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Machine translation
1. (US20170240698) Biodegradable Stealth Polymeric Particles Fabricated Using The Macromonomer Approach By Free Radical Dispersion Polymerization

Application Number: 15590239 Application Date: 09.05.2017
Publication Number: 20170240698 Publication Date: 24.08.2017
Publication Kind : A1
IPC:
C08G 63/78
A61K 9/16
C08G 63/06
A61K 31/7034
B01J 13/06
B01J 13/16
C08G 63/82
A61K 31/337
Applicants: Emmanuel Oyekanmi Akala
Howard University
Simeon Kolawole Adesina
Inventors: Emmanuel Oyekanmi Akala
Simeon Kolawole Adesina
Priority Data:
Title: (EN) Biodegradable Stealth Polymeric Particles Fabricated Using The Macromonomer Approach By Free Radical Dispersion Polymerization
Abstract:
(EN)

The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprising structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.