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1. WO2021058597 - METHODS OF DETERMINING WHETHER A SUBJECT IS AT RISK OF DEVELOPING ARTERIAL PLAQUES


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2020/076617 ROSSIGNO19287MC
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
23 September 2020 24 September 2019
Applicant
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA...
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     G16H 50/30 (2018.01)i; C12Q 1/6883 (2018.01)i; C12Q 1/37 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     G16H; C12Q; G01N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, COMPENDEX, EMBASE, INSPEC, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
XIE WUXIANG ET AL, "Association between plasma PCSK9 levels and 10-year progression of carotid atherosclerosis beyond LDL-C: A cohort study", INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER, AMSTERDAM, NL,Vol. 215, 16 April 2016 (2016-04-16), page 293-298,
XP029542658
1-3,7-10
cited in the application
A
abstract
4-6
page 294, column 1, paragraph 2 - page 295, column 1, paragraph 1
page 295, column 2, paragraphs 2,3
page 296, column 1, paragraph 2
(2)
Y
WO 2014197752 A1 (REGENERON PHARMA [US]; SANOFI SA [FR]) 11 December 2014 (2014-12-11)
1-3,7-10
A
abstract
4-6
page 2, lines 5-17
page 6, lines 30-33
page 8, lines 26-32
(3)
Y
CHAN DICK C ET AL, "Plasma Proprotein Convertase Subtilisin Kexin Type 9 as a Predictor of Carotid Atherosclerosis in Asymptomatic Adults", HEART, LUNG AND CIRCULATION, ELSEVIER, AMSTERDAM, NL,Vol. 25, No. 5, 18 November 2015 (2015-11-18), page 520-525,
XP029485015
1-3,7-10
cited in the application
A
abstract
4-6
page 521, column 1, paragraph 2
page 521, column 2, paragraph 2 - page 523, column 2, paragraph 1
(4)
A
MARIANNE BENN ET AL, "Low LDL Cholesterol by PCSK9 Variation Reduces Cardiovascular Mortality", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,Vol. 73, No. 24, 01 June 2019 (2019-06-01), page 3102-3114,
XP055677736
4-6
abstract
figure 1
(5)
A
JUNLAN CHUAN ET AL, "The association of the PCSK9 rs562556 polymorphism with serum lipids level: a meta-analysis", LIPIDS IN HEALTH AND DISEASE,Vol. 18, No. 1, 30 April 2019 (2019-04-30),
XP055677597
4-6
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014197752 A1
11 December 2014
AU 2014274844 A1
AU 2020201191 A1
CA 2914721 A1
CN 105705521 A
EA 201592267 A1
EP 3004171 A1
HK 1222865 A1
JP 2016523847 A
KR 20160024906 A
TW 201534324 A
TW 202021614 A
US 2016115246 A1
US 2018244801 A1
US 2020071422 A1
WO 2014197752 A1
21 January 2016
05 March 2020
11 December 2014
22 June 2016
29 April 2016
13 April 2016
14 July 2017
12 August 2016
07 March 2016
16 September 2015
16 June 2020
28 April 2016
30 August 2018
05 March 2020
11 December 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
11 November 2020
Date of mailing of the international search report:
20 November 2020
Authorized officer:
Thumb, Werner
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