.377

2 8.940 9.8841 11 96 18.1 2073 18.0 0.369

3 9.502 9.3004 11 411 77.8 3632 31.6 0.150

4 11.193 7.8985 15 69 13.2 728 6.3 0.178

5 14.521 6.0948 13 393 74.6 5025 43.7 0.217

6 15.148 5.8440 13 51 9.7 861 7.5 0.285

7 16.520 5.3619 19 107 20.4 4078 35.4 0.645

8 18.018 4.9193 19 114 21.7 2948 25.6 0.438

9 19.078 4.6481 19 424 80.4 6836 59.4 0.274

10 19.721 4.4981 19 88 16.8 2054 17.8 0.395

11 21.500 4. 297 31 401 75.9 10031 87.2 0.426

12 22.379 3.9694 31 528 100.0 11508 100.0 0.371

13 24.518 3.6278 44 56 10.6 1242 10.8 0.378

14 27.078 3.2904 47 183 34.8 4405 38.3 0.408

15 28.279 3.1533 50 44 8.3 444 3.9 0.173

16 30.042 2.9721 67 81 15.4 1008 8.8 0.211

17 30.837 2.8973 69 87 16.5 1578 13.7 0.308

18 31.678 2.8222 38 92 17.4 1802 15.7 0.333

19 32.979 2.7138 38 43 8.2 1141 9.9 0.451

20 33.903 2.6419 38 53 10.0 1919 16.7 0.616

21 34.779 2.5774 38 42 8.0 1380 12.0 0.559

22 34.981 2.5629 38 51 9.7 1380 12.0 0.460

23 36.278 2.4743 54 77 14.5 2024 17.6 0.449

Example 13 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide anisole solvate.

Method A: (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (27.6 mg) was dissolved in anisole (4 mL) at approximately 60 °C. The solution was removed from the cooling block and allowed to cool to ambient. The vial was then placed into a freezer at about -18 °C and left there for 3 weeks. The solvent was removed while the sample was still cold and the solid analyzed while still damp with solvent.

Method B: (R)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was dissolved at 25 mg/mL in anisole 65 °C, and cooled from 65 °C to 10 °C over 14.5 h. Solids were isolated via filtration to yield (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,34j]pyridin-3-yl)cyclopropanecarboxamide anisole solvate.

The physical properties of the anisole solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 24 below.

Table 24


Certain XRPD diffraction peaks for the anisole solvate of the free base of (i?)-N-(4-(3- aminopiperidin-1 -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown ' Table 25 below.

Table 25

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=587.0, 12/03/12 02:55p

PEAK: 27(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 9.156 9.6509 11 62 11.0 1049 10.7 0.287

2 9.441 9.3600 15 81 14.4 1722 17.5 0.362

3 9.978 8.8576 15 35 6.2 428 4.4 0.209

4 0.678 8.2788 30 43 7.6 627 6.4 0.249

5 15.144 5.8456 31 50 8.9 1000 10.2 0.338

6 15.596 5.6771 35 105 18.7 1427 14.5 0.230

7 16.197 5.4678 37 38 6.8 314 3.2 0.139

8 6.658 5.3177 31 74 13.2 680 6.9 0.156

9 18.335 4.8349 25 23 4.1 287 2.9 0.212

10 18.919 4.6869 24 563 100.0 9835 100.0 0.297

11 19.520 4.5438 24 207 36.7 7786 79.2 0.640

12 20.002 4.4355 24 100 17.7 1811 18.4 0.309

13 20.662 4.2953 24 139 24.7 2126 21.6 0.261

14 21.400 4.1487 24 347 61.6 6203 63.1 0.304

15 22.243 3.9935 24 77 13.6 1200 12.2 0.266

16 22.901 3.8802 24 272 48.3 6568 66.8 0.411

17 24.118 3.6870 39 96 17.1 1747 17.8 0.309

18 24.503 3.6300 39 28 5,0 490 5.0 0.296

19 25.120 3.5422 38 49 8.7 505 5.1 0.175

20 27.720 3.2156 40 69 , 12.3 930 9.5 0.228

21 29.280 3.0477 77 80 14.1 1062 10.8 0.227

22 29.684 3.0071 69 95 16.8 1621 16.5 0.291

23 31.277 2.8575 62 61 10.8 663 6.7 0.185

24 31.550 2.8334 54 83 14.8 2800 28.5 0.572

25 32.001 2.7945 57 47 8.4 1348 13.7 0.486

26 34.279 2.6139 38 28 4.9 404 4.1 0.248

27 37.140 2.4188 51 50 8.8 566 5.8 0.194

Example 14 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 1-propanol solvate: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was suspended at 60 °C in heptane (lmL). 1-Propanol (2 mL) was added. The solids dissolved. The solution allowed to cool to ambient. The vial was then placed into a freezer at about -18 °C and left there for 3 weeks. The solvent was removed while the sample was still cold and the solid analyzed while still damp with solvent. The physical properties of the 1-propanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 26 below.

Table 26

XRPD Figure 25 : Peaks of > 20% relative height at about 8.4, 9.4, 14.5, 17.7,

19.0, 21.5, 21.8, 22.3, 22.6, and 26.8 °2Θ.

Certain XRPD diffraction peaks for the 1-propanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 27 below.

Table 27

SCAN; 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=446.0, 12/18/12 09;44a

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 8.438 10.4709 11 172 41.3 3015 35.4 0.297

2 8.822 10.0153 14 92 22.1 1915 22.5 0.353

3 9.441 9.3603 12 233 55.7 2482 29.1 0.181

4 11.138 7.9373 12 63 15.2 697 8.2 0.187

5 14.539 6.0877 11 369 88.2 4456 52.3 0.206

6 15.179 5.8323 11 34 8.0 588 6.9 0.298

7 16.301 5.4333 19 56 13.3 792 9.3 0.242

8 16.998 5.2119 28 84 20.0 1792 21.0 0.364

9 17.740 4.9955 26 160 38.3 2012 23.6 0.214

10 18.580 4.7717 30 45 10.7 598 7.0 0.227

11 19.000 4.6672 34 268 64.1 3122 36.6 0.198

12 21.079 4.2112 24 42 10.1 498 5.8 0.201

13 21.462 4.1370 27 297 71.0 6018 70.6 0.345

14 21.842 4.0658 28 271 64.8 6637 77.9 0.417

15 22.261 3.9903 28 418 100.0 8520 100.0 0.347

16 22.641 3.9242 41 116 27.9 1302 15.3 0.190

17 24.561 3.6216 34 70 16.7 778 9.1 0.189

18 25.357 3.5096 33 25 6.0 588 6.9 0.402

19 26.841 3,3189 33 121 29.0 2977 34.9 0.417

20 27.592 3.2302 29 27 6.6 420 4.9 0.261

21 29.279 3.0478 31 37 8.9 803 9.4 0.368

22 29.902 2.9857 32 74 17.7 1288 15.1 0.295

23 30.519 2.9267 46 53 12.7 803 9.4 0.256

24 30.873 2.8940 43 45 10.7 439 5.2 0.167

25 31.678 2.8223 27 56 13.5 992 1 1.6 0.299

26 33.500 2.6728 34 33 8.0 674 7.9 0.343

27 34.864 2.5713 37 56 13.5 891 10.5 0.269

28 35.827 2.5044 37 25 5.9 153 1.8 0.106

29 36.161 2.4820 32 53 12.6 1338 15.7 0.433

30 39.442 2.2828 35 33 7.9 495 5.8 0.254

Example 15 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,34j]pyridin-3 -yl)cyclopropanecarboxamide bis-ethanol solvate.

Method A: A saturated solution of (i?)-N-(4-(3-aminopiperidin-l -yl)-54jromo-lH-pyrrolo[2,34o]pyridin-3-yl)cyclopropanecarboxamide was generated at 65°C without stirring and the sample was held at 65 °C for 24 hours. Solid consisting of plates were observed above the liquid level. The solution was cooled to room temperature.

