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5. (WO2017087835) COMPOSITION, METHOD OF MANUFACTURE, AND USE OF SITE-SPECIFIC DELIVERY OF BRUCEOLIDES FOR TREATMENT OF CANCER AND OTHER DISEASES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2017/087835    International Application No.:    PCT/US2016/062833
Publication Date: 26.05.2017 International Filing Date: 18.11.2016
IPC:
A61K 31/35 (2006.01), A61K 31/352 (2006.01), A61K 31/366 (2006.01), C07D 311/02 (2006.01), C07D 311/78 (2006.01), C07D 493/08 (2006.01)
Applicants: HOWARD UNIVERSITY [US/US]; (US)
Inventors: ADESINA, Simeon Kolawole; (US)
Agent: KRATZ, Rudy; (US).
HERRON, Joseph H.; (US).
PETERS, Nicholas; (US).
MITCHELL, Calista; (US)
Priority Data:
62/257,633 19.11.2015 US
62/350,439 15.06.2016 US
Title (EN) COMPOSITION, METHOD OF MANUFACTURE, AND USE OF SITE-SPECIFIC DELIVERY OF BRUCEOLIDES FOR TREATMENT OF CANCER AND OTHER DISEASES
(FR) COMPOSITION, PROCÉDÉ DE FABRICATION, ET UTILISATION D’ADMINISTRATION À UN SITE SPÉCIFIQUE DE BRUCÉOLIDES POUR LE TRAITEMENT DU CANCER ET D’AUTRES MALADIES
Abstract: front page image
(EN)Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.
(FR)La présente invention concerne des brucéolides pour le traitement du cancer, et d’autres maladies, ciblant sélectivement des cellules indésirables. Les brucéolides de l’invention peuvent comprendre un fragment clivable site-spécifique inhibant l’activité chimiotoxique jusqu’à ce qu’il soit clivé, c’est-à-dire, enlevé, dans et/ou à proximité d’un cancer devant être traité. De manière à faciliter l’administration sélective à des tumeurs cancéreuses, les brucéolides décrits peuvent être chargés dans, liés à, ou autrement portés par des nanoparticules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)