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1. WO2020141444 - ANTIMICROBIAL DENTAL APPLIANCE

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

CLAIMS:

1. A dental appliance comprising:

a polymeric shell with an arrangement of one or more cavities configured to receive one or more teeth, wherein the polymeric shell comprises an antimicrobial lipid.

2. The dental appliance of claim 1, wherein the antimicrobial lipid comprises monolaurin.

3. The dental appliance of claim 1 or claim 2, wherein the antimicrobial lipid comprises an effective amount of monolaurin to reduce at least one of S. mutans, S. aureus, P. aeruginaosa, and combinations thereof, following 24-hour contact.

4. The dental appliance of any one of claims 1-3, wherein the antimicrobial lipid comprises between 1 weight percent (wt%) and 3 wt% monolaurin.

5. The dental appliance of any one of claim 1-4, wherein the polymeric shell comprises an outer layer with a first major external surface, an inner layer with a second major internal surface configured to contact the one or more teeth, and a core layer between the outer layer and the inner layer.

6. The dental appliance of claim 5, wherein the inner layer and the outer layer comprise the antimicrobial lipid, and wherein the core layer is substantially free of the antimicrobial lipid.

7. The dental appliance of any one of claims 1-6, wherein the antimicrobial lipid is a first antimicrobial lipid compound and wherein the polymeric shell comprises at least a second antimicrobial lipid compound.

8. The dental appliance of claim 7, wherein the second antimicrobial lipid compound comprises at least one of a metal, metal oxide, cationic surfactant free of aromatic groups, cationic antimicrobial polymer, antimicrobial lipid, alkyl carboxylic acid, an alkyl carboxylate ester carboxylic acid, and mixtures and combinations thereof, and wherein the cationic antimicrobial polymer is at least one of a polybiguanide and a polyquatemary amine.

9. The dental appliance of claim 7 or 8, wherein the second antimicrobial lipid compound is blended with the polymeric shell comprising the first antimicrobial lipid compound.

10. The dental appliance of any of the previous claims, wherein the polymeric shell comprises a polymer chosen from polyamide, polyethylene terephthalate, polybutylene terephthalate,

polyester/polycarbonate copolymer, polyolefin, cyclic olefin polymer, styrenic copolymer, polyetherimide, polyetheretherketone, polyethersulfone, polytrimethylene terephthalate, parylene and mixtures and combinations thereof.

11. The dental appliance of any of the previous claims, wherein the polymeric shell is configured to provide resistance to an impact from hydration by water for enhancing force persistence of the dental appliance.

12. The dental appliance of any of the previous claims, wherein after aging seven-days at 37 degrees Celsius (°C), a deflection of the dental appliance is substantially similar for either a wet dental appliance according to the Wet Deflection Test or a dry dental appliance according to the Dry Deflection

Test.

13. The dental appliance of any of the previous claims, wherein the polymeric shell with the antimicrobial lipid exhibits at least a 2-log microbial reduction following 24-hour contact against at least one of S. mutans, S. aureus, P. aeruginaosa, and combinations thereof.

14. The dental appliance of any of the previous claims, wherein the dental appliance transmits at least 90% of incident light with a wavelength of about 400 to about 750 nm.

15. A method comprising:

melt blending an antimicrobial lipid with a first extrudable material to form a stream;

extruding the stream to form a sheet; and

shaping the sheet to form an arrangement of one or more cavities configured to receive one or more teeth.

16. The method of claim 15, wherein extruding the stream to form the sheet comprises extruding the stream via a feed block to a die.

17. The method of claim 15 or 16, wherein the stream is a first stream and melt blending the antimicrobial lipid with the first extrudable material comprises blending with a first twin- screw extruder, further comprising melt blending a second extrudable material to form a second stream via a second twin-screw extruder.

18. The method of claim 17, wherein the first stream and the second stream are combined to form the sheet and the first stream is applied discontinuously in at least one of a down- stream direction, a cross-stream direction, and a combination thereof.

19. A method comprising:

forming a polymeric shell comprising a plurality of cavities in a first major surface thereof, wherein the polymeric shell comprises an antimicrobial lipid, and

wherein the cavities are configured to receive one or more teeth.

20. The method of claim 19, wherein forming the polymeric shell comprises extruding a polymeric material to form a sheet of polymeric material and the sheet of polymeric material is formed into the polymeric shell.

21. The method of claim 19, wherein the sheet of polymeric material is coated with a composition layer comprising the antimicrobial lipid prior to the sheet of polymeric material being formed into a polymeric shell.

22. The method of claim 19, further comprising, after forming the polymeric shell, applying a coating composition layer to the formed polymeric shell, wherein the coating composition layer comprises the antimicrobial lipid.

23. The method of any one of claim 19-22, wherein the antimicrobial lipid is monolaurin.