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1. WO2022108120 - MODIFIED HTERT PROMOTER FOR REGULATING CANCER CELL-SPECIFIC GENE EXPRESSION AND ANTI-TUMOR ADENOVIRUS CONTAINING SAME

Publication Number WO/2022/108120
Publication Date 27.05.2022
International Application No. PCT/KR2021/014180
International Filing Date 14.10.2021
IPC
C12N 15/86 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C12N 7/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
A61K 35/76 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • (주)큐리진 CURIGIN CO.,LTD. [KR]/[KR]
Inventors
  • 박성훈 PARK, Seong Hoon
  • 유중기 YOO, Jung Ki
  • 엄기환 UM, Ki Hwan
Agents
  • 위병갑 WIE, Byoung-Gap
Priority Data
10-2020-015550519.11.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) MODIFIED HTERT PROMOTER FOR REGULATING CANCER CELL-SPECIFIC GENE EXPRESSION AND ANTI-TUMOR ADENOVIRUS CONTAINING SAME
(FR) PROMOTEUR HTERT MODIFIÉ POUR RÉGULER L'EXPRESSION GÉNIQUE D'UNE CELLULE CANCÉREUSE SPÉCIFIQUE ET ADÉNOVIRUS ANTITUMORAL LE CONTENANT
(KO) 암세포 특이적 유전자 발현을 조절하는 변형된 HTERT 프로모터 및 이를 포함하는 항종양 아데노바이러스
Abstract
(EN) The present invention relates to a modified hTERT promoter for regulating cancer cell-specific gene expression and an oncolytic adenovirus comprising same. The modified hTERT promoter of the present invention increases the cancer-specific transcriptional activity of a target gene compared to the case where a wild-type hTERT promoter is used, and when the modified hTERT promoter is used for an oncolytic adenovirus, the tumor-killing effect is excellent compared to the case where an adenovirus is prepared using the wild-type hTERT promoter.
(FR) La présente invention concerne un promoteur hTERT modifié pour réguler l'expression génique d'une cellule cancéreuse spécifique et un adénovirus oncolytique le comprenant. Le promoteur hTERT modifié de la présente invention augmente l'activité transcriptionnelle spécifique du cancer d'un gène cible par comparaison avec le cas où un promoteur hTERT de type sauvage est utilisé et, lorsque le promoteur hTERT modifié est utilisé pour un adénovirus oncolytique, l'effet d'élimination de tumeur est excellent par rapport au cas où un adénovirus est préparé à l'aide du promoteur hTERT de type sauvage.
(KO) 본 발명은 암세포 특이적 유전자 발현을 조절하는 변형된 hTERT 프로모터 및 이를 포함하는 종양 살상용 아데노바이러스에 관한 것으로, 본 발명의 변형된 hTERT 프로모터는 야생형 hTERT 프로모터를 이용하는 경우와 비교하여 목적 유전자의 암 특이적인 전사 활성을 증가시키며, 상기 변형된 hTERT 프로모터를 종양 살상능 아데노바이러스에 이용하는 경우, 야생형 hTERT 프로모터를 이용하여 아데노바이러를 제조한 경우와 비교하여, 종양을 살상하는 효과가 우수하다.
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