Method B: A saturated solution of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was generated in ethanol at room temperature. The solution was subjected to vapor diffusion using water and isooctane. The vial within vials were placed in a refrigerator at about 5-10°C to give some plates of the ethanol solvate.

A yellow plate 0.050 χ 0.040 χ 0.030 mm in size was mounted on a Cryoloop with Paratone oil. Data were collected in a nitrogen gas stream at 100(2) K using and scans. Crystal-to-detector distance was 60 mm and exposure time was 5 seconds per frame using a scan width of 2.0°. Data collection was 98.4% complete to 67.000° in q. A total of 32,872 reflections were collected covering the indices, -1 \<=h<=\ 1, -1 \<=k<=\ 1, -15<=/<=15. 7,254 reflections were found to be symmetry independent, with an Rint of 0.0248. Indexing and unit cell refinement indicated a primitive, triclinic lattice. The space group was found to be P 1 (No. 1). The data were integrated using the Bruker SAINT software program and scaled using the SADABS software program. Solution by iterative methods (SHELXT-2014) produced a complete heavy-atom phasing model consistent with the proposed structure. All non-hydrogen atoms were refined anisotropically by full-matrix least-squares (SHELXL-2014). All hydrogen atoms were placed using a riding model. Their positions were constrained relative to their parent atom using the appropriate HFIX command in SHELXL-2014. The crystal structure of the asymmetric unit for the bis-ethanol solvate is shown in Figure 26.

The XPvPD of the bis-ethanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, as calculated from the SCXRD data at 100 K, is shown in Figure 28 and summarized in Table 28 below.

Table 28

XRPD Figure 27: Peaks of > 30% relative height at about 9.5, 14.6, 18.0, 19.8,

20.2, 20.4, 21.7, 21.9, 22.1, 23.0, 23.7, 24.7, and 29.7 °2Θ.

Certain calculated XRPD diffraction peaks for the bis-ethanol solvate of the free base of (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 29 below.

Table 29

SCAN: 2.0/40.0/0.02/0.1 (sec), Cu, l(p)=10000, 02/05/16 11 : 12a

PEAK: 15(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWH

1 7.338 12.0378 8 1491 15.0 10309 13.2 0.118

2 9.537 9.2664 32 9968 100.0 78258 100.0 0.133

i 3 9.858 8.9651 31 2871 28.8 34398 44.0 0.204

4 11.280 7.8380 10 1 90 11.9 8194 10.5 0.1 17

5 . 12.520 7.0642 10 498 5.0 3572 4.6 0.122

6 13.098 6.7536 11 584 5.9 5617 7.2 0.163

7 14.139 6.2588 35 2907 29.2 23604 30.2 0.138

8 14.557 6.0800 40 3315 33.3 29799 38.1 0.153

9 15.083 5.8691 39 2409 24.2 16922 21.6 0.1 19

10 16.383 5.4063 47 2000 20.1 14372 18.4 0.122

11 16.758 5.2860 53 1729 17.3 12328 15.8 0.121

12 18.000 4.9241 64 . 6375 64.0 42365 54.1 0.1 13

13 19.121 4.6378 71 2340 23.5 17156 21.9 0.125

14 19.783 4.4841 71 7857 78.8 62870 80.3 0.136

15 20.201 4.3923 71 5057 50.7 55380 70.8 0.186

16 20.399 4.3501 71 3309 33.2 38500 49.2 0.198

17 20.897 4.2475 71 1902 19.1 15605 19.9 0.139

18 21.683 4.0953 277 8971 90.0 75923 97.0 0.144

19 21.921 4.0514 277 8357 83.8 74257 94.9 0.151

20 22.141 4.01 17 277 9328 93.6 77230 98.7 0.141

21 22.402 3.9655 277 2359 23.7 23831 30.5 0.172

22 22.820 3.8938 320 2037 20.4 29004 37.1 0.242

23 23.023 3.8598 251 4270 42.8 32690 41.8 0.130

24 23.663 3.7569 195 4577 45.9 40247 51.4 0.149

25 23.860 3.7263 195 757 7.6 15074 19.3 0.338

26 24.343 3.6535 109 1296 13.0 10236 13.1 0.134

27 24.679 3.6045 111 4026 40.4 34332 43.9 0.145

28 24.937 3.5677 88 2133 21.4 18544 23.7 0.148

29 25.197 3.5316 88 472 4.7 5059 6.5 0.182

30 25.539 3.4850 98 167 1.7 780 1.0 0.079

31 25.785 3.4524 101 198 2.0 864 1.1 0.074

32 26.257 3.3913 88 1728 17.3 11091 14.2 0.109

33 26.717 3.3340 88 839 8.4 5522 7.1 0.112

34 27.096 3.2882 125 851 8.5 8269 10.6 0.165

35 27.340 3.2594 85 1009 10.1 8744 11.2 0.147

36 27.598 3.2296 85 2054 20.6 21762 27.8 0.180

37 27.762 3.2108 85 2922 29.3 28601 36.5 0.166

38 28.520 3.1272 85 843 8.5 5226 6.7 •0.105

39 28.862 3.0909 85 1652 16.6 13348 17.1 0.137

40 29.219 3.0540 85 600 6.0 8712 11.1 0.247

41 29.662 3.0093 85 3488 35.0 48456 61.9 0.236

42 29.858 2.9900 85 1934 19.4 37292 47.7 0.328

43 30.080 2.9684 85 830 8.3 15575 19.9 0.319

44 30.379 2.9399 85 490 4.9 5353 6.8 0.186

SCAN: 2.0/40.0/0.02/0.1 (sec), Cu, l(p)=10000, 02/05/16 11 : 12a

PEAK: 15(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

45 30.777 2.9028 85 2419 24.3 17572 22.5 0.124

46 31.001 2.8823 85 817 8.2 11227 14.3 0.234

47 31.260 2.8591 85 1231 12.4 13104 16.7 0.181

48 31.479 2.8396 85 1544 15.5 13371 17.1 0.147

49 31.937 2.7999 85 909 9.1 12362 15.8 0.231

50 32.439 2.7577 85 898 9.0 8322 10.6 0.158

51 32.840 2.7250 85 531 5.3 6016 7.7 0.193

52 33.222 2.6945 85 520 5.2 7051 9.0 0.230

53 33.420 2.6791 100 546 5.5 4272 5.5 0.133

54 33.880 2.6437 100 927 9.3 18600 23.8 0.341

55 34.083 2.6284 100 2063 20.7 17666 22.6 0.146

56 34.640 2.5874 102 379 3.8 4042 5.2 0.181

57 35.062 2.5572 87 2365 23.7 21954 28.1 0.158

58 35.642 2.5169 68 884 8.9 5669 7.2 0.109

59 36.101 2.4860 68 211 2.1 11 17 1.4 0.090

60 36.342 2.4700 68 329 3.3 5650 7.2 0.292

61 36.879 2.4353 79 484 4.9 8151 10.4 0.286

62 37.140 2.4188 88 2015 20.2 30446 38.9 0.257

63 38.262 2.3504 88 793 8.0 9301 1 1.9 0.199

64 38.617 2.3296 88 573 5.7 6454 8.2 0.192

65 38.782 2.3201 108 407 4.1 15742 20.1 0.658

66 39.201 2.2963 108 1616 16.2 25916 33.1 0.273

67 39.640 2.2718 108 995 10.0 11361 14.5 0.194

Example 16 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide bis-methanol solvate: X-ray quality crystals were grown from a saturated, heated methanol solution of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide followed by the slow cooling and evaporation of the solvent overnight and allowing the super saturated solution to stand for 2 months to give colorless plates.

