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1. WO2013015152 - TECHNIQUE FOR CLEAVING OUT PART OF poly(A) CHAIN AND/OR 3'-TERMINAL SEQUENCE OF mRNA TO INHIBIT TRANSLATION REACTION

Publication Number WO/2013/015152
Publication Date 31.01.2013
International Application No. PCT/JP2012/068085
International Filing Date 17.07.2012
Chapter 2 Demand Filed 21.05.2013
IPC
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A01K 67/027 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 31/7105 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/713 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A01K 2207/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
05Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
A01K 2227/40
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
40Fish
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • 公立大学法人横浜市立大学 Public University Corporation Yokohama City University [JP]/[JP] (AllExceptUS)
  • 株式会社陽進堂 Yoshindo Inc. [JP]/[JP] (AllExceptUS)
  • 国立大学法人東京工業大学 Tokyo Institute of Technology [JP]/[JP] (AllExceptUS)
  • 和田 忠士 WADA, Tadashi [JP]/[JP] (UsOnly)
  • 竹田 圭 TAKEDA, Kei [JP]/[JP] (UsOnly)
  • 半田 宏 HANDA, Hiroshi [JP]/[JP] (UsOnly)
Inventors
  • 和田 忠士 WADA, Tadashi
  • 竹田 圭 TAKEDA, Kei
  • 半田 宏 HANDA, Hiroshi
Agents
  • 間山 世津子 MAYAMA, Setsuko
Priority Data
2011-16051222.07.2011JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) TECHNIQUE FOR CLEAVING OUT PART OF poly(A) CHAIN AND/OR 3'-TERMINAL SEQUENCE OF mRNA TO INHIBIT TRANSLATION REACTION
(FR) TECHNIQUE POUR LE CLIVAGE D'UNE PARTIE D'UNE CHAÎNE poly(A) ET/OU D'UNE SÉQUENCE 3'-TERMINALE D'UN ARNm POUR INHIBER UNE RÉACTION DE TRADUCTION
(JA) mRNAのpoly(A)鎖および/または3'末端配列の一部を切断し、翻訳反応を抑制する技術
Abstract
(EN)
Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAi method, a ribozyme method, an antisense method), and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene, which comprises cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA; a kit for inhibiting a translation reaction, which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA; a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene; and a non-human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.
(FR)
L'invention concerne un procédé artificiel d'inhibition de l'expression génique qui peut être conçu de façon plus facile en comparaison à des procédés classiques (un procédé ARNi, un procédé ribozyme, un procédé antisens), et dans lequel l'effet de celui-ci peut être facilement confirmé. L'invention concerne : un procédé d'inhibition de la réaction de traduction d'un gène cible qui comprend le clivage d'une partie d'une chaîne poly(A) et/ou d'une séquence 3'-terminale d'un ARNm cible; une trousse pour l'inhibition d'une réaction de traduction qui comprend un réactif capable de cliver une partie d'une chaîne poly(A) et/ou d'une séquence 3'-terminale d'un ARNm cible; une cellule dans laquelle un réactif capable de cliver une partie d'une chaîne poly(A) et/ou d'une séquence 3'-terminale d'un ARNm cible est introduit afin d'inhiber la réaction de traduction d'un gène cible; et un organisme vivant non humain dans lequel un réactif capable de cliver une partie d'une chaîne poly(A) et/ou d'une séquence 3'-terminale d'un ARNm cible est introduit afin d'inhiber la réaction de traduction d'un gène cible.
(JA)
 従来法(RNAi法・リボザイム法・アンチセンス法)よりも設計が簡便で、かつ効果の確認も容易な人為的遺伝子発現抑制方法を提供する。 標的mRNAのpoly(A)鎖および/または3'末端配列の一部を切断することを含む、標的遺伝子の翻訳反応を抑制する方法。標的mRNAのpoly(A)鎖および/または3'末端配列の一部を切断することができる試薬を含む、翻訳反応を抑制するためのキット;標的mRNAのpoly(A)鎖および/または3'末端配列の一部を切断することができる試薬が導入され、標的遺伝子の翻訳反応が抑制された細胞;及び標的mRNAのpoly(A)鎖および/または3'末端配列の一部を切断することができる試薬が導入され、標的遺伝子の翻訳反応が抑制された非ヒト生物も提供される。
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