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1. WO2018122837 - METHOD AND SYSTEM FOR RADIOFREQUENCY (RF) TISSUE(S) MONITORING

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

WHAT IS CLAIMED IS:

1. A system for estimation at least one dielectric property of tissue of a patient, comprising:

at least one internal probe for at least one of transmitting and receiving an RF signal, the internal probe set to be mounted on an elongated guiding element set for insertion via the pharynx into a tract of a patient, the internal probe and elongated guiding element are configured to be directly inserted into the tract independently of another guiding device;

at least one external probe which is set to be positioned in a location outside the body for at least one of transmitting and receiving an RF signal;

a processing unit configured to analyze an RF signal transmitted between at least one transducer of the at least one internal probe and at least one transducer of the at least one external probe, propagating via at least one tissue of the patient between walls of the tract and a skin layer of the patient, to estimate at least one dielectric property of the at least one tissue;

wherein the RF signals are unsuitable for generating anatomical images of the at least one tissues.

2. The system of claim 1, comprising an output unit configured to output the at least one dielectric property.

3. The system of claim 2, wherein the output unit is configured to output the at least one dielectric property in a spatial pattern corresponding to an anatomical arrangement of the at least one tissue, the spatial pattern being unsuitable for generating an anatomical image of the at least one tissue.

4. The system of claim 1, wherein the tract includes the trachea or esophagus.

5. The system of claim 1 or claim 2, wherein the at least one internal probe includes insulation material configured to protect the internal probe again damage from body fluids within the tract.

6. The system of any one of claims 1-5, wherein the elongated guiding element is a solid rod configured for navigation within the pharynx and the tract.

7. The system of any one of claim 1-6, wherein the elongated guiding element including the internal probe has a diameter small enough for insertion into the tract when the tract contains a pre-existing other tube.

8. The system of any one of claims 1-6, wherein the processing unit analyses the RF signal to estimate at least one of a fluid content level and a change in the fluid level of the at least one tissue.

9. The system of any one of claims 1-8, wherein the processing unit analyses the RF signal to estimate at least one of an air content level and a change in the air level of the at least one tissue.

10. The system of any one of claims 1-9, wherein the processing unit analyses the RF signal to estimate migrational movement of the at least one internal probe within the patient tract denoting migrational movement of at least one of an endotracheal tube within the trachea and a nasogastric tube within the stomach.

11. The system of any one of claims 1-10, wherein the processing unit analyses the RF signal to detect excess stomach acid in the esophagus.

12. The system of any one of claims 1-11, further comprising a ventilation analysis unit for electrical communication with the processing unit and with a ventilation machine programmed to ventilate the patient according to patient ventilation patterns, the ventilation machine generates signals indicative of the patient ventilation patterns, the processing unit correlates the RF signal denoting sensed ventilation patterns with the received patient ventilation patterns, to compare actual ventilation patterns in the patient tissue with desired ventilation patterns programmed for delivery by the ventilation machine.

13. The system of any one of claims 1-12, further comprising a mechanical ventilation machine interface for electrical coupling to a mechanical ventilation machine ventilating the patient, the processing unit performing a calibration of RF signals denoting sensed ventilation patterns based on patient ventilation parameters received from the mechanical ventilation machine, the processing unit analyzing the calibrated RF signals for changes in patient ventilation patterns.

14. The system of any one of claims 1-13, wherein the at least one internal probe includes an antenna and the at least one external probe includes an antenna.

15. The system of claim 14, wherein one or both antennas are a dipole antenna.

16. The system of any one of claims 1-15, wherein the RF signal has a frequency between about 300 Megahertz (MHz) and about 10 Gigahertz (GHz).

17. The system of any one of claims 1-16, wherein the frequency of the RF signal is selected to improve spatial resolution under higher attenuation during propagation from the internal probe positioned in the tract, through the at least one tissue, to the at least one external probe.

18. The system of any one of claims 1-17, wherein the processing unit analyses the RF signal to assess lung ventilation through the at least one tissue.

19. The system of claim 18, wherein lung ventilation is assessed for one or both of symmetrical ventilation between the left and right lung, and for adequate ventilation to at least one lung lobe.

20. The system of claim 18, wherein lung ventilation is individually assessed for different lung lobes based on RF signals traveling through each respective lung lobe.

21. The system of claim 18, wherein the processing unit generates a signal for adjusting a mechanical ventilation machine ventilating the patient based on the assessed lung ventilation, the generated signal transmitted to at least one of a monitor for display to a user and a ventilation controller of the mechanical ventilation machine for automatically adjusting the mechanical ventilation machine.

22. The system of any one of claims 1-21, wherein the processing unit analyses the RF signal to detect and/or monitor the abnormal presence of air in undesired body locations.

23. The system of any one of claims 1-22, wherein the processing unit registers the at least one parameter calculated from respective external probes to 2D or 3D images of the at least one tissue during a respiration cycle.

24. A method for estimating at least one biological parameter of tissue of a patient, comprising:

positioning at least one internal probe configured for at least one of transmitting and receiving an RF signal, via the pharynx into a tract of a patient, the at least one internal probe set for insertion and retraction from the tract using an elongated guiding element, the internal probe and elongated guiding element are configured to be directly inserted into the tract independently of another guiding device;

positioning at least one external probe outside the body of the patient in proximity to a skin layer of the patient, the external probe configured for at least one of transmitting and receiving an RF signal;

propagating the RF signal via at least one tissue between at least one transducer of the at least one internal probe and at least one transducer of the at least one external probe, the RF signal propagating via at least one tissue of the patient between walls of the tract and the skin layer of the patient;

analyzing the propagated RF signal to estimate at least one biological parameter of the at least one tissue; and

outputting the at least one biological parameter;

wherein the RF signals are unsuitable for generating anatomical images of the at least one tissues.

