Processing

Please wait...

Settings

Settings

Goto Application

1. WO2018129332 - EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES (TILS) WITH TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY (TNFRSF) AGONISTS AND THERAPEUTIC COMBINATIONS OF TILS AND TNFRSF AGONISTS


Disclaimer The image version (PDF) available on PATENTSCOPE is the official version. This online html version is provided to assist users. Despite the great care taken in its compilation to ensure a precise and accurate representation of the data appearing on the printed document/images, errors and/or omissions cannot be excluded due to the data transmittal, conversion and inherent limitations of the (optional) machine translation processes used. Hyperlinks followed by this symbol , are to external resources that are not controlled by WIPO. WIPO disclaims all liability regarding the above points.

INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/US2018/012605 116983-5008-WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
05 January 2018 06 January 2017
Applicant
IOVANCE BIOTHERAPEUTICS, INC
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 5/0783 (2010.01)i; C12N 5/078 (2010.01)i; A61K 35/17 (2015.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     C12N; A61K
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, WPI Data, BIOSIS, Sequence Search

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2015157636 A1 (H LEE MOFFITT CANCER CT & RES [US]; UNIV TEXAS [US]) 15 October 2015 (2015-10-15)
1,68,116,117,141
Y
page 2 - page 3
1-158
page 28 - page 30; examples 1-2
(2)
X
JESSICA ANN CHACON ET AL, "Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy", PLOS ONE,Vol. 8, No. 4, 01 April 2013 (2013-04-01), page e60031,
XP055416340
116,117,141,142
Y
page 2 - page 4; figures 1, 5-6
1-158
(3)
X
MACLEAN HALL ET AL, "Expansion of tumor-infiltrating lymphocytes (TIL) from human pancreatic tumors", JOURNAL FOR IMMUNOTHERAPY OF CANCER, BIOMED CENTRAL LTD, LONDON, UK,Vol. 4, No. 1, 18 October 2016 (2016-10-18), page 1-12,
XP021241432
1,68,116,117,141
Y
page 9; figure 3
1-158
(4)
X
J. A. CHACON ET AL, "Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy", CLINICAL CANCER RESEARCH,Vol. 21, No. 3, 01 February 2015 (2015-02-01), page 611-621,
XP055193636
1,68,116,117,141
Y
page 613 - page 615; figures 1-2
1-158
(5)
X
JESSICA ANN CHACON ET AL, "Continuous 4-1BB co-stimulatory signals for the optimal expansion of tumor-infiltrating lymphocytes for adoptive T-cell therapy", ONCOIMMUNOLOGY,Vol. 2, No. 9, 27 September 2013 (2013-09-27), page e25581,
XP055459714
116,117,141,142
page 25582; figure 1
(6)
Y
US 2016347846 A1 (TYKOCINSKI MARK L [US]) 01 December 2016 (2016-12-01)
1-158
paragraph [0208]
paragraph [0016]
(7)
A
US 2014212446 A1 (RILEY JAMES L [US] ET AL) 31 July 2014 (2014-07-31)
1-158
paragraph [0041]
paragraph [0042]
paragraph [0012]
(8)
A
A. SONG ET AL, "OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen", THE JOURNAL OF IMMUNOLOGY,Vol. 175, No. 6, 15 September 2005 (2005-09-15), page 3534-3541,
XP055459831
1-158
page 3534 - page 3535
(9)
A
JESSICA ANN CHACON ET AL, "Triggering co-stimulation directly in melanoma tumor fragments drives CD8 + tumor-infiltrating lymphocyte expansion with improved effector-memory properties", ONCOIMMUNOLOGY,Vol. 4, No. 12, 01 July 2015 (2015-07-01), page e1040219,
XP055459996
1-158
the whole document
(10)
A
VENKY RAMAKRISHNA ET AL, "Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab", JOURNAL FOR IMMUNOTHERAPY OF CANCER,Vol. 3, No. 1, 18 August 2015 (2015-08-18),
XP055414303
1-158
page 1 - page 3
(11)
A
ALEXANDER PEDROZA-GONZALEZ ET AL, "GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo", ONCOIMMUNOLOGY,Vol. 4, No. 12, 02 December 2015 (2015-12-02), page e1051297,
XP055449750
1-158
the whole document
(12)
A
US 2012244133 A1 (ROSENBERG STEVEN A [US] ET AL) 27 September 2012 (2012-09-27)
1-158
cited in the application
claims 1-2
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2015157636 A1
15 October 2015
EP 3154350 A1
US 2017044496 A1
WO 2015157636 A1
19 April 2017
16 February 2017
15 October 2015
US 2016347846 A1
01 December 2016
EP 2951199 A1
US 2016347846 A1
US 2018079821 A1
09 December 2015
01 December 2016
22 March 2018
US 2014212446 A1
31 July 2014
AU 2005250408 A1
CA 2568344 A1
EP 1765988 A2
EP 2295588 A1
ES 2653570 T3
JP 5070045 B2
JP 2008500052 A
US 2006034810 A1
US 2011262467 A1
US 2014212446 A1
US 2017319684 A1
WO 2005118788 A2
15 December 2005
15 December 2005
28 March 2007
16 March 2011
07 February 2018
07 November 2012
10 January 2008
16 February 2006
27 October 2011
31 July 2014
09 November 2017
15 December 2005
US 2012244133 A1
27 September 2012
US 2012244133 A1
US 2017152478 A1
WO 2012129201 A1
27 September 2012
01 June 2017
27 September 2012
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
19 March 2018
Date of mailing of the international search report:
09 April 2018
Authorized officer:
Paresce, Donata
Top    Part 1: 1 2 3 4 5 6         Part 2: A B C D E