A colorless plate 0.060 χ 0.040 χ 0.020 mm in size was mounted on a Cryoloop with Paratone oil. Data were collected in a nitrogen gas stream at 100(2) K using phi and omega scans. Crystal-to-detector distance was 60 mm and exposure time was 10 seconds per frame using a scan width of 1.0°. Data collection was 100.0% complete to 25.000° in q. A total of 39,817 reflections were collected covering the indices, -1 l<=h<=l 1, -15<=£<=15, -21<=/<=21. 14799 reflections were found to be symmetry independent, with an Rint of 0.0383. Indexing and unit cell refinement indicated a primitive, triclinic lattice. The space group was found to be P 1 (No. 1). The data were integrated using the Bruker SAINT software program and scaled using the SADABS software program. Solution by iterative methods (SHELXT) produced a complete heavy-atom phasing model consistent with the proposed structure. All non-hydrogen atoms were refined anisotropically by full-matrix least-squares (SHELXL-2014). All hydrogen atoms were placed using a riding model. Their positions were

constrained relative to their parent atom using the appropriate HFIX command in SHELXL-2014. Absolute stereochemistry was unambiguously determined to be R at C I 5, C31, C47, and C63, respectively. The crystal structure of the asymmetric unit for the bis-methanol solvate along the crystallographic b axis is shown in Figure 28.

The XRPD of the bis-methanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, as calculated from the SCXRD data at 100 K, is shown in Figure 30 and summarized in Table 30 below.

Table 30

XRPD Figure 29: Peaks of > 30% relative height at about 10.1, 13.9, 14.7,

18.7, 20.1, 20.6, 21.6, 21.8, 22.2, 22.4, 23.4, and 30.8 °2Θ.

Certain calculated XRPD diffraction peaks for the bis-methanol solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 31 below.

Table 31

SCAN: 2.0/40.0/0.02/0.1 (sec), Cu, l(p)=10000, 02/16/16 09:58a

PEAK: 15(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWH

1 7.683 1 1.4979 7 2372 23.8 17496 18.8 0.125

2 10.119 8.7342 31 9969 100.0 92690 99.5 0.158

3 1 .259 7.8526 31 1036 10.4 6116 6.6 0.100

4 13.018 6.7953 39 372 3.7 211 1 2.3 0.096

5 13.902 6.3648 65 3284 32.9 26858 28.8 0.139

6 14.682 6.0285 63 3837 38.5 40955 43.9 0.181

7 15.403 5.7478 26 636 6.4 5053 5.4 0.135

8 16.781 5.2788 26 2038 20.4 18785 20.2 0.157

9 17.041 5.1989 27 1438 14.4 15701 16.8 0.186

10 18.461 4.8023 44 1991 20.0 22827 24.5 0.195

1 1 18.697 4.7421 63 6269 62.9 45796 49.1 0.124

12 18.899 4.6918 72 1292 13.0 32234 34.6 0.424

13 19.460 4.5579 72 1012 10.1 9151 9.8 0.154

14 20.142 4.4050 197 6728 67.5 51107 54.8 0.129

15 20.321 4.3666 204 2615 26.2 31856 34.2 0.207

16 20.580 4.3123 214 3350 33.6 ' 23467 25.2 0.119

17 21.281 4.1717 228 ' 2702 27.1 46637 50.0 0.293

18 21.561 4.1183 228 7755 77.8 93202 100.0 0.204

19 21.819 4.0701 228 3497 35.1 73763 79.1 0.359

20 22.222 3.9972 228 6561 65.8 52318 56.1 0.136

21 22.460 3.9554 228 8692 87.2 77673 83.3 0.152

22 23.202 3.8306 143 2207 22.1 32991 35.4 0.254

23 23.359 3.8051 143 3085 30.9 30407 32.6 0.168

24 23.639 3.7606 143 2070 20.8 17990 19.3 0.148

25 24.159 3.6809 142 751 7.5 4274 4.6 0.097

26 24.663 3.6068 140 1438 14.4 10531 1 1.3 0.125

27 24.940 3.5674 139 665 6.7 ' 4693 5.0 0.120

28 25.419 3.5012 138 823 8.3 4821 5.2 0.100

29 25.820 3.4477 138 2207 22.1 . 21569 23.1 0.166

30 26.182 3.4009 138 2546 25.5 2511 1 26.9 0.168

31 26.599 3.3485 138 902 9.0 9483 10.2 0.179

32 26.821 3.3213 138 2159 21.7 16220 17.4 0.128

33 27.222 3.2733 112 1058 10.6 8151 8.7 0.131

34 27.378 3.2550 112 584 5.9 7189 7.7 0.209

35 27.720 3.2156 112 1202 12.1 7229 7.8 0.102

36 28.421 3.1379 112 950 9.5 12173 13.1 0.218

37 28.581 3.1206 112 1805 18.1 26783 28.7 0.252

38 28.861 3.0910 112 450 4.5 10698 11.5 0.404

39 29.259 3.0498 112 1676 16.8 13308 14.3 0.135

40 29.741 3.0016 144 481 4.8 5532 5.9 0.196

41 30.419 2.9361 125 1779 17.8 34567 37.1 0.330

42 30.800 2.9007 125 3394 34.0 56300 60.4 0.282

43 31.201 2.8643 125 1522 15.3 18172 19.5 0.203

44 31.683 2.8218 125 2983 29.9 25452 27.3 0.145

SCAN: 2.0/40.0/0.02/0.1 (sec), Cu, l(p)=10000, 02/16/16 09:58a

PEAK: 15(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

45 32.178 2.7795 125 802 8.0 7982 8.6 0.169

46 32.622 2.7427 125 943 9.5 8138 8.7 0.147

47 33.097 2.7045 196 357 3.6 5065 5.4 0.241

48 33.301 2.6883 195 225 2.3 1819 2.0 0.137

49 33.643 2.6618 210 425 4.3 1684 1.8 0.067

50 33.920 2.6406. 102 384 3.9 4371 4.7 0.194

51 34.180 2.6212 102 1 1 16 11 .2 7906 8.5 0.120

52 34.483 2.5988 102 976 9.8 9291 10.0 0.162

53 35.161 2.5503 102 457 4.6 2580 2.8 0.096 .

54 35.700 2.5130 102 1 175 11 .8 17948 19.3 0.260

55 35.938 2.4969 102 1071 10.7 1 1373 12.2 0.180

56 36.321 2.4714 102 1077 10.8 10553 1 1.3 0.167

57 37.019 2.4264 88 1583 15.9 19451 20.9 0.209

58 37.401 2.4025 88 484 4.9 851 1 9.1 0.299

59 38.200 2.3541 88 393 3.9 3658 3.9 0.158

60 38.381 2.3434 88 352 3.5 3050 3.3 0.147

61 38.783 2.3200 93 1910 19.2 22138 23.8 0.197

62 39.259 2.2930 93 1672 16.8 24368 26.1 0.248

Example 17 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 - yl)cyclopropanecarboxamide methyl /ert-butyl ether solvate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5- bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was dissolve at 200 mg/mL in pyridine at 65 °C. The solution was diluted to 10 mg/mL with methyl /ert-butyl ether and cooled from 65 °C to 10 °C over 14.5 h. The mixture was evaporated until dry to yield (i?)-N-(4-(3- aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide methyl tert- butyl ether solvate. The physical properties of the methyl /ert-butyl ether solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 32 below.

Table 32


Certain XRPD diffraction peaks for the methyl fert-butyl ether solvate of the free base of (R)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 33 below.