25. The method of claim 24, wherein the internal probe is positioned within an esophagus of an intubated patient having an endotracheal tube in the trachea, or wherein the internal probe is positioned within the trachea of a patient having a nasogastric tube positioned within the esophagus.

26. The method of claim 24, wherein the internal probe is positioned within an esophagus of a patient having a nasogastric tube positioned within the esophagus, or wherein the internal probe is positioned within the trachea of an intubated patient having an endotracheal tube in the trachea, the internal probe being positioned next to the nasogastric tube or the trachea.

27. The method of claim 24, wherein the at least one biological parameter comprises at least one ventilation parameter of the at least one tissue, the method further comprising adjusting a ventilation machine based on the at least one measured ventilation parameter, to reduce or prevent ventilation induced lung injury.

28. The method of claim 24 or claim 27, further comprising detecting migrational movement of at least one of an endotracheal tube and a nasogastric tube within the tract, the migration movement detected based on analysis of the RF signal transmitted and/or received by the at least one internal probe coupled to the endotracheal tube or the nasogastric tube.

29. The method of claim 28, further comprising re-adjusting the position of the endotracheal tube to improve patient ventilation.

30. The method of any one of claims 24-29, wherein the RF signal is transmitted by the at least one internal probe and received by the at least one external probe.

31. The method of any one of claims 24-30, wherein the tract is an esophagus or a trachea.

32. The method of any one of claims 24-31, wherein the patient is intubated and mechanically ventilated.

33. The method of any one of claims 24-32, further comprising removing the at least one internal probe from the tract after a measuring session has been completed.

34. The method of any one of claims 24-33, wherein the at least one tissue includes lung tissue.

35. The method of any one of claims 24-34, wherein the patient is a baby less than 12 months old.

36. The method of claim 35, wherein the baby is a prematurely born baby.

37. The method of any one of claims 24-36, further comprising calibrating propagation of RF signals between a plurality of the at least one external probe via the at least one tissue with analyzed RF signals between the at least one internal probe and the at least one external probe.

38. The method of claim 37, further monitoring the at least one biological parameter based only on the propagation of RF signals between the plurality of the at least one external probe.

39. The method of any one of claims 24-38, wherein the at least one internal probe and the at least one external probe are positioned to confine an individual lobe of a lung.

40. The method of any one of claims 24-39, further comprising detecting abnormal levels of at least one of air and water in the at least one tissue.

41. The method of claim 40, further comprising treating a patient medical condition to correct the abnormal level.

42. A method for monitoring a mechanically ventilated patient, comprising:

positioning at least one internal probe within a tract of a patient via the pharynx, using an elongated guiding element, the internal probe configured for at least one of transmitting and receiving an RF signal, the internal probe and elongated guiding element are configured to be directly inserted into the tract independently of another guiding device;

positioning at least one external probe in proximity to a skin layer of the patient, the external probe configured for at least one of transmitting and receiving an RF signal;

receiving applied ventilation pattern signals from a ventilation analysis unit coupled to a mechanical ventilation machine mechanically ventilating the patient;

correlating between the applied ventilation pattern signals and an RF signal propagated via at least one tissue between at least one transducer of the at least one internal probe and at least one transducer of the at least one external probe;

analyzing the correlated signal for monitoring at least one ventilation parameter of the patient; and

outputting the at least one ventilation parameter.

43. The method of claim 42, further comprising adjusting the mechanical ventilation machine ventilating the patient based on the correlated signal.

44. A system for estimating at least one ventilation parameter of a mechanically ventilated patient, comprising:

at least one internal probe set for insertion into a tract of a patient via the pharynx, the at least one internal probe set to be mounted on a elongated guiding element, the internal probe configured for at least one of transmitting and receiving an RF signal, the internal probe and elongated guiding element are configured to be directly inserted into the tract independently of another guiding device;

at least one external probe which is set to be mounted in an external location for receiving a propagated RF signal, the external probe configured for at least one of transmitting and receiving an RF signal;

a ventilation analysis unit for receiving applied ventilation pattern signals of a mechanical ventilation machine mechanically ventilating the patient;

a processing unit which analyzes a correlation between the applied ventilation pattern signals and an RF signal propagated via at least one tissue between at least one transducer of the at least one internal probe and at least one transducer of the at least one external probe, for monitoring at least one ventilation parameter of the patient; and

an output unit which outputs the at least one ventilation parameter.

45. The system of claim 44, wherein the processing unit performs a calibration of the propagated RF signals based on the applied ventilation pattern signals, the processing unit analyzing subsequent calibrated RF signals for changes in patient ventilation patterns.

46. The system of claim 44 or claim 45, wherein the processing unit generates a signal for adjusting the mechanical ventilation machine ventilating the patient based on assessed lung ventilation denoted by the at least one ventilation parameter, the generated signal transmitted to at least one of a monitor for display to a user and a ventilation controller of the mechanical ventilation machine for automatically adjusting the mechanical ventilation machine.

47. A system for estimation at least one dielectric property of tissue of a patient, comprising:

at least one intrabody probe set to be mounted on an elongated guiding element set for reversible cutting free insertion into a lumen of a patient continuous with the pharynx;

at least one extrabody probe which is set to be positioned in an extrabody location for receiving a propagated EM signal; and

a processing unit configured to analyze an EM signal transmitted between at least one transducer of the at least one intrabody probe and at least one transducer of the at least one extrabody probe, propagating via at least one tissue of the patient between walls of the lumen and a skin layer of the patient, to estimate at least one dielectric property of the at least one tissue.