Processing

Please wait...

Settings

Settings

Goto Application

1. WO2002018446 - METHODS OF DESIGNING AND PRODUCING COMPOUNDS HAVING IMPROVED BINDING AFFINITY FOR CD154 OR OTHER TRIMERIC PROTEINS

Publication Number WO/2002/018446
Publication Date 07.03.2002
International Application No. PCT/US2001/027360
International Filing Date 31.08.2001
Chapter 2 Demand Filed 28.03.2002
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 14/70575
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
C07K 16/2875
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2875against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • BIOGEN, INC. [US]/[US] (AllExceptUS)
  • ZHENG, Zhongli [US]/[US] (UsOnly)
  • TAYLOR, Frederick, R. [US]/[US] (UsOnly)
  • BENJAMIN, Christopher, D. [US]/[US] (UsOnly)
  • HSU, Yen-Ming (UsOnly)
Inventors
  • ZHENG, Zhongli
  • TAYLOR, Frederick, R.
  • BENJAMIN, Christopher, D.
  • HSU, Yen-Ming
Agents
  • LIANG, Stanley, D.
Priority Data
60/230,24201.09.2000US
60/230,28001.09.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF DESIGNING AND PRODUCING COMPOUNDS HAVING IMPROVED BINDING AFFINITY FOR CD154 OR OTHER TRIMERIC PROTEINS
(FR) PROCEDES DE DESIGNATION ET DE PRODUCITON DE NOUVEAUX COMPOSES AYANT UNE MEILLEURE AFFINITE DE LIAISON POUR CD154 OU D'AUTRES PROTEINES TRIMERIQUES
Abstract
(EN) The present invention relates to methods for designing and producing novel CD40:CD154 binding interruptor compounds and methods using these compounds to treat conditions associated with inappropriate CD154 activation in a subject. This invention also relates to novel methods for screening candidate compounds for the properties of specifically binding CD154 and interrupting CD40:CD154 interaction. This invention further relates to methods of improving the binding affinity, or the ability to block CD40/CD154 interaction, of a synthetic molecule for a trimeric protein, such as CD154. These methods comprise converting a first synthetic molecule that cannot promote lattice or aggregate formation of its target trimeric protein to a second synthetic molecule that can promote lattice or aggregate formation of its target trimeric protein. This invention also relates to a two-dimensional lattice or aggregate comprising a plurality of trimeric CD154 on a cell surface or in solution, wherein the lattice or aggregate is formed by bivalent anti-CD154 antibodies associated with trimeric CD154 molecules.
(FR) La présente invention porte sur des procédés de désignation et de production de nouveaux composés interrupteurs de liaison CD40:CD154 et sur des procédés utilisant ces composés pour traiter des états associés à une activation inappropriée de CD154 chez un sujet. Cette invention porte également sur de nouveaux procédés de criblage de composés candidats des propriétés de liaison spécifique de CD154 et d'interruption de l'interaction de CD40:CD154. Cette invention porte en outre sur procédés visant à améliorer l'affinité de liaison, ou la capacité à bloquer l'interaction de CD40/CD154, d'une molécule synthétique d'une protéine trimérique telle que CD154. Ces procédés consistent à convertir une première molécule synthétique qui ne peut pas promouvoir la formation d'un réseau ou d'un agrégat de sa protéine trimérique cible sur une seconde molécule synthétique de sa protéine trimérique cible. Cette invention porte encore sur un réseau ou agrégat bidimensionnel comprenant une pluralité de protéines trimériques CD154 sur une surface cellulaire ou dans une solution, le réseau ou agrégat étant formé par des anticorps anti-CD154 bivalents associés aux molécules trimériques CD154.
Latest bibliographic data on file with the International Bureau