Table 33

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=391.0, 09/21/11 10:42a

PEAK: 29(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.,0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

2-Theta d(A) BG Height H% Area A% FWH

1 8.092 10.9179 14 24 6.4 149 1.2 0.105

2 9.257 9.5457 15 24 6.4. 590 4.7 0.420

3 10.700 8.2614 17 374 100.0 5094 41.0 0.231

4 12.019 7.3578 ' 18 74 19.7 1335 10.7 0.307

5 12.421 7.1204 18 73 19.4 897 7.2 0.210

6 14.077 6.2863 17· 51 13.6 703 5.7 0.235

7 16.022 5.5272 19 108 28.7 2453 19.7 0.388

8 16.589 5.3395 19 28 7.4 163 1.3 0.101

9 18.620 4.7614 24 346 92.5 4890 39.3 0.240

10 19.219 4.6145 ' 38 333 89.0 11412 91.8 0.583

11 21.023 4.2224 31 208 55.6 6035 48.6 0.493

12 21.520 4.1260 37 275 73.6 12429 100.0 0.767

13 22.179 4.0048 37 136 36.5 1548 12.5 0.193

14 22.702 3.9137 38 60 16.0 1596 12.8 0.452

15 23.218 3.8278 38 158 42.2 3401 27.4 0.366

16 24.238 3.6690 37 71 19.1 1053 8.5 0.251

17 25.338 3.5122 36 85 22.7 1394 1 1.2 0.279

18 26.938 3.3071 39 - 65 17.4 1558 12.5 0.407

19 27.840 3.2020 36 58 15.4 987 7.9 0.292

20 28.181 3.1640 36 83 22.1 1270 10.2 0.262

21 28.622 3.1 163 38 106 28.4 3296 26.5 0.526

22 29.620 3.0135 44 124 33.2 1757 14.1 0.240

23 30.683 2.9115 45 - 39 10.4 470 3.8 0.205

24 31.320 2.8537 51 56 14.8 2833 22.8 0.868

25 31.758 2.8153 63 83 22.1 2226 17.9 0.459

26 32.621 2.7428 55 60 16.2 795 6.4 0.224

27 34.298 2.6124 31 25 6.6 347 2.8 0.240

28 35.304 2.5402 35 32 8.6 566 4.6 0.299

29 35.839 2.5035 37 31 8.4 897 7.2 0.485

30 37.345 2.4060 42 67 18.0 1778 14.3 0.449

31 39.459 2.2818 49 46 12.2 939 7.6 0.350

Example 18 (R)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide toluene solvate.

Method A: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (26.4 mg) was heated in toluene (5 raL) at 50°C in a shaker block for 22 days. The sample was cooled to ambient and the solid removed and analyzed by XRPD while still damp with solvent.

Method B : (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 - yl)cyclopropanecarboxamide (28.8 mg) was slurried in toluene (5 mL) at 25°C in a shaker block for 24 days. The solid was removed and analyzed by XRPD while still damp with solvent.

Method C: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide was dissolved at 10 mg/mL in toluene at 65 °C. The solution was cooled from 65 °C to 10 °C over 14.5 h, then held at 5 °C until crystals formed. Solids were isolated via filtration to yield (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide toluene solvate.

The physical properties of the toluene solvate of the free base of (i?)-N-(4-(3-aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 34 below.

Table 34


Certain XRPD diffraction peaks for the toluene solvate of the free base of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 35 below.

Table 35

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=778.0, 11/12/12 02:43p

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1 ,0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWH

1 9.302 9.5000 13 99 13.0 1451 13.0 0.250

2 9.603 9.2023 13 144 18.9 1514 13.6 0.179

3 12.062 7.3312 12 239 31.4 2962 26.5 0.211

4 12.619 7.0090 13 88 11.6 1186 10.6 0.229

5 14.818 5.9737 18 114 15.0 1483 13.3 0.222

6 15.961 5.5483 19 225 29.6 3111 27.9 0.235

7 18.742 4.7306 19 137 18.1 2109 18.9 0.261

8 19.381 4.5763 19 759 100.0 11168 100.0 0.250

9 19.841 4.4711 19 460 60.6 7237 64.8 0.267

10 20.299 4.3713 19 38 5.1 908 8.1 0.402

11 21.619 4.1072 33 293 38.6 5096 45.6 0.296

12 21.860 4.0626 32 166 21.8 3411 30.5 0.350

13 22.719 3.9109 34 78 10.2 1338 12.0 0.293

14 23.318 3.8117 34 506 66.7 7880 70.6 0.265

15 24.320 3.6569 29 156 20.5 2135 19.1 0.233

16 25.399 3.5039 26 89 11.7 1051 9.4 0.202

17 26.259 3.391 1 31 55 7.2 653 5.8 0.202

18 26.940 3.3069 33 122 16.0 2093 18.7 0.293

19 28.083 3.1748 30 69 9.1 1 129 10.1 0.277

20 28.883 3.0887 35 124 16.4 2618 23.4 0.358

21 29.259 3.0499 52 196 25.8 3557 31.8 0.308

22 29.616 3.0139 33 74 9.7 3454 30.9 0.795

23 29.993 2.9769 33 40 5.2 535 4.8 0.228

24 30.819 2.8990 36 124 16.4 2055 18.4 0.281

25 32.139 2.7828 43 176 23:2 3535 31.6 0.341

26 32.797 2.7285 31 48 6.4 1072 9.6 0.376

27 33.021 2.7105 31 38 5.1 326 2.9 0.144

28 34.603 2.5901 29 25 3.2 434 3.9 0.300

29 35.838 2.5036 29 51 6.7 1247 11.2 0.417

30 36.176 2.4810 31 54 7.1 1247 11.2 0.391.

31 37.222 2.4136 36 74 9.8 1282 11.5 0.294

32 38.458 2.3389 42 44 5.8 819 7.3 0.314

Example 19 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide butyronitrile solvate: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was dissolved at 500 mg/mL in 2,2,2-trifluoroethanol at 65 °C. The solution was diluted to 25 mg/mL with butyronitrile and cooled from 65 °C to 10 °C over 14.5 h. Solids were isolated via filtration to yield (i?)-N-(4-(3 -aminopiperidin- 1-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide butyronitrile solvate. The physical properties of the butyronitrile solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 36 below.

Table 36

XRPD Figure 34: Peaks of > 40% relative height at about 9.8, 15.7, 17.1, 19.4,

19.9, 21.3, 21.6, 22.2, 23.2, 23.4, 25.1, and 47.9 °2Θ.

DSC Figure 35 : Endotherm with extrapolated onset temperature about 100

°C and enthalpy of fusion about 75 J/g. Endotherm with extrapolated onset temperature about 267 °C and enthalpy of fusion about 92 J/g.

TGA Figure 35 : About 8.5% weight loss up to about 120 °C.

Certain XRPD diffraction peaks for the butyronitrile solvate of the free base of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 37 below.

Table 37

SCAN: 2.0/40.0/0.02/0.6(sec), Cu(30kV,15mA), l(p)=336.0, 09/20/11 05:02p

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 8.496 10.3991 21 88 31.2 867 16.5 0.167

2 9.242 9.561 1 23 29 10.2 949 1 B.1 0.559

3 9.840 8.9816 19 160 56.6 2402 45.7 0.256

4 12.001 7.3687 23 51 18.2 844 16.1 0.280

5 12.440 7.1095 23 71 25.3 838 16.0 0.200

6 14.677 6.0306 24 31 11.0 361 6.9 0.198

7 15.681 5.6466 32 260 92.0 2847 54.2 0.186

8 17.141 5.1688 37 137 48.5 1362 25.9 0.169

9 18.550 4.7793 37 55 19.4 671 12.8 0.208

10 18.901 4.6914 46 89 31.4 1540 29.3 0.295

11 19.358 4.5817 58 134 47.4 2791 53.1 0.355 .

12 19.879 4.4626 54 282 100.0 5253 100.0 0.316

13 21.257 4.1764 54 189 67.1 3225 61.4 0.290

14 21.558 4.1188 61 .169 59.9 5075 96.6 0.510

15 21.840 4.0661 69 112 39.6 2629 50.1 0.400

16 22.176 4.0054 67 156 55.3 1253 23.8 0.136

17 23.218 3.8279 70 130 46.2 3182 60.6 0.415

18 23.420 3.7954 66 155 54.9 3630. 69.1 0.398

19 24.877 3.5762 59 109 38.6 1542 29.4 0.241

20 25.101 3.5449 58 131 46.3 1584 30.1 0.206

21 25.916 3.4352 53 82 29.1 1257 23.9 0.260

22 26.878 3.3144 55 97 34.5 1739 33.1 0.304

23 27.299 3.2642 54 61 21.6 1367 26.0 0.380

24 28.360 3.1445 58 33 11.8 414 7.9 0.21 1

25 29.220 3.0538 61 29 10.2 579 11.0 0.343

26 29.796 2.9961 69 31 11.0 321 6.1 0.176

27 30.701 2.9098 67 46 16.3 380 7.2 0.140

28 3 .364 2.8498 67 53 18.8 1415 26.9 0.452

29 31.705 2.8199 60 60 21.2 2242 42.7 0.638

30 32.118 2.7846 55 55 19.5 2379 45.3 0.735

31 33.740 2.6544 55 46 16.2 549 10.4 0.204

32 34.736 2.5805 55 65 23.2 532 10.1 0.138

33 36.083 2.4872 48 40 14.2 1559 29.7 0.661

34 37.424 2.4011 56 39 14.0 268 5.1 0.115

35 38.140 2.3577 57 135 47.9 1884 35.9 0.237

36 38.640 2.3283 60 39 14.0 617 11.7 0.266

Example 20 (R)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2.3-b]pyridin-3-yl)cyclopropanecarboxamide di -methanesulfonic acid salt hydrate.

