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1. WO2022101916 - FUSOBACTERIUM BACTERIOPHAGE AND USES THEREOF

Publication Number WO/2022/101916
Publication Date 19.05.2022
International Application No. PCT/IL2021/051350
International Filing Date 11.11.2021
IPC
A61K 35/76 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
CPC
A61K 35/76
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants
  • BIOMX LTD. [IL]/[IL]
Inventors
  • ZELCBUCH, Lior Moshe
  • YAHAV, Sagit
  • KAHAN-HANUM, Maya
  • ZAK, Naomi Bluma
  • NINIO-MANY, Lihi
Agents
  • EHRLICH, Gal
  • WATERMAN, Hadassa
  • MELNICK, Geoffrey, L.
Priority Data
63/112,72912.11.2020US
63/183,69804.05.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FUSOBACTERIUM BACTERIOPHAGE AND USES THEREOF
(FR) BACTÉRIOPHAGE DE FUSOBACTERIUM ET SES UTILISATIONS
Abstract
(EN) A method of treating a disease associated with Fusobacterium nucleatum infection in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one isolated bacteriophage capable of infecting a Fusobacterium nucleatum bacterial species, wherein said at least one bacteriophage has a genomic nucleic acid sequence at least 85 % identical to the nucleic acid sequence as set forth in SEQ ID NOs: 1-7 or 15-20. Compositions for treating the disease are also disclosed.
(FR) La présente invention concerne un procédé pour traiter une maladie associée à une infection à Fusobacterium nucleatum chez un sujet en ayant besoin. Le procédé comprend l'administration au sujet d'une quantité thérapeutiquement efficace d'au moins un bactériophage isolé capable d'infecter une espèce bactérienne Fusobacterium nucleatum, ledit ou lesdits bactériophages ayant une séquence d'acide nucléique génomique au moins 85 % identique à la séquence d'acide nucléique présentée dans SEQ ID NO : 1-7 ou 15-20. L'invention concerne également des compositions pour traiter cette maladie.
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