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Machine translation
1. (WO2014158811) NEWCASTLE DISEASE VIRUSES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/158811    International Application No.:    PCT/US2014/020299
Publication Date: 02.10.2014 International Filing Date: 04.03.2014
IPC:
A61K 39/17 (2006.01), A61P 35/00 (2006.01), C12N 15/09 (2006.01)
Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; One Gustave L. Levy Place New York, NY 10029 (US).
MEMORIAL SLOAN KETTERING CANCER CENTER [US/US]; 1275 York Avenue New York, NY 10065 (US)
Inventors: PALESE, Peter; (US).
GARCIA-SASTRE, Adolfo; (US).
ZAMARIN, Dmitriy; (US).
ALLISON, James; (US).
WOLCHOK, Jedd, D.; (US)
Agent: ANTLER, Adriane, M.; Jones Day 222 East 41st Street New York, NY 10017-6702 (US)
Priority Data:
61/782,994 14.03.2013 US
Title (EN) NEWCASTLE DISEASE VIRUSES AND USES THEREOF
(FR) VIRUS DE LA MALADIE DE NEWCASTLE ET LEURS UTILISATIONS
Abstract: front page image
(EN)Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.
(FR)L'invention concerne des virus chimériques de la maladie de Newcastle génétiquement modifiés pour exprimer un agoniste d'un signal de costimulation d'une cellule immunitaire et des compositions comprenant de tels virus. L'invention concerne également un virus chimérique de la maladie de Newcastle génétiquement modifié pour exprimer un antagoniste d'un signal inhibiteur d'une cellule immunitaire et des compositions comprenant de tels virus. Les virus chimériques de la maladie de Newcastle et les compositions sont utiles dans le traitement du cancer. De plus, l'invention concerne des méthodes de traitement du cancer comprenant l'administration de virus de la maladie de Newcastle en combinaison avec un agoniste d'un signal de costimulation d'une cellule immunitaire et/ou un antagoniste d'un signal inhibiteur d'une cellule immunitaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application