Method A: (R)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (40 mg, 0.11 mmol) was suspended in about 1 mL of acetone.

Methanesulfonic acid (0.22 mmol, 20.3 mg) was added and the resulting suspension stirred for one day. The solids were isolated by centrifugation.

Method B: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (40 mg, 0.11 mmol) was dissolved in about 1 mL of tetrahydrofuran.

Methanesulfonic acid (0.22 mmol, 20.3 mg) was added and the resulting suspension stirred for one day. The solids were isolated by centrifugation.

The physical properties of the hydrate of the di-mesylate salt of (i?)-N-(4-(3-aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 38 below.

Table 38


Certain XRPD diffraction peaks for the hydrate of the di-mesylate salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 39 below.

Table 39

SCAN: 4.0/40.0055/0.01975/21.6(sec), Cu(40kV,40mA), l(p)=26838, 09/08/13 05:40p

PEAK: 19(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 4.435 19.9098 1024 25814 100.0 340263 100.0 0.221

2 6.232 14.1708 921 1630 6.3 14494 4.3 0.149

3 6.666 13.2489 883 3759 14.6 58061 17.1 0.259

4 8.541 10.3441 810 2387 9.2 20384 6.0 0.143

5 8.916 9.9106 829 236 0.9 2550 0.7 0.182

6 12.021 7.3563 1226 819 3.2 6353 1.9 0.130

7 12.492 7.0802 1358 239 0.9 1959 0.6 0.137

8 14.488 6.1089 1649 1564 6.1 27687 8.1 0.297

9 15.696 5.6414 1540 913 3.5 8066 2.4 0.148

10 17.349 5.1073 1205 705 2.7 7104 2.1 0.169

11 17.868 4.9602 1123 939 3.6 11325 3.3 0.202

12 18.317 4.8395 1037 1175 4.6 9978 2.9 0.143

13 18.897 4.6924 966 859 3.3 10263 3.0 0.200 .

14 19.225 4.6129 944 729 2.8 7890 2.3 0.182

15 19.958 4.4452 877 961 3.7 7303 2.1 0.128

16 20.628 4.3023 885 3999 15.5 39012 11.5 0.164

17 21 .462 4.1370 857 2418 9.4 35879 10.5 0.249

18 22.409 3.9642 796 731 2.8 26557 7.8 0.610

19 22.899 3.8804 793 1862 7.2 38499 11.3 0.347

20 23.868 3.7251 793 2524 9.8 45137 13.3 0.300

21 24.266 3.6650 748 919 3.6 20859 6.1 0.381

22 24.637 3.6106 658 833 3.2 13491 4.0 0.272

23 25.270 3.5215 681 1805 7.0 15904 4.7 0.148

24 25.846 3.4443 611 1075 4.2 9921 2.9 0.155

25 26.220 3.3960 561 518 2.0 5560 1.6 0.180

26 27.088 3.2892 541 668 2.6 5678 1.7 0.143

27 27.621 3.2269 589 273 1.1 4261 1.3 0.262

28 27.939 3.1909 575 1720 6.7 23567 6.9 0.230

29 29.182 3.0578 603 438 1.7 7751 2.3 0.297

30 29.975 2.9786 564 122 0.5 1078 0.3 0.148

31 30.504 2.9282 532 361 1.4 6266 1.8 0.291

32 31.197 2.8646 514 197 0.8 1649 0.5 0.140

33 31.908 2.8024 490 321 1.2 7424 2.2 0.388

34 32.279 2.7710 480 368 1.4 4902 1.4 0.224

35 33.329 2.6861 457 603 2.3 9548 2.8 0.266

36 33.958 2.6378 457 193 0.7 2424 0.7 0.211

37 34.614 2.5893 457 209 0.8 5124 1.5 0.412

38 35.225 2.5458. 486 368 1.4 10668 3.1 0.487

39 35.839 2.5036 511 188 0.7 3531 1.0 0.315

40 36.312 2.4720 469 276 1.1 8435 2.5 0.512

41 36.866 2.4362 497 159 0.6 2224 0.7 0.235

42 38.009 2.3655 458 257 1.0 2647 0.8 0.173

43 39.099 2.3020 453 181 0.7 1846 0.5 0.171

Example 21 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate.

Method A: (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide (40 mg, 0.1 1 mmol) was dissolved in about 1 mL of tetrahydrofuran. Ethanesulfonic acid (0.22 mmol, 24.5 mg) was added and the resulting suspension stirred for one day. The solids were isolated by centrifugation.

Method B: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide (40 mg, 0.1 1 mmol) was suspended in about 1 mL of acetone.

Ethanesulfonic acid (0.22 mmol, 24.5 mg) was added and the resulting suspension stirred for one day. The solids were isolated by centrifugation.

The physical properties of the hydrate of the di-esylate salt of (i?)-N-(4-(3-aminopiperidin-l - yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 40 below.

Table 40


Certain XRPD diffraction peaks for the of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 41 below.

