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5. (WO2013169361) IRON CHELATORS AS HIV-1 INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2013/169361    International Application No.:    PCT/US2013/031231
Publication Date: 14.11.2013 International Filing Date: 14.03.2013
IPC:
C07C 337/00 (2006.01), C07C 337/08 (2006.01), A61P 35/00 (2006.01)
Applicants: HOWARD UNIVERSITY [US/US]; 2400 Sixth Street N.W. Washington, DC 20059 (US)
Inventors: NEKHAI, Sergei; (US).
KOVALSKYY, Dmytro Borisovych; (US)
Agent: KRATZ, Rudy; Fitch, Even, Tabin & Flannery 120 S. Lasalle Street Suite 1600 Chicago, IL 60603 (US)
Priority Data:
61/644,842 09.05.2012 US
Title (EN) IRON CHELATORS AS HIV-1 INHIBITORS
(FR) CHÉLATEURS DU FER EN TANT QU'INHIBITEURS DU VIH-1
Abstract: front page image
(EN)The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/ or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.
(FR)La présente invention concerne des composés chélateurs destinés à chélater des ions métalliques. En particulier, la présente invention concerne des composés de (thio)semicarbazone et des composés de (thio)hydrazone, tels que PpYeT et PpYaT, qui sont des chélateurs d'ions métalliques, y compris les ions de fer. L'utilisation thérapeutique de tels composés et/ou de leurs complexes d'ions métalliques, comprend des procédés de traitement et d'inhibition de la réplication du VIH-1, en particulier dans des cellules infectées par le VIH-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)