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6. (US20170008839) BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS

Application Number: 15114289 Application Date: 26.02.2015
Publication Number: 20170008839 Publication Date: 12.01.2017
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS2015017781 ; Publication Number: Click to see the data
IPC:
C07C 311/41
C07C 311/18
Applicants: HOWARD UNIVERSITY
Inventors: Xiang Simon WANG
Priority Data:
Title: (EN) BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS
Abstract:
(EN)

Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula:

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wherein, independent of each other,

    • each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl,
    • n is an integer of 0, 1, 2, or 3,
    • each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy,wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl,
    • m is an integer of 0, 1, 2, or 3, and
    • R represents di-valent hydrocarbyl, substituted or unsubstituted.