Table 41

SCAN: 4.0/40.0055/0.0 975/21.6(sec), Cu(40kV,40mA), l(p)=11324, 09/08/13 05:40p

PEAK: 19(pts)/Paraboiic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWH

1 4.514 19.5616 914 10410 100.0 167672 100.0 0.270

2 6.211 14.2195 736 2294 22.0 22548 13.4 0.165

3 6.746 13.0930 698 1761 16.9 34370 20.5 0.328

4 8.622 10.2473 654 627 6.0 8284 4.9 0.222

5 9.010 9.8065 658 137 1.3 1695 1.0 0.207

6 11.684 7.5680 932 201 1.9 1722 1.0 0.144

7 12.335 7.1697 1077 282 2.7 4733 2.8 0.282

8 14.151 6.2534 1408 397 3.8 8856 5.3 0.374

9 14.492 6.1072 1469 312 3.0 5288 3.2 0.284

10 16.799 5.2732 1192 606 5.8 5943 3.5 0.165

11 17.785 4.9831 1076 711 6.8 6147 3.7 0.145

12 18.518 4.7874 1037 862 8.3 12719 7.6 0.248

13 18.772 4.7233 984 403 3.9 13963 8.3 0.581

14 19.205 4.6178 984 230 2.2 3208 1.9 0.234

15 19.528 4.5421 964 332 3.2 3466 2.1 0.176

16 21.185 4.1905 810 628 6.0 15192 9.1 0.406

17 21.638 4.1038 834 1141 11.0 17589 10.5 0.259

18 22.588 3.9333 839 490 4.7 7497 4.5 0.257

19 22.975 3.8679 860 360 3.5 7248 4.3 0.338

20 23.496 3.7832 867 642 6.2 5928 3.5 0.155

21 23.989 3.7066 847 583 5.6 6870 4.1 0.198

22 24.561 3.6215 723 461 4.4 5415 3.2 0.197

23 25.484 3.4924 617 1 6 1.7 1833 1.1 0.174

24 25.843 3.4447 585 211 2.0 3940 2.3 0.313

25 26.375 3.3765 575 409 3.9 4348 2.6 0.178

26 26.972 3.3030 569 141 1.4 1036 0.6 0.123

27 27.721 3.2154 595 575 5.5 7815 4.7 0.228

28 28.432 3.1366 622 130 1.3 2170 1.3 0.280

29 28.965 3.0802 600 478 4.6 9430 5.6 0.331

30 30.306 2.9468 539 184 1.8 1499 0.9 0.137

31 31.077 2.8755 511 251 2.4 4379 2.6 0.293

32 31.471 2.8404 513 192 1.8 3762 2.2 0.328

33 31.789 2.8126 524 113 1.1 1308 0.8 0.194

34 32.495 2.7532 542 210 2.0 2217 1.3 0.178

35 33.212 2.6953 526 197 1.9 4634 2.8 0.395

36 33.642 2.6619 489 97 0.9 2297 1.4 0.397

37 34.238 2.6168 474 99 1.0 2432 1.5 0.41 1

38 34.755 2.5791 478 160 1.5 3467 2.1 0.364

39 35.485 2.5277 473 169 1.6 4029 2.4 0.400

40 35.838 2.5036 456 113 1.1 4601 2.7 0.686

41 37.492 2.3969 447 84 0.8 1348 0.8 0.269

Example 22 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-methanesulfonic acid salt: Approximately 5.0 g of ( ?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was weighed into a 500 mL of round-bottom flask, and then approximately 250 mL of acetone was added. 1.0 equivalents of methanesulfonic acid was slowly titrated into the reaction bulb. The suspension was kept stirring on a magnetic stirrer at room temperature. After 24 hrs, the remaining solid was separated by vacuum filtration. The wet cake was dried under reduced pressure at 35 °C overnight. The physical properties of the non-solvated mono-mesylate salt of (i?)-N-(4-(3-aminopiperidin-l-yl)- 5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 42 below.

Table 42


Certain XRPD diffraction peaks for the non-solvated mono-mesylate salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown ' Table 43 below.

Table 43

SCAN: 4.0/40.0087/0.0 972/18.6(sec), Cu(40kV,40mA), l(p)=2002, 09/11/14 11 :24p

PEAK: 27(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1)

# 2-Theta d(A) BG Height H% Area A% FWHM

1 8.654 10.2098 186 776 44.2 13180 48.7 0.285

2 8.988 9.8305 172 567 32.3 12995 48.0 0.384

3 12.124 7.2939 167 518 29.5 7254 26.8 0.235

4. 14.313 6.1829 158 479 27.3 6889 25.5 0.241

5 15.773 5.6140 162 437 24.9 5981 22.1 0.229

6 17.037 5.2002 174 109 6.2 21 19 7.8 0.325

7 17.960 4.9348 202 216 12.3 2694 10.0 0.209

8 19.046 4.6559 230 1034 58.9 27057 100.0 0.438

9 19.892 4.4597 238 153 8.7 2229 8.2 0.244

10 20.565 4.3154 246 894 50.9 16212 59.9 0.304

1 1 21.571 4.1163 246 1756 100.0 24154 89.3 0.231

12 22.260 3.9905 236 95 5.4 1174 4.3 0.207

13 22.656 3.9216 217 298 17.0 5881 21.7 0.330

14 23.166 3.8364 237 78 4.4 340 1.3 0.073

15 24.725 3.5978 175 571 32.5 15604 57.7 0.458

16 25.394 3.5046 197 154 8.7 2404 8.9 0.262

17 26.699 3.3361 167 268 15.3 8017 29.6 0.501

18 27.623 3.2267 165 266 15.1 4593 17.0 0.289

19 28.056 3.1778 165 78 4.4 1070 4.0 0.230

20 28.826 3.0947 59 75 4.3 949 3.5 0.212

21 29.559 3.0196 157 93 5.3 1439 5.3 0,260

22 29.949 2.9811 151 82 4.7 1178 4.4 0.241

23 30.958 2.8863 150 160 9.1 6850 25.3 0.719

24 31.648 2.8248 159 124 7.1 8032 29.7 1.084

25 32.102 2.7860 150 139 7.9 2200 8.1 0.266

26 32.929 2.7179 148 150 8.5 2834 10.5 0.317

27 34.136 2.6244 150 96 5.4 1110 4.1 0.195

28 35.336 . 2.5381 174 126 7.2 1549 5.7 0.205

29 36.027 2.4909 165 124 7.1 2513 9.3 0.339

30 37.174 2.4166 150 85 4.8 1424 5.3 0.280

31 38.040 2.3636 148 63 3.6 712 2.6 0.190

32 38.924 2.3119 142 46 2.6 2074 7.7 0.757

33 39.360 2.2873 137 B9 5.1 2074 7.7 0.392

Example 23 (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono -ethane sulfonic acid salt: Approximately 10 g of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was weighed into a 500 mL round-bottom flask, and then approximately 500 mL of acetone was added. 1.0 equivalents of ethanesulfonic acid was slowly titrated into the sample. The suspension was kept stirring on a magnetic stirrer at room temperature. After 24 hrs, the remaining solid was isolated by vacuum filtering. After that, the wet cake was suspended with 180 mL acetone for purification. The purified solid samples were isolated by vacuum filtering and dried under reduced pressure at room temperature. The physical properties of the non-solvated mono-esylate salt of (i?)-N-(4-(3-

aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 44 below.

Table 44


Certain XRPD diffraction peaks for the non-solvated mono-esylate salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 45 below.

Table 45

SCAN: 4.0/40.0 02/0.01973/18.6(sec), Cu(40kV,40mA), l(p)=3055, 1 1/28/13 12:26a

PEAK: 23(pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 8.677 10.1827 206 835 30.6 16425 33.5 0.330

2 9.074 9.7383 201 771 28.2 11030 22.5 0.240

3 12.050 7.3389 186 679 24.9 8943 18.2 0.221

4 14.377 6.1559 195 936 34.3 11306 23.0 0.203

5 15.660 5.6542 199 749 27.4 9346 19.0 0.209

6 16.743 5.2908 198 158 5.8 2278 4.6 0.241

7 7.203 5.1503 205 174 6.4 2423 4.9 0.233

8 18.028 4.9164 212 463 17.0 4943 10.1 0.179

9 18.443 4.8069 249 293 10.7 9172 18.7 0.524

10 18.957 4.6775 249 2345 85.9 49093 100.0 0.351

11 19.883 4.46 8 249 236 8.7 2266 4.6 0.161

12 20.398 4.3504 324 1066 39.0 7646 35.9 0.278

13 21.325 4.1633 323 2732 100.0 34862 71.0 0.214

14 22.546 3.9404 254 550 20.1 7406 15.1 0.226

15 23.281 3.8177 237 256 9.4 2976 6.1 0.195

16 24.046 3.6980 256 156 5.7 1716 3.5 0.184

17 24.837 3.5820 250 805 29.5 19930 40.6 0.415

18 25.310 3.5160 237 277 10.1 4634 9.4 0.281

19 26.416 3.3713 252 823 30.1 16123 32.8 0.328

20 27.226 3.2728 263 83 3.0 1505 3.1 0.304

21 27.678 3.2203 238 298 10.9 5718 11.6 0.322

22 28.724 3.1054 200 173 6.3 2684 5.5 0.261

23 29.453 3.0302 201 120 4.4 2522 5.1 0.352

24 30.520 .2.9267 212 293 10.7 4356 8.9 0.249

25 30.893 2.8922 248 229 8.4 8266 16.8 0.606

26 31.388 2.8477 248 373 13.6 10107 20.6 0.455

27 31.882 2.8046 284 196 7.2 3215 6.5 0.275

28 32.438 2.7579 240 195 7.1 4840 9.9 0.416

29 34.050 2.6309 251 128 4.7 2007 4.1 0.262

30 34.723 2.5814 247 205 7.5 5423 1 1.0 0.443

31 35.096 2.5548 263 135 4.9 3384 6.9 0.421

32 35.726 2.5112 253 127 4.6 1 45 2.3 0.152

33 36.242 2.4766 248 319 1 1.7 5357 10.9 0.282

34 36.680 2.4481 236 1 17 4.3 1846 3.8 0.264

35 37.996 2.3662 243 187 6.8 4435 9.0 0.397 .

