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1. WO2022100746 - BISPECIFIC SINGLE-CHAIN ANTIBODY, ANTIBODY-LOADED RECOMBINANT ONCOLYTIC VIRUS, AND VIRUS COMBINATION

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Publication Number WO/2022/100746
Publication Date 19.05.2022
International Application No. PCT/CN2021/130773
International Filing Date 15.11.2021
IPC
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 7/01 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 35/763 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12R 1/93 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1Microorganisms
92Viruses
93Animal viruses
CPC
A61K 35/763
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/2809
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2809against the T-cell receptor (TcR)-CD3 complex
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
Applicants
  • 武汉滨会生物科技股份有限公司 BINHUI BIOPHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 刘滨磊 LIU, Binlei
  • 蔡林康 CAI, Linkang
  • 张思琪 ZHANG, Siqi
  • 胡翰 HU, Han
Agents
  • 武汉世跃专利代理事务所（普通合伙） SOON IP LAW FIRM
Priority Data
202011265931.613.11.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BISPECIFIC SINGLE-CHAIN ANTIBODY, ANTIBODY-LOADED RECOMBINANT ONCOLYTIC VIRUS, AND VIRUS COMBINATION
(FR) ANTICORPS BISPÉCIFIQUE À CHAÎNE UNIQUE, VIRUS ONCOLYTIQUE RECOMBINANT CHARGÉ D'ANTICORPS ET COMBINAISON DE VIRUS
(ZH) 双特异性单链抗体、负载抗体的重组溶瘤病毒及病毒组合
Abstract
(EN) The present invention provides a bispecific single-chain antibody BiTEs-PD-L1 capable of simultaneously binding to CD3 and PD-L1 on the surface of a tumor cell, an antibody-loaded recombinant oncolytic virus, and a virus combination. When BiTEs-PD-L1 enters a human body and binds to T cells, the T cells can be effectively activated, and the T cells are guided to kill tumor cells.
(FR) La présente invention concerne un anticorps bispécifique à chaîne unique BiTEs-PD-L1 pouvant se lier simultanément à CD3 et PD-L1 sur la surface d'une cellule tumorale, un virus oncolytique recombinant chargé d'anticorps, et une combinaison de virus. Lorsque BiTEs-PD-L1 entre dans un corps humain et se lie à des lymphocytes T, les lymphocytes T peuvent être activés de manière efficace, et les lymphocytes T sont guidés pour détruire des cellules tumorales.
(ZH) 本发明提供了一种能够同时结合CD3和肿瘤细胞表面PD-L1的双特异性单链抗体BiTEs-PD-L1、负载抗体的重组溶瘤病毒及病毒组合，当BiTEs-PD-L1进入体内与T细胞结合后，可以有效激活T细胞，并引导T细胞对肿瘤细胞进行杀伤。
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