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An internet-of-things (IOT) robotic sterilization system that operates autonomously for use in the prevention of diseases, e.g., Coronavirus Disease 2019 (COVID-19), caused by pathogens such as coronavirus SARS-CoV-2 and other pathogens present within an interior space is described. A robotic sterilization device is communicatively coupled to the IOT base module via an IOT network, and includes a misting or fogging system fluidically coupled to a liquid reservoir, a sensor module including plurality of sensors, a controller, and a locomotion system. The robotic sterilization device navigates a path within the interior space while creating a disinfecting mist with the misting system, and may coordinate with other IOT-connected devices, such as the HVAC system, UV Vent sterilizers, scent dispensing appliances, and others to more efficaciously sanitize the interior space to protect humans by eliminating pathogens.