36 39.048 2.3049 228 73 2.7 1814 3.7 0.416

Example 24 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2.34o]pyridin-3-yl)cyclopropanecarboxamide di-benzenesulfonic acid salt.

Method A: Approximately 40 mg of ( ?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide was weighed into a 4 mL vial and suspended with suitable amount of THF, then 2 equivalents of benzene sulfonic acid was added. The mixture was stirred for 1 day.

Method B: (R)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide (40 mg) was weighed into a 4 mL centrifuge tube and added into 2 mL of THF to form a suspension. An appropriate amount of benzenesulfonic acid (39 mg, content 90%) was added into the suspension to keep the molar ratio of API: acid equal to 1 : 2.1. The suspension was mixed completely on a rotary shaker for 1 day at room temperature. The precipitation was centrifuged at 10,000 rpm for 3 minutes, and dried under reduced pressure for 1 day at room temperature.

The physical properties of the non-solvated di-besylate salt of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 46 below.

Table 46

XRPD Figure 46: Peaks of > 5% relative height at about 4.6, 6.8, 8.0, 9.6,

13.0, 14.9, 18.4, 19.3, 20.9, 21.3, 21.9, 25.6, and 27.2 °2Θ.

Certain XRPD diffraction peaks for the non-solvated di-besylate salt of (i?)-N-(4-(3-aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 47 below.

Table 47

SCAN: 4.0/39.9975/0.01975/21 ,6(sec), Cu(40kV,40mA), l(p)=12887, 09/10/13 05:02p

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1%, BG=3/1.0, Peak-Top=Summit

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1.54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 4,631 19.0640 992 11895 100.0 186126 100.0 0.263

2 6.843 12.9061 789 1639 13.8 24874 13.4 0.255

3 7.968 11.0866 747 4350 36.6 41038 22.0 0.158

4 9.193 9.6124 656 435 3.7 6144 3.3 0.237

5 9.587 9.2 76 655 1232 10.4 13993 7.5 0.191

6 13.040 6.7836 968 900 7.6 8108 4.4 0.151

7 13.532 6.5381 1038 283 2.4 2873 1.5 0.170

8 14.346 6.1688 1066 550 4.6 10814 5.8 0.330

9 14.923 5.9319 1055 679 5.7 13008 7.0 0.322

10 16.370 5.4107 1031 126 1.1 1528 0.8 0.203

1 1 16.696 5.3055 987 461 3.9 6064 3.3 0.221

12 17.038 5.2000 955 324 2.7 4015 2.2 0.208

13 18.376 4.8243 907 1090 9.2 12376 6.6 0.191

14 19.285 4.5989 986 1352 11.4 21425 11.5 0.266

15 20.231 4.3858 991 500 4.2 2760 1.5 0.093

16 20.899 4.2472 1060 658 5.5 4575 2.5 0.117

17 21.316 4.1650 992 1219 10.3 16320 8.8 0.225

18 21.909 4.0535 1006 1081 9.1 26070 14.0 0.405

19 22.603 3.9307 1008 · 331 2.8 3437 1.8 0.174

20 23.392 3.7999 946 480 4.0 4252 2.3 0.149

21 23.984 3.7073 870 583 4.9 14238 7.6 0.410

22 24.441 3.6391 891 134 1.1 2320 1.2 0.291

23 24.929 3.5689 841 511 4.3 4336 2.3 0.142

24 25.563 3.4819 778 801 6.7 12001 6.4 0.252

25 26.214 3.3969 759 526 4.4 10023 5.4 0.320

26 27.163 3.2802 773 1108 9.3 17128 9.2 0.259

27 27.459 3.2456 726 391 3.3 12046 6.5 0.517

28 28.149 3.1675 728 409 3.4 4000 2.1 0.164

29 28.902 3.0867 694 304 2.6 5259 2.8 0.290

30 29.650 3.0105 649 358 3.0 8965 4.8 0.421

.31 30.120 2.9646 662 252 2.1 4560 2.4 0.304

32 31.646 2.8250 584 209 1.8 4984 2.7 0.400

33 32.183 2.7792 556 137 1.2 3653 2.0 0.448

34 32.593 2.7451 581 145 1.2 1516 0.8 0.175

35 33.660 2.6605 536 185 1.6 4939 2.7 0.449

36 34.035 2.6320 519 304 2.6 9050 4.9 0.500

37 35.832 2.5041 486 117 1.0 2354 1.3 0.337

38 36.954 2.4305 473 129 1.1 3136 1.7 0.408

39 37.388 2.4033 476 162 1.4 3179 1.7 0.330

40 38.478 2.3377 479 197 1.7 4907 2.6 0.417

Example 25 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5-bromo- lH-pyrrolo[2,3-b]pyridin-3 -yl)cyclopropanecarboxamide di-toluenesulfonic acid salt.

Method A: Approximately 40 mg of ( ?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,34j]pyridin-3-yl)cyclopropanecarboxamide was weighed into a 4 mL vial and suspended

with suitable amount of acetone or THF, then 2 equivalents of toluenesulfonic acid was added and the mixture was stirred for 1 day.

Method B : (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 - yl)cyclopropanecarboxamide (40 mg) was weighed into a 4 mL centrifuge tube and added into 2 mL of IP A (isopropanol) to form a suspension. An appropriate amount of toluenesulfonic acid monohydrate (43 mg, content 99%) was added into the suspension to keep the molar ratio of API: acid equal to 1 : 2.1. The suspension was mixed completely on a rotary shaker for 1 day at room temperature. The precipitation were centrifuged at 10,000 rpm for 3 minutes, and dried under reduced pressure for 1 day at room temperature.

The physical properties of the non-solvated di-tosylate salt of (i?)-N-(4-(3 -aminopiperidin- 1- yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 48 below.

Table 48


Certain XRPD diffraction peaks for the non-solvated di-tosylate salt of (i?)-N-(4-(3- aminopiperidin-l -yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are shown in Table 49 below.

Table 49

SCAN: 4.0/39.9975/0.01975/21 ,6(sec), Cu(40kV,40mA), l(p)=17690, 09/10/13 05:02p

PEAK: 21 (pts)/Parabolic Filter, Threshold=3.0, Cutoff=0.1 %, BG=3/1.0, Peak-Top=Summlt

NOTE: Intensity = Counts, 2T(0)=0.0(deg), Wavelength to Compute d-Spacing = 1 .54059A (Cu/K-alpha1 )

# 2-Theta d(A) BG Height H% Area A% FWHM

1 4.533 19.4790 886 16804 100.0 279482 100.0 0.279

2 6.746 13.0921 756 2740 16.3 71478 25.6 0.438

3 7.139 12.3721 747 5314 31.6 64806 23.2 0.205

4 8.246 10.7132 714 226 1.3 1568 0.6 0.1 16

5 9.352 9.4492 699 1560 9.3 21039 7.5 0.226

6 9.645 9.1626 710 641 3.8 6977 2.5 0.183

7 12.609 7.0148 1042 1113 6.6 14355 5.1 0.216

8 13.616 6.4983 1217 602 3.6 8832 3.2 0.246

9 14.214 6.2258 1220 476 2.8 7468 2.7 0.263

10 14.882 5.9478 1223 685 4.1 9425 3.4 0.231

11 16.461 5.3808 1103 411 2.4 3980 1.4 0.163

12 16.792 5.2754 1069 579 3.4 5092 1.8 0.148

13 17.598 5.0356 1017 167 1.0 758 0.3 0.076

14 18.179 4.8761 1038 353 2.1 6059 2.2 0.288

15 18.631 4.7587 1108 832 4.9 13744 4.9 0.277

16 19.265 4.6034 1108 951 5.7 10741 3.8 0.190

17 19.638 4.5168 1021 507 3.0 4543 1.6 0.150

18 20.427 4.3441 989 1637 9.7 20628 7.4 0.212

19 21.121 4.2030 1016 606 3.6 12612 4.5 0.350

20 21.636 4.1042 889 1755 10.4 36261 13.0 0.347

21 22.224 3.9968 889 287 1.7 1714 0.6 0.100

22 23.214 3.8286 899 621 3.7 9548 3.4 0.258

23 23.568 3.7718 853 658 3.9 11310 4.0 0.289

24 23.962 3.7106 859 372 2.2 8546 3.1 0.386

25 24.537 3.6250 895 63 1.0 1222 0.4 0.126

26 25.246 3.5249 848 407 2.4 5619 2.0 0.232

27 25.857 3.4428 779 1484 8.8 22642 8.1 0.256

28 26.704 3.3355 785 180 1.1 1699 0.6 0.159

29 27.021 3.2972 737 345 2.1 11718 4.2 0.571

30 27.301 3.2639 698 521 3.1 18187 6.5 0.586

31 27.657 3.2228 698 314 1.9 4301 1.5 0.230

32 28.625 3.1159 648 325 1.9 6310 2.3 0.326

33 29.020 3.0744 654 188 1.1 7215 2.6 0.644

34 29.712 3.0044 658 361 2.2 4547 1.6 0.21 1

35 30.204 2.9565 622 11 1 0.7 3010 1.1 0.454

36 30.793 2.9013 630 220 1.3 2516 0.9 0.192

37 31.704 2.8200 585 211 1.3 3290 1.2 0.261

38 32.573 2.7468 571 126 0.7 4095 1.5 0.546

39 32.985 2.7133 549 155 0.9 4095 1.5 0.444

40 34.349 2.6087 543 101 0.6 61 10 2.2 1.012

41 34.790 2.5766 566 111 0.7 2264 0.8 0.344

42 36.129 2.4841 497 80 0.5 2551 0.9 0.536

43 38.358 2.3447 492 195 1.2 4681 1.7 0.403

Example 26 (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide di-ethanesulfonic acid salt: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide di-ethanesulfonic acid salt hydrate was

heated to 130 °C in a DSC apparatus and then cooled to room temperature. The anhydrate re-absorbs water at 80% RH and is converted to anhydrate. The physical properties of the non-solvated di-esylate salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide are summarized in Table 50 below.

Table 50


Example 27 Maleic acid salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide: Prepared by methods similar to those disclosed herein. The physical properties of the non-solvated mono-maleate salt of (i?)-N-(4-(3-aminopiperidin- l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 51 below.

Table 51


Example 28 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide HBr salt methanol solvate: Prepared by methods similar to those disclosed herein. The physical properties of the methanol solvate of the HBr salt of (i?)-N-(4-(3- aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 52 below.

Table 52

DSC/TGA Onset of desolvation at approximately 112 °C.

Example 29 (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3- yl)cyclopropanecarboxamide di-HCl salt: Prepared by methods similar to those disclosed herein. The physical properties of the non-solvated di-HCl salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH- pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 53 below.

Table 53

DSC/TGA Single endotherm due to melting/decomposition at -209 °C. -7%

weight loss by TGA, which occurs upon melting.

DVS Non-hygroscopic below 80% RH. Converts to a crystalline dihydrate form above 80% RH.

Example 30 (i?)-N-(4-(3-aminopiperidin-l-vl)-5-bromo-lH-pvrrolor2.3-blpvridin-3-yl)cyclopropanecarboxamide di-HBr salt: Prepared by methods similar to those disclosed herein. The physical properties of the non-solvated di-HBr salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide are summarized in Table 54 below.

Table 54

DSC/TGA Anhydrous solids with a concurrent melt/decomposition exotherm at

-273 °C. Analysis of the post-DVS solids shows -4% step-wise weight loss by TGA with an onset of desolvation at 81.2 °C. Further heating on the DSC shows the same exothermic behavior as the starting material however, the onset of the exotherm is at -217 °C.

DVS Non-hygroscopic below 80% RH. Upon desorption the solids were found to convert to a new mono-hydrate crystal form.

Example 31 Crystalline forms of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide salts with tartaric, succinic, and phosphoric acids, and solvates thereof, were also prepared by methods similar to those disclosed herein (data not shown).

Example 32 Excipient compatibility study of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt: (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide mono-ethanesulfonic acid salt and excipients were weighed according to formulation of Composite 2 and Composite 4 with equivalent incremental addition and ground thoroughly in a mortar, respectively (Table 55). Composite blanks (same formulation without API) were placed as controls with the same process. Each of about 100 mg of composite blends was pressed to a tablet formulation (diameter 8 mm, thickness 1 mm) with manual sheeter under the pressure (4 MPa) for half a minute. The tablet was transferred into a 40 mL glass vial for the storage conditions (Table 56). The stability samples in the vials were capped and sealed with parafilm. The samples were placed at 30 °C (closed), 40 °C (closed) and 50 °C (closed) for 0 day, 1 month, 3 months, 6 months, 12 months and backup in

duplicate and monitored with physical appearance, impurities/degradants and recovery at each time point, respectively. The excipient blanks as controls were conducted in single.

Table 55


Table 56


Example 33 Chemical characteristics of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,34o]pyridin-3-yl)cyclopropanecarboxamide free base (Form A) and maleate salt crystal forms: The stability of the crystal forms described in Examples 4 and 27 was measured neat as well as in a Powder-in-Capsule (PiC) formulation. The stability as neat powder was measured over a period of 1-year for the free base and 3 -months for the maleate salt, under ambient (25 °C/60%RH) and accelerated (40 °C/75%RH) conditions. The free base was found to show very good stability with no chiral or achiral degradation observed under any condition for a period of 1-year. The maleate salt under the same conditions, after 3 -months on stability, was found to show very slight degradation under accelerated conditions. It should be noted that the maleate salt used in the neat powder stability study contained high levels (-9% wt./wt.) of residual tetrahydrofuran (THF). The PiC stability using 15 mg of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide in Size 0 hard gelatin capsules was carried out over a period of 2-months at 5 °C, ambient and accelerated conditions. Similar to the neat powder, the PiC formulation did not cause any significant physical or chemical degradation in the free base formulation and the maleate salt, containing no residual THF, was also found to be stable.

To further investigate the chemical properties of these crystal forms, an abbreviated excipient compatibility study was run at 50 °C with 20% H20 added. The excipients used in the study consisted of common diluents and disintegrants and the study was conducted over a period of 4 weeks. The free base was found to show significant degradation with lactose and Ac-Di-Sol® (croscarmellose sodium) whereas the maleate salt was found to show significant degradation with all excipients investigated. Notably, the maleate salt also showed the same degradant formation as the free base in lactose suggesting that the salt does not fully attenuate the presumed Maillard reaction. Overall, the free base Form A appears to be more stable with excipients than the maleate salt of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide.

Example 34 Biological characteristics of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide free base (Form A) and maleate salt crystal forms: The oral absorption of the crystal forms described in Examples 4 and 27 as PiC formulations was investigated in a preclinical pharmacokinetic study conducted in canines using a reduced Latin square crossover design at 3 mg/kg to compare the solid formulations to a solution of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide. The results of this study showed that the area under the curve (AUC) variability is consistent between (i?)-N-(4-(3 -aminopiperidin- 1 -yl)-5 -bromo- lH-pyrrolo [2,3 -b]pyridin-3 -yl)cyclopropanecarboxamide formulations (PiC vs. solution) and that the maximal concentration (Cmax) data suggest the maleate salt PiC is less variable, however high variability was observed throughout the study. Consistent terminal elimination phases as well as half-life (ti/2) values were observed between formulations and the time to maximum concentration (Tmax) values were consistent with the toxicokinetic values obtained in GLP toxicology studies. No trends observed by AUCM or t1/2 could be discerned for each of the three formulations. In addition, the median CmaX values were similar across all formulations. (See Figure 54). Overall, no significant differences in absorption were found between the freebase and maleate crystal forms of (i?)-N-(4-(3-aminopiperidin-l-yl)-5-bromo-lH-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide .

Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, the descriptions and examples should not be construed as limiting the scope of the invention. The disclosures of all patent and scientific literature cited herein are expressly incorporated in their entirety by reference.